{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:37:36Z","timestamp":1787870256231,"version":"build-2784847793"},"reference-count":76,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202310000-00038\/figure1\/v\/2026-05-25T160659Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Slit-Robo GTPase-activating protein 2 (SRGAP2) plays important roles in axon guidance, neuronal migration, synapse formation, and nerve regeneration. However, the role of SRGAP2 in neuroretinal degenerative disease remains unclear. In this study, we found that SRGAP2 protein was first expressed in the retina of normal mice at the embryonic stage and was mainly located in the mature retinal ganglion cell layer and the inner nuclear layer. SRGAP2 protein in the retina and optic nerve increased after optic nerve crush. Then, we established a heterozygous knockout (\n                    <jats:italic toggle=\"yes\">Srgap2<\/jats:italic>\n                    <jats:sup>+\/\u2013<\/jats:sup>\n                    ) mouse model of optic nerve crush and found that\n                    <jats:italic toggle=\"yes\">Srgap2<\/jats:italic>\n                    suppression increased retinal ganglion cell survival, lowered intraocular pressure, inhibited glial cell activation, and partially restored retinal function.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    experiments showed that\n                    <jats:italic toggle=\"yes\">Srgap2<\/jats:italic>\n                    suppression activated the mammalian target of rapamycin signaling pathway. RNA sequencing results showed that the expression of small heat shock protein genes (\n                    <jats:italic toggle=\"yes\">Cryaa<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Cryba4<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Crygs<\/jats:italic>\n                    ) related to optic nerve injury were upregulated in the retina of\n                    <jats:italic toggle=\"yes\">Srgap2<\/jats:italic>\n                    <jats:sup>+\/\u2013<\/jats:sup>\n                    mice. These results suggest that\n                    <jats:italic toggle=\"yes\">Srgap2<\/jats:italic>\n                    suppression reduced the robust activation of glial cells, activated the mammalian target of rapamycin signaling pathway related to nerve protein, increased the expression of small heat shock protein genes, inhibited the degeneration of retinal ganglion cells, and partially restored optic nerve function.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.369122","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:25:33Z","timestamp":1676427933000},"page":"2307-2314","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice"],"prefix":"10.4103","volume":"18","author":[{"given":"Yi-Jing","family":"Gan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"},{"name":"Department of Ophthalmology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Qin","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Xiao","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-567X","authenticated-orcid":false,"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry and Vision Science; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-6425","authenticated-orcid":false,"given":"Zai-Long","family":"Chi","sequence":"additional","affiliation":[{"name":"State 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