{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:13:59Z","timestamp":1793412839792,"version":"4.5.0"},"reference-count":238,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.4103\/1673-5374.371345","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T10:20:01Z","timestamp":1678530001000},"page":"2332-2342","source":"Crossref","is-referenced-by-count":38,"title":["\u03b1-Synuclein oligomers and fibrils: partners in crime in synucleinopathies"],"prefix":"10.4103","volume":"18","author":[{"given":"Alessandra","family":"Bigi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Cascella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"R1-20230518","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/jnc.14808","article-title":"\u03b1-synuclein oligomers and fibrils:a spectrum of species, a spectrum of toxicities","volume":"150","author":"Alam","year":"2019","journal-title":"J Neurochem"},{"key":"R2-20230518","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","article-title":"Chaperone-mediated autophagy markers in Parkinson disease brains","volume":"67","author":"Alvarez-Erviti","year":"2010","journal-title":"Arch Neurol"},{"key":"R3-20230518","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1242\/jcs.180737","article-title":"Ca2+is a key factor in \u03b1-synuclein-induced neurotoxicity","volume":"129","author":"Angelova","year":"2016","journal-title":"J Cell Sci"},{"key":"R4-20230518","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0006-8993(98)00734-3","article-title":"Immunoelectron-microscopic demonstration of NACP\/\u03b1-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies","volume":"808","author":"Arima","year":"1998","journal-title":"Brain Res"},{"key":"R5-20230518","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/brain\/awaa096","article-title":"Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates","volume":"143","author":"Arotcarena","year":"2020","journal-title":"Brain"},{"key":"R6-20230518","doi-asserted-by":"crossref","first-page":"e1901","DOI":"10.1038\/cddis.2015.283","article-title":"Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of \u03b1-synuclein aggregates","volume":"6","author":"Bae","year":"2015","journal-title":"Cell Death Dis"},{"key":"R7-20230518","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/nan.12260","article-title":"Unfolded protein response is activated in Lewy body dementias","volume":"42","author":"Baek","year":"2016","journal-title":"Neuropathol Appl Neurobiol"},{"key":"R8-20230518","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuron.2019.10.010","article-title":"Amyloid-beta (A\u03b2) plaques promote seeding and spreading of alpha-synuclein and tau in a mouse model of Lewy body disorders with A\u03b2pathology","volume":"105","author":"Bassil","year":"2020","journal-title":"Neuron"},{"key":"R9-20230518","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0074-7696(01)05004-5","article-title":"Endoplasmic reticulum of animal cells and its organization into structural and functional domains","volume":"205","author":"Baumann","year":"2001","journal-title":"Int Rev Cytol"},{"key":"R10-20230518","doi-asserted-by":"crossref","first-page":"111102","DOI":"10.1016\/j.celrep.2022.111102","article-title":"Rapid macropinocytic transfer of \u03b1-synuclein to lysosomes","volume":"40","author":"Bayati","year":"2022","journal-title":"Cell Rep"},{"key":"R11-20230518","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1471-4159.2010.07143.x","article-title":"Induction of the unfolded protein response by \u03b1-synuclein in experimental models of Parkinson's disease","volume":"116","author":"Bellucci","year":"2011","journal-title":"J Neurochem"},{"key":"R12-20230518","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00401-017-1755-1","article-title":"Alpha-synuclein oligomers:a new hope","volume":"134","author":"Bengoa-Vergniory","year":"2017","journal-title":"Acta Neuropathol"},{"key":"R13-20230518","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","article-title":"Neuronal calcium signaling","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"R14-20230518","doi-asserted-by":"crossref","first-page":"e44617","DOI":"10.15252\/embr.201744617","article-title":"Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation","volume":"19","author":"Betzer","year":"2018","journal-title":"EMBO Rep"},{"key":"R15-20230518","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3233\/JPD-130252","article-title":"Can intrabodies serve as neuroprotective therapies for Parkinson's disease?Beginning thoughts","volume":"3","author":"Bhatt","year":"2013","journal-title":"J Parkinsons Dis"},{"key":"R16-20230518","first-page":"431","article-title":"Exploring the release of toxic oligomers from \u03b1-synuclein fibrils with antibodies and STED microscopy","volume":"11","author":"Bigi","year":"2021","journal-title":"Life (Basel)"},{"key":"R17-20230518","doi-asserted-by":"crossref","first-page":"e2200086","DOI":"10.1002\/bies.202200086","article-title":"Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases","volume":"44","author":"Bigi","year":"2022","journal-title":"Bioessays"},{"key":"R18-20230518","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0022-510X(91)90311-T","article-title":"Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease","volume":"104","author":"Bindoff","year":"1991","journal-title":"J Neurol Sci"},{"key":"R19-20230518","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41531-022-00330-x","article-title":"Quantitative detection of \u03b1-synuclein and Tau oligomers and other aggregates by digital single particle counting","volume":"8","author":"Bl\u00f6meke","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"issue":"Suppl 3","key":"R20-20230518","doi-asserted-by":"crossref","first-page":"III\/1","DOI":"10.1007\/s00415-002-1301-4","article-title":"Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)","volume":"249","author":"Braak","year":"2002","journal-title":"J Neurol"},{"key":"R21-20230518","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003a","journal-title":"Neurobiol Aging"},{"key":"R22-20230518","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00702-002-0808-2","article-title":"Idiopathic Parkinson's disease:possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen","volume":"110","author":"Braak","year":"2003b","journal-title":"J Neural Transm"},{"key":"R23-20230518","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00401-016-1538-0","article-title":"Axonal transport and secretion of fibrillar forms of \u03b1-synuclein, A\u03b242 peptide and HTTExon 1","volume":"131","author":"Brahic","year":"2016","journal-title":"Acta Neuropathol"},{"key":"R24-20230518","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1172\/JCI85456","article-title":"Activation of tyrosine kinase c-Abl contributes to alpha-synuclein-induced neurodegeneration","volume":"126","author":"Brahmachari","year":"2016","journal-title":"J Clin Invest"},{"key":"R25-20230518","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3233\/JPD-171191","article-title":"c-Abl and Parkinson's disease:mechanisms and therapeutic potential","volume":"7","author":"Brahmachari","year":"2017","journal-title":"J Parkinsons Dis"},{"key":"R26-20230518","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling:function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"R27-20230518","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1111\/j.1742-4658.2007.05917.x","article-title":"Interactions between metals and a-synuclein\u2014Function or artefact?","volume":"274","author":"Brown","year":"2007","journal-title":"FEBS J"},{"key":"R28-20230518","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2017.10.003","article-title":"Therapeutic approaches to target alpha-synuclein pathology","volume":"298","author":"Brundin","year":"2017","journal-title":"Exp Neurol"},{"key":"R29-20230518","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/mds.27738","article-title":"Randomized