{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:24:07Z","timestamp":1787426647293,"version":"build-2736575974"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202309000-00031\/figure1\/v\/2026-05-25T155815Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Human dental pulp stem cells (hDPSCs) promote recovery after ischemic stroke; however, the therapeutic efficacy is limited by the poor survival of transplanted cells. For\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    experiments in the present study, we used oxygen-glucose deprivation\/reoxygenation in hDPSCs to mimic cell damage induced by ischemia\/reperfusion. We found that miRNA-34a-5p (miR-34a) was elevated under oxygen-glucose deprivation\/reoxygenation conditions in hDPSCs. Inhibition of miR-34a facilitated the proliferation and antioxidant capacity and reduced the apoptosis of hDPSCs. Moreover, dual-luciferase reporter gene assay showed WNT1 and SIRT1 as the targets of miR-34a. In miR-34a knockdown cell lines, WNT1 suppression reduced cell proliferation, and SIRT1 suppression decreased the antioxidant capacity. Together, these results indicated that miR-34a regulates cell proliferation and antioxidant stress via targeting WNT1 and SIRT1, respectively. For\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    experiments, we injected genetically modified hDPSCs (anti34a-hDPSCs) into the brains of mice. We found that anti34a-hDPSCs significantly inhibited apoptosis, reduced cerebral edema and cerebral infarct volume, and improved motor function in mice. This study provides new insights into the molecular mechanism of the cell proliferation and antioxidant capacity of hDPSCs, and suggests a potential gene that can be targeted to improve the survival rate and efficacy of transplanted hDPSCs in brain after ischemic stroke.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.367831","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:25:33Z","timestamp":1676427933000},"page":"2029-2036","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke"],"prefix":"10.4103","volume":"18","author":[{"given":"Jianfeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pian","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-9247","authenticated-orcid":false,"given":"Qingsong","family":"Ye","sequence":"additional","affiliation":[{"name":"Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-8886","authenticated-orcid":false,"given":"Mingchang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"654654","DOI":"10.3389\/fcell.2021.654654","article-title":"Titanium nanotube modified with silver cross-linked basic fibroblast growth factor improves osteoblastic activities of dental pulp stem cells and antibacterial effect","volume":"9","author":"Albashari","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"R2-20260525","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"R3-20260525","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3727\/215517914X680038","article-title":"Immature dental pulp stem cells showed renotropic and pericyte-like properties in acute renal failure in rats","volume":"7","author":"Barros","year":"2015","journal-title":"Cell Med"},{"key":"R4-20260525","doi-asserted-by":"crossref","first-page":"165260","DOI":"10.1016\/j.bbadis.2018.09.012","article-title":"Current advances in ischemic stroke research and therapies","volume":"1866","author":"Barthels","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"R5-20260525","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cub.2007.06.068","article-title":"p53-mediated activation of miRNA34 candidate tumor-suppressor genes","volume":"17","author":"Bommer","year":"2007","journal-title":"Curr Biol"},{"key":"R6-20260525","doi-asserted-by":"crossref","first-page":"9328347","DOI":"10.1155\/2017\/9328347","article-title":"Mesenchymal stem cells improve healing of diabetic foot ulcer","volume":"2017","author":"Cao","year":"2017","journal-title":"J Diabetes Res"},{"key":"R7-20260525","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13148-016-0224-3","article-title":"Sirtuin functions and modulation:from chemistry to the clinic","volume":"8","author":"Carafa","year":"2016","journal-title":"Clin Epigenetics"},{"key":"R8-20260525","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"R9-20260525","doi-asserted-by":"crossref","first-page":"9391261","DOI":"10.1155\/2018\/9391261","article-title":"SIRT1 activity in peripheral blood mononuclear cells correlates with altered lung function in patients with chronic obstructive pulmonary disease","volume":"2018","author":"Conti","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"R10-20260525","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13287-020-01699-3","article-title":"Stem cell therapy:a potential approach for treatment of influenza virus