{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:09Z","timestamp":1787761869210,"version":"build-2784847793"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.4103\/1673-5374.371369","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T10:20:01Z","timestamp":1678530001000},"page":"2459-2465","source":"Crossref","is-referenced-by-count":12,"title":["Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy"],"prefix":"10.4103","volume":"18","author":[{"given":"Junzi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"B1-20230518","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.cub.2021.01.019","article-title":"Medial septum glutamatergic neurons control wakefulness through a septo-hypothalamic circuit","volume":"31","author":"An","year":"2021","journal-title":"Curr Biol"},{"key":"B2-20230518","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nn992","article-title":"Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice","volume":"6","author":"Anagnostaras","year":"2003","journal-title":"Nat Neurosci"},{"key":"B3-20230518","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuron.2016.09.006","article-title":"Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline","volume":"91","author":"Ballinger","year":"2016","journal-title":"Neuron"},{"key":"B4-20230518","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.stem.2017.10.003","article-title":"Long-range GABAergic inputs regulate neural stem cell quiescence and control adult hippocampal neurogenesis","volume":"21","author":"Bao","year":"2017","journal-title":"Cell Stem Cell"},{"key":"B5-20230518","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1212\/01.wnl.0000345969.57574.f5","article-title":"Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy","volume":"72","author":"Bernhardt","year":"2009","journal-title":"Neurology"},{"key":"B6-20230518","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.aad5252","article-title":"Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation","volume":"352","author":"Boyce","year":"2016","journal-title":"Science"},{"key":"B7-20230518","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.aan4074","article-title":"Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory","volume":"359","author":"Bui","year":"2018","journal-title":"Science"},{"key":"B8-20230518","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1017\/S1355617711001421","article-title":"Volume of the human septal forebrain region is a predictor of source memory accuracy","volume":"18","author":"Butler","year":"2012","journal-title":"J Int Neuropsychol Soc"},{"key":"B9-20230518","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1212\/WNL.0b013e31827f0ed7","article-title":"Septal nuclei enlargement in human temporal lobe epilepsy without mesial temporal sclerosis","volume":"80","author":"Butler","year":"2013","journal-title":"Neurology"},{"key":"B10-20230518","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuroimage.2014.04.026","article-title":"Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology","volume":"97","author":"Butler","year":"2014","journal-title":"Neuroimage"},{"key":"B11-20230518","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/epi.14614","article-title":"Alterations in the hippocampal-thalamic pathway underlying secondarily generalized tonic-clonic seizures in mesial temporal lobe epilepsy:A diffusion tensor imaging study","volume":"60","author":"Chen","year":"2019","journal-title":"Epilepsia"},{"key":"B12-20230518","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/s41467-021-21476-x","article-title":"Histamine H(1) receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice","volume":"12","author":"Cheng","year":"2021","journal-title":"Nat Commun"},{"key":"B13-20230518","first-page":"47","article-title":"Selective nicotinic acetylcholine receptor agonists:potential therapies for neuropsychiatric disorders with cognitive dysfunction","volume":"9","author":"Cincotta","year":"2008","journal-title":"Curr Opin Investig Drugs"},{"key":"B14-20230518","doi-asserted-by":"crossref","first-page":"e13214","DOI":"10.7554\/eLife.13214","article-title":"Cell type-specific long-range connections of basal forebrain circuit","volume":"5","author":"Do","year":"2016","journal-title":"Elife"},{"key":"B15-20230518","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.mehy.2015.02.016","article-title":"Stimulation of the medial septum should benefit patients with temporal lobe epilepsy","volume":"84","author":"Fisher","year":"2015","journal-title":"Med Hypotheses"},{"key":"B16-20230518","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.cub.2013.07.006","article-title":"Hippocampus-dependent strengthening of targeted memories via reactivation during sleep in humans","volume":"23","author":"Fuentemilla","year":"2013","journal-title":"Curr Biol"},{"key":"B17-20230518","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(18)30454-X","article-title":"Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol"},{"key":"B18-20230518","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2011.04.026","article-title":"Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity","volume":"71","author":"Gu","year":"2011","journal-title":"Neuron"},{"key":"B19-20230518","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jnc.14052","article-title":"Cholinergic modulation of the hippocampal region and memory function","volume":"2","author":"Haam","year":"2017","journal-title":"J Neurochem 142 Suppl"},{"key":"B20-20230518","doi-asserted-by":"crossref","first-page":"E1886","DOI":"10.1073\/pnas.1712538115","article-title":"Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons","volume":"115","author":"Haam","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B21-20230518","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/brain\/awab042","article-title":"Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation","volume":"144","author":"Hristova","year":"2021","journal-title":"Brain"},{"key":"B22-20230518","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/364723a0","article-title":"Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state","volume":"364","author":"Huerta","year":"1993","journal-title":"Nature"},{"key":"B23-20230518","doi-asserted-by":"crossref","first-page":"15951","DOI":"10.1523\/JNEUROSCI.3663-10.2010","article-title":"Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells:relevance