phase I clinical trial of anti-\u03b1-synuclein antibody BIIB054","volume":"34","author":"Brys","year":"2019","journal-title":"Mov Disord"},{"key":"R30-20230518","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.1195227","article-title":"Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"key":"R31-20230518","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.1038\/nature12125","article-title":"Properties of native brain \u03b1-synuclein","volume":"498","author":"Burr\u00e9","year":"2013","journal-title":"Nature"},{"key":"R32-20230518","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JPD-150642","article-title":"The synaptic function of \u03b1-synuclein","volume":"5","author":"Burr\u00e9","year":"2015","journal-title":"J Parkinsons Dis"},{"key":"R33-20230518","doi-asserted-by":"crossref","first-page":"a024091","DOI":"10.1101\/cshperspect.a024091","article-title":"Cell biology and pathophysiology of \u03b1-synuclein","volume":"8","author":"Burr\u00e9","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R34-20230518","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1110\/ps.041255905","article-title":"Helix periodicity, topology, and dynamics of membrane-associated \u03b1-synuclein","volume":"14","author":"Bussell","year":"2005","journal-title":"Protein Sci"},{"key":"R35-20230518","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.7326\/M22-1438","article-title":"Oral ENT-01 targets enteric neurons to treat constipation in Parkinson disease:a randomized controlled trial","volume":"175","author":"Camilleri","year":"2022","journal-title":"Ann Intern Med"},{"key":"R36-20230518","first-page":"203","article-title":"The gut-brain axis:interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann Gastroenterol"},{"key":"R37-20230518","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1021\/acschembio.9b00312","article-title":"Probing the origin of the toxicity of oligomeric aggregates of \u03b1-synuclein with antibodies","volume":"14","author":"Cascella","year":"2019","journal-title":"ACS Chem Biol"},{"key":"R38-20230518","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1038\/s41467-021-21937-3","article-title":"The release of toxic oligomers from \u03b1-synuclein fibrils induces dysfunction in neuronal cells","volume":"12","author":"Cascella","year":"2021","journal-title":"Nat Commun"},{"key":"R39-20230518","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00018-022-04166-9","article-title":"Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies","volume":"79","author":"Cascella","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"R40-20230518","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1007\/s11064-012-0780-7","article-title":"Differential activation of the ER stress factor XBP1 by oligomeric assemblies","volume":"37","author":"Castillo-Carranza","year":"2012","journal-title":"Neurochem Res"},{"key":"R41-20230518","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/BJ20111924","article-title":"Toxic prefibrillar \u03b1-synuclein amyloid oligomers adopt a distinctive antiparallel \u03b2-sheet structure","volume":"443","author":"Celej","year":"2012","journal-title":"Biochem J"},{"key":"R42-20230518","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00726-009-0339-3","article-title":"Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra\/extracellular pathways","volume":"38","author":"Cenini","year":"2010","journal-title":"Amino Acids"},{"key":"R43-20230518","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","article-title":"Gut-seeded \u03b1-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice","volume":"23","author":"Challis","year":"2020","journal-title":"Nat Neurosci"},{"key":"R44-20230518","doi-asserted-by":"crossref","first-page":"15313","DOI":"10.1074\/jbc.M213128200","article-title":"A broken \u03b1-helix in folded \u03b1- Synuclein","volume":"278","author":"Chandra","year":"2003","journal-title":"J Biol Chem"},{"key":"R45-20230518","doi-asserted-by":"crossref","first-page":"e92295","DOI":"10.1172\/jci.insight.92295","article-title":"\u03b1-Synuclein in gut endocrine cells and its implications for Parkinson's disease","volume":"2","author":"Chandra","year":"2017","journal-title":"JCI Insight"},{"key":"R46-20230518","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1021\/acs.langmuir.6b02572","article-title":"\u03b1-Synuclein oligomers stabilize pre-existing defects in supported bilayers and propagate membrane damage in a fractal-like pattern","volume":"32","author":"Chaudhary","year":"2016","journal-title":"Langmuir"},{"key":"R47-20230518","doi-asserted-by":"crossref","first-page":"102997","DOI":"10.1016\/j.nicl.2022.102997","article-title":"Advanced brain aging in multiple system atrophy compared to Parkinson's disease","volume":"34","author":"Chen","year":"2022","journal-title":"Neuroimage Clin"},{"key":"R48-20230518","first-page":"E1994","article-title":"Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation","volume":"112","author":"Chen","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R49-20230518","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","article-title":"Protein misfolding, amyloid, formation and human disease:a summary of progress over the last decade","volume":"86","author":"Chiti","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"R50-20230518","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1073\/pnas.1218424110","article-title":"Large \u03b1-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking","volume":"110","author":"Choi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R51-20230518","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1523\/JNEUROSCI.5367-11.2012","article-title":"Endoplasmic reticulum stress is important for the manifestations of \u03b1-synucleinopathy in vivo","volume":"32","author":"Colla","year":"2012","journal-title":"J Neurosci"},{"key":"R52-20230518","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/jnnp.74.7.852","article-title":"Lewy body cortical involvement may not always predict dementia in Parkinson's disease","volume":"74","author":"Colosimo","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R53-20230518","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jmb.2011.06.026","article-title":"Structured regions of alpha-synuclein fibrils include the early-onset Parkinson's disease mutation sites","volume":"411","author":"Comellas","year":"2011","journal-title":"J Mol Biol"},{"key":"R54-20230518","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/3311","article-title":"Accelerated in vitro fibril formation by a mutant \u03b1-synuclein linked to early-onset Parkinson disease","volume":"4","author":"Conway","year":"1998","journal-title":"Nat Med"},{"key":"R55-20230518","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1126\/science.1129462","article-title":"Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models","volume":"313","author":"Cooper","year":"2006","journal-title":"Science"},{"key":"R56-20230518","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cell.2012.03.037","article-title":"Direct observation of the interconversion of normal and toxic forms of \u03b1-synuclein","volume":"149","author":"Cremades","year":"2012","journal-title":"Cell"},{"key":"R57-20230518","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/bs.ircmb.2016.08.010","article-title":"Structural characteristics of \u03b1-synuclein oligomers","volume":"329","author":"Cremades","year":"2017","journal-title":"Int Rev Cell Mol Biol"},{"key":"R58-20230518","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0304-3940(00)01440-3","article-title":"Characterisation of isolated alphasynuclein filaments from substantia nigra of Parkinson's disease brain","volume":"292","author":"Crowther","year":"2000","journal-title":"Neurosci