and coronavirus-induced acute lung injury","volume":"11","author":"Du","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"R11-20260525","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.3389\/fimmu.2020.01746","article-title":"hUCMSCs mitigate LPS-induced trained immunity in ischemic stroke","volume":"11","author":"Feng","year":"2020","journal-title":"Front Immunol"},{"key":"R12-20260525","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1182\/blood-2008-02-139212","article-title":"Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma","volume":"112","author":"Gelebart","year":"2008","journal-title":"Blood"},{"key":"R13-20260525","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-0270(90)90154-8","article-title":"Beam-walking in rats:studies towards developing an animal model of functional recovery after brain injury","volume":"31","author":"Goldstein","year":"1990","journal-title":"J Neurosci Methods"},{"key":"R14-20260525","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.taap.2015.12.024","article-title":"Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1\/Nrf2-mediated inhibition of p38 MAPK pathway","volume":"292","author":"Gu","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"R15-20260525","doi-asserted-by":"crossref","first-page":"100931","DOI":"10.18632\/oncotarget.21753","article-title":"A molecular view of the radioresistance of gliomas","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"key":"R16-20260525","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1460-9568.2008.06599.x","article-title":"Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats:cell survival and functional recovery","volume":"29","author":"Hicks","year":"2009","journal-title":"Eur J Neurosci"},{"key":"R17-20260525","doi-asserted-by":"crossref","first-page":"831095","DOI":"10.1155\/2015\/831095","article-title":"Mesenchymal stem cells and cutaneous wound healing:current evidence and future potential","volume":"2015","author":"Isakson","year":"2015","journal-title":"Stem Cells Int"},{"key":"R18-20260525","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41467-017-02501-4","article-title":"Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task","volume":"9","author":"Itokazu","year":"2018","journal-title":"Nat Commun"},{"key":"R19-20260525","doi-asserted-by":"crossref","first-page":"1010428317701652","DOI":"10.1177\/1010428317701652","article-title":"MicroRNA-34 dysregulation in gastric cancer and gastric cancer stem cell","volume":"39","author":"Jafari","year":"2017","journal-title":"Tumour Biol"},{"key":"R20-20260525","doi-asserted-by":"crossref","first-page":"e02156","DOI":"10.1016\/j.heliyon.2019.e02156","article-title":"Selection of best reference genes for qRT-PCR analysis of human neural stem cells preconditioned with hypoxia or baicalein-enriched fraction extracted from Oroxylum indicum medicinal plant","volume":"5","author":"Kang","year":"2019","journal-title":"Heliyon"},{"key":"R21-20260525","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.3390\/cells9112385","article-title":"Secreted factors from stem cells of human exfoliated deciduous teeth directly activate endothelial cells to promote all processes of angiogenesis","volume":"9","author":"Kato","year":"2020","journal-title":"Cells"},{"key":"R22-20260525","first-page":"264","article-title":"The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8(+) T cells to tumors","volume":"11","author":"Kinosada","year":"2021","journal-title":"Am J Cancer Res"},{"key":"R23-20260525","doi-asserted-by":"crossref","first-page":"15507","DOI":"10.18632\/oncotarget.14662","article-title":"In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt\/\u03b2-catenin signaling pathway","volume":"8","author":"Kong","year":"2017","journal-title":"Oncotarget"},{"key":"R24-20260525","doi-asserted-by":"crossref","first-page":"e126268","DOI":"10.1172\/jci.insight.126268","article-title":"Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells","volume":"5","author":"Korshunova","year":"2020","journal-title":"JCI Insight"},{"key":"R25-20260525","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.canlet.2018.08.003","article-title":"Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts","volume":"435","author":"Koval","year":"2018","journal-title":"Cancer Lett"},{"key":"R26-20260525","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1167\/iovs.14-14383","article-title":"Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy","volume":"55","author":"Kowluru","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R27-20260525","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke:present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R28-20260525","doi-asserted-by":"crossref","first-page":"e13093","DOI":"10.1111\/cpr.13093","article-title":"Dental pulp stem