for hippocampal theta rhythm","volume":"30","author":"Huh","year":"2010","journal-title":"J Neurosci"},{"key":"B24-20230518","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.brs.2019.01.005","article-title":"Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats","volume":"12","author":"Izadi","year":"2019","journal-title":"Brain Stimul"},{"key":"B25-20230518","doi-asserted-by":"crossref","first-page":"708957","DOI":"10.3389\/fneur.2021.708957","article-title":"Early intervention via stimulation of the medial septal nucleus improves cognition and alters markers of epileptogenesis in pilocarpine-induced epilepsy","volume":"12","author":"Izadi","year":"2021","journal-title":"Front Neurol"},{"key":"B26-20230518","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12264-017-0186-2","article-title":"Volumetric changes in hippocampal subregions and memory performance in mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"34","author":"Ji","year":"2018","journal-title":"Neurosci Bull"},{"key":"B27-20230518","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0140-6736(05)74765-6","article-title":"Cognitive impairment in temporal-lobe epilepsy","volume":"355","author":"Jokeit","year":"2000","journal-title":"Lancet"},{"key":"B28-20230518","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer's disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural Regen Res"},{"key":"B29-20230518","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/jama.2022.3880","article-title":"Antiseizure medications for adults with epilepsy:a review","volume":"327","author":"Kanner","year":"2022","journal-title":"JAMA"},{"key":"B30-20230518","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1474-4422(15)00225-2","article-title":"Comorbidities of epilepsy:current concepts and future perspectives","volume":"15","author":"Keezer","year":"2016","journal-title":"Lancet Neurol"},{"key":"B31-20230518","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.neubiorev.2013.10.011","article-title":"The kainic acid model of temporal lobe epilepsy","volume":"37","author":"L\u00e9vesque","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"B32-20230518","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4103\/1673-5374.337053","article-title":"Anodal transcranial direct current stimulation alleviates cognitive impairment in an APP\/PS1 model of Alzheimer's disease in the preclinical stage","volume":"17","author":"Luo","year":"2022","journal-title":"Neural Regen Res"},{"key":"B33-20230518","year":"2011","journal-title":"Guide for the Care and Use of Laboratory Animals"},{"key":"B34-20230518","author":"Paxinos","year":"2001","journal-title":"The mouse brain in stereotaxic coordinates"},{"key":"B35-20230518","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ana.25762","article-title":"Hippocampal shape is associated with memory deficits in temporal lobe epilepsy","volume":"88","author":"Postma","year":"2020","journal-title":"Ann Neurol"},{"key":"B36-20230518","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1523\/JNEUROSCI.2141-15.2016","article-title":"Optogenetic activation of septal glutamatergic neurons drive hippocampal theta rhythms","volume":"36","author":"Robinson","year":"2016","journal-title":"J Neurosci"},{"key":"B37-20230518","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/brain\/awaa450","article-title":"Closed-loop stimulation of the medial septum terminates epileptic seizures","volume":"144","author":"Takeuchi","year":"2021","journal-title":"Brain"},{"key":"B38-20230518","doi-asserted-by":"crossref","first-page":"8.31.1","DOI":"10.1002\/0471142301.ns0831s69","article-title":"Examining object location and object recognition memory in mice","volume":"69","author":"Vogel-Ciernia","year":"2014","journal-title":"Curr Protoc Neurosci"},{"key":"B39-20230518","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopsych.2004.04.002","article-title":"Hippocampal volume, memory, and cortisol status in major depressive disorder:effects of treatment","volume":"56","author":"Vythilingam","year":"2004","journal-title":"Biol Psychiatry"},{"key":"B40-20230518","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/cns.13617","article-title":"Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm","volume":"27","author":"Wang","year":"2021","journal-title":"CNS Neurosci Ther"},{"key":"B41-20230518","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuron.2017.06.004","article-title":"Depolarized GABAergic signaling in subicular microcircuits mediates generalized seizure in temporal lobe epilepsy","volume":"95","author":"Wang","year":"2017","journal-title":"Neuron"},{"key":"B42-20230518","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.biopsych.2019.11.014","article-title":"Direct septum-hippocampus cholinergic circuit attenuates seizure through driving somatostatin inhibition","volume":"87","author":"Wang","year":"2020","journal-title":"Biol Psychiatry"},{"key":"B43-20230518","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41586-021-03956-8","article-title":"5-HT modulation of a medial septal circuit tunes social memory stability","volume":"599","author":"Wu","year":"2021","journal-title":"Nature"},{"key":"B44-20230518","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.4103\/1673-5374.300447","article-title":"Entacapone promotes hippocampal neurogenesis in mice","volume":"16","author":"Yoo","year":"2021","journal-title":"Neural Regen Res"},{"key":"B45-20230518","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/nm.4413","article-title":"Epigenetic suppression of hippocampal calbindin-D28k by \u0394FosB drives seizure-related cognitive deficits","volume":"23","author":"You","year":"2017","journal-title":"Nat Med"},{"key":"B46-20230518","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.cell.2018.04.014","article-title":"Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain","volume":"173","author":"Zhu","year":"2018","journal-title":"Cell"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.371369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:08:38Z","timestamp":1787760518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.371369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.371369","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}