Lett"},{"key":"R59-20230518","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1126\/science.1101738","article-title":"Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy","volume":"305","author":"Cuervo","year":"2004","journal-title":"Science"},{"key":"R60-20230518","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1523\/JNEUROSCI.2617-07.2007","article-title":"Different species of alpha-synuclein oligomers induce calcium influx and seeding","volume":"27","author":"Danzer","year":"2007","journal-title":"J Neurosci"},{"key":"R61-20230518","doi-asserted-by":"crossref","first-page":"100910","DOI":"10.1016\/j.isci.2020.100910","article-title":"\u03b1-Synuclein translocates to the nucleus to activate retinoic-acid-dependent gene transcription","volume":"23","author":"Davidi","year":"2020","journal-title":"iScience"},{"key":"R62-20230518","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ymgme.2021.01.002","article-title":"Diagnosing neuronopathic Gaucher disease:new considerations and challenges in assigning Gaucher phenotypes","volume":"132","author":"Daykin","year":"2021","journal-title":"Mol Genet Metab"},{"key":"R63-20230518","doi-asserted-by":"crossref","first-page":"eabc4364","DOI":"10.1126\/sciadv.abc4364","article-title":"Novel self-replicating \u03b1-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons","volume":"6","author":"De Giorgi","year":"2020","journal-title":"Sci Adv"},{"key":"R64-20230518","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41531-020-00139-6","article-title":"Protection from \u03b1-synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20","volume":"6","author":"De Miranda","year":"2020","journal-title":"NPJ Parkinsons Dis"},{"key":"R65-20230518","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/nan.12298","article-title":"Review:sporadic Parkinson's disease:development and distribution of \u03b1-synuclein pathology","volume":"42","author":"Del Tredici","year":"2016","journal-title":"Neuropathol Appl Neurobiol"},{"key":"R66-20230518","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer's disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol Neurodegener"},{"key":"R67-20230518","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1074\/jbc.M710012200","article-title":"Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain","volume":"283","author":"Devi","year":"2008","journal-title":"J Biol Chem"},{"key":"R68-20230518","doi-asserted-by":"crossref","first-page":"342ra78","DOI":"10.1126\/scitranslmed.aaf3634","article-title":"\u03b1-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease","volume":"8","author":"Di Maio","year":"2016","journal-title":"Sci Transl Med"},{"key":"R69-20230518","doi-asserted-by":"crossref","first-page":"10209","DOI":"10.1021\/bi020139h","article-title":"Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes","volume":"41","author":"Ding","year":"2002","journal-title":"Biochemistry"},{"key":"R70-20230518","doi-asserted-by":"crossref","first-page":"11750","DOI":"10.1523\/JNEUROSCI.0234-12.2012","article-title":"Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation","volume":"32","author":"Di\u00f3genes","year":"2012","journal-title":"J Neurosci"},{"key":"R71-20230518","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.nbd.2011.10.026","article-title":"Olfaction in Parkinson's disease and related disorders","volume":"46","author":"Doty","year":"2012","journal-title":"Neurobiol Dis"},{"key":"R72-20230518","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1006\/jmbi.2001.4538","article-title":"Conformational properties of \u03b1- synuclein in its free and lipid-associated states","volume":"307","author":"Eliezer","year":"2001","journal-title":"J Mol Biol"},{"key":"R73-20230518","doi-asserted-by":"crossref","first-page":"32721","DOI":"10.1038\/srep32721","article-title":"Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases","volume":"6","author":"Evangelisti","year":"2016","journal-title":"Sci Rep"},{"key":"R74-20230518","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/nn.4648","article-title":"\u03b1-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B","volume":"20","author":"Ferreira","year":"2017","journal-title":"Nat Neurosci"},{"key":"R75-20230518","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1073\/pnas.0809232106","article-title":"Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence","volume":"106","author":"Ferreon","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R76-20230518","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41419-018-1154-0","article-title":"Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease","volume":"9","author":"Franco-Iborra","year":"2018","journal-title":"Cell Death Dis"},{"key":"R77-20230518","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.aan6160","article-title":"Structural basis of membrane disruption and cellular toxicity by \u03b1-synuclein oligomers","volume":"358","author":"Fusco","year":"2017","journal-title":"Science"},{"key":"R78-20230518","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1007\/s12035-018-0937-8","article-title":"Bidirectional neural interaction between central dopaminergic and gut lesions in Parkinson's disease models","volume":"55","author":"Garrido-Gil","year":"2018","journal-title":"Mol Neurobiol"},{"key":"R79-20230518","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12104-011-9324-3","article-title":"Solid-state NMR sequential assignments of \u03b1-synuclein","volume":"6","author":"Gath","year":"2012","journal-title":"Biomol NMR Assign"},{"key":"R80-20230518","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson's disease, 1990-2016:a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","year":"2018","journal-title":"Lancet Neurol"},{"key":"R81-20230518","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/hmg\/ddaa085","article-title":"Glucocerebrosidase deficiency promotes release of \u03b1-synuclein fibrils from cultured neurons","volume":"29","author":"Gegg","year":"2020","journal-title":"Hum Mol Genet"},{"key":"R82-20230518","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1038\/srep09228","article-title":"Structure based aggregation studies reveal the presence of helix-rich intermediate during \u03b1-Synuclein aggregation","volume":"5","author":"Ghosh","year":"2015","journal-title":"Sci Rep"},{"key":"R83-20230518","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1074\/jbc.M008919200","article-title":"A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly","volume":"276","author":"Giasson","year":"2001","journal-title":"J Biol Chem"},{"key":"R84-20230518","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.3233\/JPD-179005","article-title":"The synucleinopathies:twenty years on","volume":"7","author":"Goedert","year":"2017","journal-title":"J Parkinsons Dis"},{"key":"R85-20230518","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.2507-13.2014","article-title":"\u03b1-Synuclein is localized to mitochondria-associated ER membranes","volume":"34","author":"Guardia-Laguarta","year":"2014","journal-title":"J Neurosci"},{"key":"R86-20230518","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218043","article-title":"Multiplicity of \u03b1-synuclein aggregated species and their possible roles in disease","volume":"21","author":"Gracia","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R87-20230518","doi-asserted-by":"crossref","first-page":"e48907","DOI":"10.7554\/eLife.48907","article-title":"Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy","volume":"8","author":"Guerrero-Ferreira","year":"2019","journal-title":"Elife"},{"key":"R88-20230518","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.410370604","article-title":"Low platelet mitochondrial complex I and complex II\/III activity in early untreated Parkinson's disease","volume":"37","author":"Haas","year":"1995","journal-title":"Ann Neurol"},{"issue":"(Pt 