cell-derived exosomes alleviate cerebral ischaemia-reperfusion injury through suppressing inflammatory response","volume":"54","author":"Li","year":"2021","journal-title":"Cell Prolif"},{"key":"R29-20260525","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13020-019-0244-y","article-title":"A tannin compound from Sanguisorba officinalis blocks Wnt\/\u03b2-catenin signaling pathway and induces apoptosis of colorectal cancer cells","volume":"14","author":"Li","year":"2019","journal-title":"Chin Med"},{"key":"R30-20260525","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/JIR.S249363","article-title":"Salvianolic acid B improves chronic mild stress-induced depressive behaviors in rats:involvement of AMPK\/SIRT1 signaling pathway","volume":"13","author":"Liao","year":"2020","journal-title":"J Inflamm Res"},{"key":"R31-20260525","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13287-019-1285-y","article-title":"miR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats","volume":"10","author":"Liu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"R32-20260525","first-page":"101","article-title":"MiRNA-155 promotes the invasion of colorectal cancer SW-480 cells through regulating the Wnt\/\u03b2-catenin","volume":"22","author":"Liu","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R33-20260525","doi-asserted-by":"crossref","first-page":"264","DOI":"10.12659\/MSM.904618","article-title":"Inhibition of mircoRNA-34a enhances survival of human bone marrow mesenchymal stromal\/stem cells under oxidative stress","volume":"24","author":"Liu","year":"2018","journal-title":"Med Sci Monit"},{"key":"R34-20260525","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/nm.4189","article-title":"Efficient derivation of microglia-like cells from human pluripotent stem cells","volume":"22","author":"Muffat","year":"2016","journal-title":"Nat Med"},{"key":"R35-20260525","first-page":"812547","article-title":"Odontogenic differentiation of human dental pulp stem cells stimulated by the calcium phosphate porous granules","volume":"2011","author":"Nam","year":"2011","journal-title":"J Tissue Eng"},{"key":"R36-20260525","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/stem.1104","article-title":"Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain","volume":"30","author":"Oki","year":"2012","journal-title":"Stem Cells"},{"key":"R37-20260525","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1172\/JCI58525","article-title":"Oxidative stress fuels Trypanosoma cruzi infection in mice","volume":"122","author":"Paiva","year":"2012","journal-title":"J Clin Invest"},{"key":"R38-20260525","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ymthe.2017.09.023","article-title":"Stem cell secretome and its effect on cellular mechanisms relevant to wound healing","volume":"26","author":"Park","year":"2018","journal-title":"Mol Ther"},{"key":"R39-20260525","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0:Updated guidelines for reporting animal research","volume":"18","author":"Percie","year":"2020","journal-title":"PLoS Biol"},{"key":"R40-20260525","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0963689718809090","article-title":"Stem cells from human exfoliated deciduous teeth (SHED) differentiate in vivo and promote facial nerve regeneration","volume":"28","author":"Pereira","year":"2019","journal-title":"Cell Transplant"},{"key":"R41-20260525","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13287-021-02339-0","article-title":"MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD (+)-Sirt1 pathway","volume":"12","author":"Pi","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"R42-20260525","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.4103\/1673-5374.303009","article-title":"The interaction of stem cells and vascularity in peripheral nerve regeneration","volume":"16","author":"Saffari","year":"2021","journal-title":"Neural Regen Res"},{"key":"R43-20260525","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.4103\/1673-5374.336870","article-title":"Role of adipose tissue grafting and adipose-derived stem cells in peripheral nerve surgery","volume":"17","author":"Saffari","year":"2022","journal-title":"Neural Regen Res"},{"key":"R44-20260525","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1093\/brain\/aws259","article-title":"Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice","volume":"135","author":"Sakata","year":"2012","journal-title":"Brain"},{"key":"R45-20260525","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/molbev\/msu129","article-title":"Inferring the evolutionary history of primate microRNA binding sites:overcoming motif counting biases","volume":"31","author":"Simkin","year":"2014","journal-title":"Mol Biol