{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:34:25Z","timestamp":1786739665682,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202310000-00030\/figure1\/v\/2026-05-25T160659Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Exosomes derived from human bone marrow mesenchymal stem cells (MSC-Exo) are characterized by easy expansion and storage, low risk of tumor formation, low immunogenicity, and anti-inflammatory effects. The therapeutic effects of MSC-Exo on ischemic stroke have been widely explored. However, the underlying mechanism remains unclear. In this study, we established a mouse model of ischemic brain injury induced by occlusion of the middle cerebral artery using the thread bolt method and injected MSC-Exo into the tail vein. We found that administration of MSC-Exo reduced the volume of cerebral infarction in the ischemic brain injury mouse model, increased the levels of interleukin-33 (IL-33) and suppression of tumorigenicity 2 receptor (ST2) in the penumbra of cerebral infarction, and improved neurological function.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    results showed that astrocyte-conditioned medium of cells deprived of both oxygen and glucose, to simulate ischemia conditions, combined with MSC-Exo increased the survival rate of primary cortical neurons. However, after transfection by IL-33 siRNA or ST2 siRNA, the survival rate of primary cortical neurons was markedly decreased. These results indicated that MSC-Exo inhibited neuronal death induced by oxygen and glucose deprivation through the IL-33\/ST2 signaling pathway in astrocytes. These findings suggest that MSC-Exo may reduce ischemia-induced brain injury through regulating the IL-33\/ST2 signaling pathway. Therefore, MSC-Exo may be a potential therapeutic method for ischemic stroke.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.369114","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:25:33Z","timestamp":1676427933000},"page":"2246-2251","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":39,"title":["Exosomes from bone marrow mesenchymal stem cells are a potential treatment for ischemic stroke"],"prefix":"10.4103","volume":"18","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Neurodegenerative Diseases and Department of Neurobiology, Jinzhou Medical University, Jinzhou, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Neurodegenerative Diseases and Department of Neurobiology, Jinzhou Medical University, Jinzhou, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Life Science, Jinzhou Medical University, Jinzhou, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong-Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jinzhou Medical University, Jinzhou, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7311-1260","authenticated-orcid":false,"given":"Jia","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Life Science, Jinzhou Medical University, Jinzhou, Liaoning Province, 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