12)","key":"R89-20230518","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1093\/brain\/awp293","article-title":"Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease","volume":"132","author":"Hattingen","year":"2009","journal-title":"Brain"},{"key":"R90-20230518","first-page":"2","article-title":"Targeting neurons in the gastrointestinal tract to treat Parkinson's disease","volume":"1","author":"Hauser","year":"2019","journal-title":"Clin Park Relat Disord"},{"key":"R91-20230518","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fgene.2017.00177","article-title":"Mitochondria:a common target for genetic mutations and environmental toxicants in Parkinson's disease","volume":"8","author":"Helley","year":"2017","journal-title":"Front Genet"},{"key":"R92-20230518","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physrev.00001.2011","article-title":"The unfolded protein response:integrating stress signals through the stress sensor IRE1\u03b1","volume":"91","author":"Hetz","year":"2011","journal-title":"Physiol Rev"},{"key":"R93-20230518","doi-asserted-by":"crossref","first-page":"134316","DOI":"10.1016\/j.neulet.2019.134316","article-title":"\u03b1-Synuclein pathology in Parkinson's disease and related \u03b1-synucleinopathies","volume":"709","author":"Henderson","year":"2019","journal-title":"Neurosci Lett"},{"key":"R94-20230518","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.neuron.2019.12.004","article-title":"Glucocerebrosidase activity modulates neuronal susceptibility to pathological \u03b1-synuclein Insult","volume":"105","author":"Henderson","year":"2020a","journal-title":"Neuron"},{"key":"R95-20230518","doi-asserted-by":"crossref","first-page":"104712","DOI":"10.1016\/j.nbd.2019.104712","article-title":"Characterization of novel conformation-selective \u03b1-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease","volume":"136","author":"Henderson","year":"2020b","journal-title":"Neurobiol Dis"},{"key":"R96-20230518","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbrc.2016.09.109","article-title":"Alpha-synuclein activates BV2 microglia dependent on its aggregation state","volume":"479","author":"Hoffmann","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"R97-20230518","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-014-1343-6","article-title":"Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats","volume":"28","author":"Holmqvist","year":"2014","journal-title":"Acta Neuropathol"},{"key":"R98-20230518","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10654-014-9885-4","article-title":"Patterns of cognitive function in aging:the Rotterdam Study","volume":"29","author":"Hoogendam","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"R99-20230518","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2007.01.043","article-title":"Activation of the unfolded protein response in Parkinson's disease","volume":"354","author":"Hoozemans","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"R100-20230518","doi-asserted-by":"crossref","first-page":"114402","DOI":"10.1016\/j.addr.2022.114402","article-title":"Lysosomal functions and dysfunctions:Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease","volume":"187","author":"Horowitz","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"R101-20230518","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/mds.27326","article-title":"Stool immune profiles evince gastrointestinal inflammation in Parkinson's disease","volume":"33","author":"Houser","year":"2018","journal-title":"Mov Disord"},{"key":"R102-20230518","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bbapap.2018.10.006","article-title":"Disruptive membrane interactions of alpha-synuclein aggregates","volume":"1867","author":"Iyer","year":"2019","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"R103-20230518","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuroscience.2011.10.016","article-title":"Determining nuclear localization of alpha-synuclein in mouse brains","volume":"199","author":"Huang","year":"2011","journal-title":"Neuroscience"},{"key":"R104-20230518","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ana.23746","article-title":"\u03b1-Synuclein oligomers and clinical implications for Parkinson disease","volume":"73","author":"Kalia","year":"2013","journal-title":"Ann Neurol"},{"key":"R105-20230518","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"R106-20230518","doi-asserted-by":"crossref","first-page":"13482","DOI":"10.1074\/jbc.M117.780296","article-title":"Selective imaging of internalized proteopathic \u03b1-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies","volume":"292","author":"Karpowicz","year":"2017","journal-title":"J Biol Chem"},{"key":"R107-20230518","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"R108-20230518","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fphar.2012.00061","article-title":"Physiology and pathology of calcium signaling in the brain","volume":"3","author":"Kawamoto","year":"2012","journal-title":"Front Pharmacol"},{"key":"R109-20230518","doi-asserted-by":"crossref","first-page":"30891","DOI":"10.1038\/srep30891","article-title":"Exposure to bacterial endotoxin generates a distinct strain of \u03b1-synuclein fibril","volume":"6","author":"Kim","year":"2016","journal-title":"Sci Rep"},{"key":"R110-20230518","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1073\/pnas.1700465115","article-title":"GBA1 deficiency negatively affects physiological \u03b1-synuclein tetramers and related multimers","volume":"115","author":"Kim","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R111-20230518","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12017-019-08539-5","article-title":"Chronic mild gut inflammation accelerates brain neuropathology and motor dysfunction in \u03b1-synuclein mutant mice","volume":"21","author":"Kishimoto","year":"2019","journal-title":"Neuromol Med"},{"key":"R112-20230518","doi-asserted-by":"crossref","first-page":"782082","DOI":"10.3389\/fnagi.2021.782082","article-title":"The gut-brain axis and its relation to Parkinson's disease:a review","volume":"13","author":"Klann","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"R113-20230518","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2014.01.010","article-title":"Targeting alpha synuclein with a microRNA-embedded silencing vector in the rat substantia nigra:positive and negative effects","volume":"1550","author":"Khodr","year":"2014","journal-title":"Brain Res"},{"key":"R114-20230518","doi-asserted-by":"crossref","first-page":"909273","DOI":"10.3389\/fnagi.2022.909273","article-title":"Impact of aging on animal models of Parkinson's disease","volume":"14","author":"Kl\u00e6strup","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"R115-20230518","doi-asserted-by":"crossref","first-page":"e64649","DOI":"10.1371\/journal.pone.0064649","article-title":"Altered serum IgG levels to \u03b1-synuclein in dementia with Lewy bodies and Alzheimer's disease","volume":"8","author":"Koehler","year":"2013","journal-title":"PLoS One"},{"key":"R116-20230518","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nm1747","article-title":"Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease","volume":"14","author":"Kordower","year":"2008","journal-title":"Nat Med"},{"key":"R117-20230518","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s13311-022-01288-7","article-title":"Alpha-synuclein immunization strategies for synucleinopathies in clinical studies:a biological perspective","volume":"19","author":"Knecht","year":"2022","journal-title":"Neurotherapeutics"},{"key":"R118-20230518","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41570-021-00254-9","article-title":"Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases","volume":"5","author":"Kulenkampff","year":"2021","journal-title":"Na Rev Chem"},{"key":"R119-20230518","doi-asserted-by":"crossref","first-page":"eabm6393","DOI":"10.1126\/sciadv.abm6393","article-title":"Mutant glucocerebrosidase impairs \u03b1-synuclein degradation by blockade of chaperone-mediated autophagy","volume":"8","author":"Kuo","year":"2022","journal-title":"Sci Adv"},{"key":"R120-20230518","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.chembiol.2018.08.005","article-title":"Potent \u03b1-synuclein aggregation inhibitors, identified by high-throughput screening, mainly target the monomeric state","volume":"25","author":"Kurnik","year":"2018","journal-title":"Cell Chem Biol"},{"key":"R121-20230518","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s13311-020-00853-2","article-title":"Immunotherapies for aging-related neurodegenerative diseases-emerging perspectives and new targets","volume":"17","author":"Kwon","year":"2020","journal-title":"Neurotherapeutics"},{"key":"R122-20230518","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1056\/NEJMoa2203395","article-title":"Trial of cinpanemab in early Parkinson's disease","volume":"387","author":"Lang","year":"2022","journal-title":"N Engl J Med"},{"key":"R123-20230518","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0022-2836(02)00735-0","article-title":"Alpha-synuclein, especially the Parkinson's disease-associated mutants, form pore-like annular and tubular protofibrils","volume":"322","author":"Lashuel","year":"2002","journal-title":"J Mol Biol"},{"key":"R124-20230518","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41467-018-03111-4","article-title":"C-terminal calcium binding of \u03b1-synuclein modulates synaptic vesicle interaction","volume":"9","author":"Lautenschl\u00e4ger","year":"2018","journal-title":"Nat Commun"},{"key":"R125-20230518","doi-asserted-by":"crossref","first-page":"e12728","DOI":"10.1371\/journal.pone.0012728","article-title":"Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms","volume":"5","author":"Lebouvier","year":"2010","journal-title":"PLoS One"},{"key":"R126-20230518","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.biocel.2008.01.017","article-title":"Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein","volume":"40","author":"Lee","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"R127-20230518","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.3390\/ijms22105392","article-title":"\u03b1-Synuclein A53T binds to transcriptional adapter 2-alpha and blocks histone H3 acetylation","volume":"22","author":"Lee","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R128-20230518","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1093\/hmg\/ddy143","article-title":"The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model","volume":"27","author":"Lee","year":"2018","journal-title":"Hum Mol Genet"},{"key":"R129-20230518","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40035-020-00217-y","article-title":"Targeting \u03b1-synuclein by PD03 AFFITOPE\u00aeand Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy:clinical relevance","volume":"9","author":"Lemos","year":"2020","journal-title":"Transl Neurodegener"},{"key":"R130-20230518","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S1474-4422(19)30141-3","article-title":"Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA):a randomised, double-blind, placebo-controlled trial","volume":"18","author":"Levin","year":"2019","journal-title":"Lancet Neurol"},{"key":"R131-20230518","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-3-19","article-title":"In vivo silencing of alpha-synuclein using naked siRNA","volume":"3","author":"Lewis","year":"2008","journal-title":"Mol Neurodegener"},{"key":"R132-20230518","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1038\/s41467-018-05971-2","article-title":"Cryo-EM of full-length \u03b1-synuclein reveals fibril polymorphs with a common structural kernel","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun"},{"key":"R133-20230518","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm1746","article-title":"Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation","volume":"14","author":"Li","year":"2008","journal-title":"Nat Med"},{"key":"R134-20230518","doi-asserted-by":"crossref","first-page":"680026","DOI":"10.3389\/fnins.2021.680026","article-title":"Squalamine and its derivatives modulate the aggregation of amyloid-\u03b2and \u03b1-synuclein and suppress the toxicity of their oligomers","volume":"15","author":"Limbocker","year":"2021","journal-title":"Front Neurosci"},{"key":"R135-20230518","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0002-9440(10)65722-7","article-title":"Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes","volume":"153","author":"Lippa","year":"1998","journal-title":"Am J Pathol"},{"key":"R136-20230518","first-page":"322","article-title":"\u03b1-synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum-Golgi compartment","volume":"18","author":"Liu","year":"2018","journal-title":"Mol Med Rep"},{"key":"R137-20230518","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.1523\/JNEUROSCI.1659-16.2016","article-title":"Monomeric alpha-synuclein exerts a physiological role on brain ATP synthase","volume":"36","author":"Ludtmann","year":"2016","journal-title":"J Neurosci"},{"key":"R138-20230518","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1038\/s41467-018-04422-2","article-title":"2018 \u03b1-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease","volume":"9","author":"Ludtmann","journal-title":"Nat Commun"},{"key":"R139-20230518","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1073\/pnas.0908005106","article-title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","volume":"106","author":"Luk","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R140-20230518","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1084\/jem.20112457","article-title":"Intracerebral inoculation of pathological \u03b1-synuclein initiates a rapidly progressive neurodegenerative \u03b1-synucleinopathy in mice","volume":"209","author":"Luk","year":"2012","journal-title":"J Exp Med"},{"key":"R141-20230518","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-016-0072-9","article-title":"Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease","volume":"11","author":"Majbour","year":"2016","journal-title":"Mol Neurodegener"},{"key":"R142-20230518","doi-asserted-by":"crossref","first-page":"13621","DOI":"10.1074\/jbc.M109.074617","article-title":"Lysosomal degradation of \u03b1-synuclein in vivo","volume":"285","author":"Mak","year":"2010","journal-title":"J Biol Chem"},{"key":"R143-20230518","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41467-021-21027-4","article-title":"The docking of synaptic vesicles on the presynaptic membrane induced by \u03b1-synuclein is modulated by lipid composition","volume":"12","author":"Man","year":"2021","journal-title":"Nat Commun"},{"key":"R144-20230518","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13024-015-0008-9","article-title":"Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy","volume":"10","author":"Mandler","year":"2015","journal-title":"Mol Neurodegener"},{"key":"R145-20230518","doi-asserted-by":"crossref","first-page":"C901","DOI":"10.1152\/ajpcell.00292.2014","article-title":"Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis:an update","volume":"307","author":"Mani\u00e9","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"R146-20230518","doi-asserted-by":"crossref","first-page":"aah3374","DOI":"10.1126\/science.aah3374","article-title":"Pathological \u03b1-synuclein transmission initiated by binding lymphocyte-activation gene 3","volume":"353","author":"Mao","year":"2016","journal-title":"Science"},{"key":"R147-20230518","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","article-title":"Synuclein:a neuron-specific protein localized to the nucleus and presynaptic nerve terminal","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J Neurosci"},{"key":"R148-20230518","first-page":"201","article-title":"Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease","volume":"148","author":"Masliah","year":"1996","journal-title":"Am