Evol"},{"key":"R46-20260525","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3727\/096368916X694391","article-title":"Human dental pulp stem cells are more effective than human bone marrow-derived mesenchymal stem cells in cerebral ischemic injury","volume":"26","author":"Song","year":"2017","journal-title":"Cell Transplant"},{"key":"R47-20260525","doi-asserted-by":"crossref","first-page":"990","DOI":"10.21037\/atm-20-5548","article-title":"Tetrandrine mediates renal function and redox homeostasis in a streptozotocin-induced diabetic nephropathy rat model through Nrf2\/HO-1 reactivation","volume":"8","author":"Su","year":"2020","journal-title":"Ann Transl Med"},{"key":"R48-20260525","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3727\/000000005783982594","article-title":"Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord","volume":"14","author":"Swanger","year":"2005","journal-title":"Cell Transplant"},{"key":"R49-20260525","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.3748\/wjg.v20.i36.13079","article-title":"Role of Nrf2 in chronic liver disease","volume":"20","author":"Tang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"R50-20260525","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCRESAHA.111.247916","article-title":"Developing microRNA therapeutics","volume":"110","author":"van","year":"2012","journal-title":"Circ Res"},{"key":"R51-20260525","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ccr.2011.03.010","article-title":"High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF\/\u03b2-catenin target gene, CDC25A","volume":"19","author":"Vijayakumar","year":"2011","journal-title":"Cancer Cell"},{"key":"R52-20260525","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/cr.2011.30","article-title":"A diterpenoid derivative 15-oxospiramilactone inhibits Wnt\/\u03b2-catenin signaling and colon cancer cell tumorigenesis","volume":"21","author":"Wang","year":"2011","journal-title":"Cell Res"},{"key":"R53-20260525","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s10529-017-2397-z","article-title":"miR-34a attenuates glioma cells progression and chemoresistance via targeting PD-L1","volume":"39","author":"Wang","year":"2017","journal-title":"Biotechnol Lett"},{"key":"R54-20260525","first-page":"5587","article-title":"MiR-638 inhibits cervical cancer metastasis through Wnt\/\u03b2-catenin signaling pathway and correlates with prognosis of cervical cancer patients","volume":"21","author":"Wei","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R55-20260525","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.4103\/1673-5374.306093","article-title":"Effects of primary microglia and astrocytes on neural stem cells in in vitro and in vivo models of ischemic stroke","volume":"16","author":"Wen","year":"2021","journal-title":"Neural Regen Res"},{"key":"R56-20260525","doi-asserted-by":"crossref","first-page":"8739730","DOI":"10.1155\/2019\/8739730","article-title":"Overexpression of BRCA1 in neural stem cells enhances cell survival and functional recovery after transplantation into experimental ischemic stroke","volume":"2019","author":"Xu","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"R57-20260525","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12943-020-01276-5","article-title":"Wnt signaling in breast cancer:biological mechanisms, challenges and opportunities","volume":"19","author":"Xu","year":"2020","journal-title":"Mol Cancer"},{"key":"R58-20260525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2016.04.045","article-title":"Nrf2\/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning","volume":"309","author":"Xue","year":"2016","journal-title":"Behav Brain Res"},{"key":"R59-20260525","doi-asserted-by":"crossref","first-page":"E10362","DOI":"10.1073\/pnas.1808575115","article-title":"mTORC1 signaling suppresses Wnt\/\u03b2-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level","volume":"115","author":"Zeng","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R60-20260525","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13287-015-0187-x","article-title":"Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells","volume":"6","author":"Zhang","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"R61-20260525","doi-asserted-by":"crossref","first-page":"e113972","DOI":"10.1371\/journal.pone.0113972","article-title":"Stroke increases neural stem cells and angiogenesis in the neurogenic niche of the adult mouse","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.367831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:31:00Z","timestamp":1786735860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.367831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.367831","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]},"assertion":[{"value":"2022-07-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}