J Pathol"},{"key":"R149-20230518","doi-asserted-by":"crossref","first-page":"e19338","DOI":"10.1371\/journal.pone.0019338","article-title":"Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease","volume":"6","author":"Masliah","year":"2011","journal-title":"PLoS One"},{"key":"R150-20230518","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s40478-014-0088-8","article-title":"Pathological alpha-synuclein propagates through neural networks","volume":"2","author":"Masuda-Suzukake","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"R151-20230518","doi-asserted-by":"crossref","first-page":"e85443","DOI":"10.1371\/journal.pone.0085443","article-title":"Alzheimer's Disease Neuroimaging Initiative. Effects of baseline CSF \u03b1-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease","volume":"8","author":"Mattsson","year":"2013","journal-title":"PLoS One"},{"key":"R152-20230518","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","article-title":"\u03b1-Synucleinopathy phenotypes","volume":"20","author":"McCann","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"R153-20230518","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies:Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"R154-20230518","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/biom11101419","article-title":"Structural and functional insights into \u03b1-synuclein fibril polymorphism","volume":"11","author":"Mehra","year":"2021","journal-title":"Biomolecules"},{"key":"R155-20230518","doi-asserted-by":"crossref","first-page":"852003","DOI":"10.3389\/fneur.2022.852003","article-title":"Alpha-synuclein targeting therapeutics for Parkinson's disease and related synucleinopathies","volume":"13","author":"Menon","year":"2022","journal-title":"Front Neurol"},{"key":"R156-20230518","doi-asserted-by":"crossref","first-page":"104619","DOI":"10.1016\/j.nbd.2019.104619","article-title":"Optimizing intracellular antibodies (intrabodies\/nanobodies) to treat neurodegenerative disorders","volume":"134","author":"Messer","year":"2020","journal-title":"Neurobiol Dis"},{"key":"R157-20230518","doi-asserted-by":"crossref","first-page":"19213","DOI":"10.1074\/jbc.M110551200","article-title":"Biochemical characterization of the core structure of alpha-synuclein filaments","volume":"277","author":"Miake","year":"2002","journal-title":"J Biol Chem"},{"key":"R158-20230518","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1126\/science.aaf3934","article-title":"Beta2- Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson's disease","volume":"357","author":"Mittal","year":"2017","journal-title":"Science"},{"key":"R159-20230518","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-017-0154-3","article-title":"Therapeutic potential of autophagy-enhancing agents in Parkinson's disease","volume":"12","author":"Moors","year":"2017","journal-title":"Mol Neurodegener"},{"key":"R160-20230518","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12035-016-0317-1","article-title":"Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins:implications for neurodegenerative disorders","volume":"55","author":"Motyl","year":"2018","journal-title":"Mol Neurobiol"},{"key":"R161-20230518","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/brain\/awt367","article-title":"Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease","volume":"137","author":"Murphy","year":"2014","journal-title":"Brain"},{"key":"R162-20230518","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00401-003-0811-1","article-title":"Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy","volume":"107","author":"Nishie","year":"2004","journal-title":"Acta Neuropathol"},{"key":"R163-20230518","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria:in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"R164-20230518","doi-asserted-by":"crossref","first-page":"e13296","DOI":"10.1111\/acel.13296","article-title":"Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice","volume":"20","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"key":"R165-20230518","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.celrep.2015.01.060","article-title":"Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism","volume":"10","author":"Osterberg","year":"2015","journal-title":"Cell Rep"},{"key":"R166-20230518","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JPD-160867","article-title":"Nilotinib Effects in Parkinson's disease and Dementia with Lewy bodies","volume":"6","author":"Pagan","year":"2016","journal-title":"J Parkinsons Dis"},{"key":"R167-20230518","doi-asserted-by":"crossref","first-page":"e00470","DOI":"10.1002\/prp2.470","article-title":"Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease","volume":"7","author":"Pagan","year":"2019","journal-title":"Pharmacol Res Perspect"},{"key":"R168-20230518","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMoa2202867","article-title":"Trial of prasinezumab in early-stage Parkinson's disease","volume":"387","author":"Pagano","year":"2022","journal-title":"N Engl J Med"},{"key":"R169-20230518","doi-asserted-by":"crossref","first-page":"34690","DOI":"10.1074\/jbc.M111.261321","article-title":"Hsc70 protein interaction with soluble and fibrillar alpha-synuclein","volume":"286","author":"Pemberton","year":"2011","journal-title":"J Biol Chem"},{"key":"R170-20230518","doi-asserted-by":"crossref","first-page":"E1009","DOI":"10.1073\/pnas.1610586114","article-title":"A natural product inhibits the initiation of \u03b1-synuclein aggregation and suppresses its toxicity","volume":"114","author":"Perni","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R171-20230518","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1021\/acschembio.8b00466","article-title":"Multistep inhibition of \u03b1-synuclein aggregation and toxicity in vitro and in vivo by trodusquemine","volume":"13","author":"Perni","year":"2018","journal-title":"ACS Chem Biol"},{"key":"R172-20230518","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.bpj.2012.04.050","article-title":"Fibrillar \u03b1-synuclein and huntingtin exon 1 assemblies are toxic to the cells","volume":"102","author":"Pieri","year":"2012","journal-title":"Biophys J"},{"key":"R173-20230518","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1073\/pnas.1713129115","article-title":"\u03b1-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies","volume":"115","author":"Prots","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R174-20230518","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00702-013-1133-7","article-title":"Cerebellar and parkinsonian phenotypes in multiple system atrophy:similarities, differences and survival","volume":"121","author":"Qin","year":"2014","journal-title":"J Neural Transm"},{"key":"R175-20230518","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.arr.2014.01.004","article-title":"Ageing and Parkinson's disease:why is advancing age the biggest risk factor?","volume":"14","author":"Reeve","year":"2014","journal-title":"Ageing Res Rev"},{"key":"R176-20230518","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12264-017-0159-5","article-title":"Premotor diagnosis of Parkinson's disease","volume":"33","author":"Reichmann","year":"2017","journal-title":"Neurosci Bull"},{"key":"R177-20230518","doi-asserted-by":"crossref","first-page":"19366","DOI":"10.1021\/ja2029848","article-title":"Mechanism of membrane interaction and disruption by \u03b1-synuclein","volume":"133","author":"Reynolds","year":"2011","journal-title":"J Am Chem Soc"},{"key":"R178-20230518","doi-asserted-by":"crossref","first-page":"e0171925","DOI":"10.1371\/journal.pone.0171925","article-title":"\u03b1-Synuclein increases \u03b2-amyloid secretion by promoting \u03b2-\/\u03b3-secretase processing of APP","volume":"12","author":"Roberts","year":"2017","journal-title":"PLoS One"},{"key":"R179-20230518","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/brain\/awy146","article-title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","volume":"141","author":"Robinson","year":"2018","journal-title":"Brain"},{"key":"R180-20230518","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/cbic.201402281","article-title":"Alpha-synuclein binds to the inner membrane of mitochondria in an \u03b1-helical conformation","volume":"15","author":"Robotta","year":"2014","journal-title":"Chembiochem"},{"key":"R181-20230518","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"R182-20230518","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00702-013-1133-7","article-title":"Cerebellar and parkinsonian phenotypes in multiple system atrophy:similarities, differences and survival","volume":"121","author":"Roncevic","year":"2014","journal-title":"J Neural Transm (Vienna)"},{"key":"R183-20230518","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/jnc.13743","article-title":"Proteolysis of \u03b1-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology","volume":"140","author":"Sacino","year":"2017","journal-title":"J Neurochem"},{"key":"R184-20230518","doi-asserted-by":"crossref","first-page":"e1009359","DOI":"10.1371\/journal.pgen.1009359","article-title":"\u03b1-synuclein impairs autophagosome maturation through abnormal actin stabilization","volume":"17","author":"Sarkar","year":"2021","journal-title":"PLoS Gen"},{"key":"R185-20230518","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/mds.26878","article-title":"First-in-human assessment of PRX002, an anti-\u03b1-synuclein monoclonal antibody, in healthy volunteers","volume":"32","author":"Schenk","year":"2017","journal-title":"Mov Disord"},{"key":"R186-20230518","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson's disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov Disord"},{"key":"R187-20230518","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/mds.26377","article-title":"Active immunization therapies for Parkinson's disease and multiple system atrophy","volume":"31","author":"Schneeberger","year":"2016","journal-title":"Mov Disord"},{"key":"R188-20230518","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","article-title":"ER stress and the unfolded protein response","volume":"569","author":"Schr\u00f6der","year":"2005","journal-title":"Mutat Res"},{"key":"R189-20230518","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1385\/MB:34:2:279","article-title":"The unfolded protein response","volume":"34","author":"Schr\u00f6der","year":"2006","journal-title":"Mol Biotechnol"},{"key":"R190-20230518","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41586-020-2317-6","article-title":"Structures of \u03b1-synuclein filaments from multiple system atrophy","volume":"585","author":"Schweighauser","year":"2020","journal-title":"Nature"},{"key":"R191-20230518","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.parkreldis.2018.02.022","article-title":"Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease","volume":"50","author":"Schwiertz","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"R192-20230518","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neubiorev.2009.10.005","article-title":"Motor control and aging:links to age-related brain structural, functional, and biochemical effects","volume":"34","author":"Seidler","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"R193-20230518","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1073\/pnas.97.9.4897","article-title":"Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation","volume":"97","author":"Serpell","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R194-20230518","doi-asserted-by":"crossref","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R195-20230518","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/mds.23774","article-title":"Lysosomal storage disorders and Parkinson's disease:Gaucher disease and beyond","volume":"26","author":"Shachar","year":"2011","journal-title":"Mov Disord"},{"key":"R196-20230518","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2017.05.026","article-title":"Physico-pathologic mechanisms involved in neurodegeneration:misfolded protein-plasma membrane interactions","volume":"95","author":"Shrivastava","year":"2017","journal-title":"Neuron"},{"key":"R197-20230518","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.bpj.2020.01.022","article-title":"Differential membrane binding and seeding of distinct \u03b1-synuclein fibrillar polymorphs","volume":"118","author":"Shrivastava","year":"2020","journal-title":"Biophys J"},{"key":"R198-20230518","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/jamaneurol.2020.4725","article-title":"Efficacy of nilotinib in patients with moderately advanced Parkinson disease:a randomized clinical trial","volume":"78","author":"Simuni","year":"2021","journal-title":"JAMA Neurol"},{"key":"R199-20230518","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/362318a0","article-title":"SNAP receptors implicated in vesicle targeting and fusion","volume":"362","author":"S\u00f6llner","year":"1993","journal-title":"Nature"},{"key":"R200-20230518","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40478-016-0410-8","article-title":"Anti-\u03b1-synuclein immunotherapy reduces \u03b1-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy","volume":"5","author":"Spencer","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"R201-20230518","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"\u03b1-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R202-20230518","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1039\/C1MB05293D","article-title":"Kinetic measurements give new insights into lipid membrane permeabilization by \u03b1-synuclein oligomers","volume":"8","author":"St\u00f6ckl","year":"2012","journal-title":"Mol Biosyst"},{"key":"R203-20230518","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s12035-012-8331-4","article-title":"\u03b1-Synuclein oligomers:an amyloid pore?Insights into mechanisms of \u03b1-synuclein oligomer-lipid interactions","volume":"47","author":"St\u00f6ckl","year":"2013","journal-title":"Mol Neurobiol"},{"key":"R204-20230518","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1038\/s41467-019-13564-w","article-title":"Structural heterogeneity of \u03b1-synuclein fibrils amplified from patient brain extracts","volume":"10","author":"Stroh\u00e4ker","year":"2019","journal-title":"Nat Commun"},{"key":"R205-20230518","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"Sudhof","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"R206-20230518","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.3390\/ijms19092486","article-title":"Investigation of \u03b1-synuclein amyloid fibrils using the fluorescent probe thioflavin T","volume":"19","author":"Sulatskaya","year":"2018","journal-title":"Int J Mol Sci"},{"key":"R207-20230518","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1111\/febs.14607","article-title":"Determinants of dopaminergic neuron loss in Parkinson's disease","volume":"285","author":"Surmeier","year":"2018","journal-title":"FEBS J"},{"key":"R208-20230518","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1007\/s00018-017-2541-x","article-title":"Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production","volume":"74","author":"Tapias","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"R209-20230518","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/mds.28774","article-title":"Cellular prion protein mediates \u03b1-synuclein uptake, localization, and toxicity in vitro and in vivo","volume":"37","author":"Thom","year":"2022","journal-title":"Mov Disord"},{"key":"R210-20230518","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00018-022-04240-2","article-title":"Initiation and progression of \u03b1-synuclein pathology in Parkinson's disease","volume":"79","author":"Tofaris","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"R211-20230518","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1016\/j.bbamem.2012.07.007","article-title":"Alpha-synuclein pore forming activity upon membrane association","volume":"1818","author":"Tosatto","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"R212-20230518","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.celrep.2014.05.033","article-title":"\u0391-synuclein immunotherapy blocks uptake and templated propagation of misfolded \u03b1-synuclein and neurodegeneration","volume":"7","author":"Tran","year":"2014","journal-title":"Cell Rep"},{"key":"R213-20230518","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1523\/JNEUROSCI.1871-20.2020","article-title":"\u03b1-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR activity in neurons, thus contributing to synapse loss","volume":"41","author":"Trudler","year":"2021","journal-title":"J Neurosci"},{"key":"R214-20230518","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nsmb.3194","article-title":"Solid-state NMR structure of a pathogenic fibril of full-length human \u03b1-synuclein","volume":"23","author":"Tuttle","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"R215-20230518","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-019-0320-x","article-title":"Alpha-synuclein in the pathophysiology of Alzheimer's disease","volume":"14","author":"Twohig","year":"2019","journal-title":"Mol Neurodegener"},{"key":"R216-20230518","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.90.23.11282","article-title":"Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease","volume":"90","author":"Ueda","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R217-20230518","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-4159.2007.04764.x","article-title":"Neuropathology, biochemistry, and biophysics of \u03b1-synuclein aggregation","volume":"103","author":"Uversky","year":"2007","journal-title":"J Neurochem"},{"issue":"Suppl 1(Suppl 1)","key":"R218-20230518","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/jnc.13529","article-title":"Therapeutic approaches in Parkinson's disease and related disorders","volume":"139","author":"Valera","year":"2016","journal-title":"J Neurochem"},{"key":"R219-20230518","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-019-02040-w","article-title":"Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats","volume":"138","author":"Van","year":"2019","journal-title":"Acta Neuropathol"},{"key":"R220-20230518","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/brain\/awab061","article-title":"Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats","volume":"144","author":"Van Den Berge","year":"2021","journal-title":"Brain"},{"key":"R221-20230518","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3390\/cells10071694","article-title":"Alpha-synuclein preformed fibrils induce cellular senescence in Parkinson's disease models","volume":"10","author":"Verma","year":"2021","journal-title":"Cells"},{"key":"R222-20230518","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1073\/pnas.0712179105","article-title":"The fold of \u03b1-synuclein fibrils","volume":"105","author":"Vilar","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R223-20230518","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1021\/bi0102398","article-title":"Vesicle permeabilization by protofibrillar alpha-synuclein:implications for the pathogenesis and treatment of Parkinson's disease","volume":"40","author":"Volles","year":"2001","journal-title":"Biochemistry"},{"key":"R224-20230518","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous \u03b1-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"R225-20230518","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous alpha-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous alpha-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat Protoc"},{"key":"R226-20230518","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40478-019-0696-4","article-title":"Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration","volume":"7","author":"Wang","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"R227-20230518","doi-asserted-by":"crossref","first-page":"108843","DOI":"10.1016\/j.biopha.2019.108843","article-title":"Progress of immunotherapy of anti-\u03b1-synuclein in Parkinson's disease","volume":"115","author":"Wang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"R228-20230518","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.nbd.2018.10.016","article-title":"Development of an aggregate-selective, human-derived \u03b1-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models","volume":"124","author":"Weihofen","year":"2019","journal-title":"Neurobiol Dis"},{"key":"R229-20230518","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/brain\/117.4.835","article-title":"Clinical features and natural history of multiple system atrophy. An analysis of 100 cases","volume":"117","author":"Wenning","year":"1994","journal-title":"Brain"},{"key":"R230-20230518","doi-asserted-by":"crossref","first-page":"591475","DOI":"10.3389\/fnagi.2021.591475","article-title":"Exogenous alpha-synuclein evoked parkin downregulation promotes mitochondrial dysfunction in neuronal cells. Implications for Parkinson's disease pathology","volume":"13","author":"Wilkaniec","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"R231-20230518","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"\u03b1-Synuclein impairs macroautophagy:implications for Parkinson's disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J Cell Biol"},{"key":"R232-20230518","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41586-022-05319-3","article-title":"Structures of \u03b1-synuclein filaments from human brains with Lewy pathology","volume":"610","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"R233-20230518","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1038\/s41598-021-90503-0","article-title":"Cooperative inhibition of SNARE-mediated vesicle fusion by \u03b1-synuclein monomers and oligomers","volume":"11","author":"Yoo","year":"2021","journal-title":"Sci Rep"},{"key":"R234-20230518","doi-asserted-by":"crossref","first-page":"14369","DOI":"10.1021\/bi701275p","article-title":"Helical \u03b1-synuclein forms highly conductive ion channels","volume":"46","author":"Zakharov","year":"2007","journal-title":"Biochemistry"},{"key":"R235-20230518","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1073\/pnas.1905057117","article-title":"Translation of the intrinsically disordered protein alpha-synuclein is inhibited by a small molecule targeting its structured mRNA","volume":"117","author":"Zhang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R236-20230518","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.nbd.2019.01.004","article-title":"Long-term RNAi knockdown of alpha-synuclein in the adult rat substantia nigra without neurodegeneration","volume":"125","author":"Zharikov","year":"2019","journal-title":"Neurobiol Dis"},{"key":"R237-20230518","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.09.012","article-title":"Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease","volume":"155","author":"Zucca","year":"2017","journal-title":"Prog Neurobiol"},{"key":"R238-20230518","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuron.2017.12.012","article-title":"Reversible conformational conversion of \u03b1-synuclein into toxic assemblies by glucosylceramide","volume":"97","author":"Zunke","year":"2018","journal-title":"Neuron"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.371345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:08:39Z","timestamp":1787760519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.371345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":238,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.371345","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}