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In dividing cells, kinesin superfamily protein 2A is involved in mitotic progression, spindle assembly, and chromosome segregation. In postmitotic neurons, it is required for axon\/dendrite specification and extension, neuronal migration, connectivity, and survival. Humans with kinesin superfamily protein 2A mutations suffer from a variety of malformations of cortical development, epilepsy, autism spectrum disorder, and neurodegeneration. In this review, we discuss how kinesin superfamily protein 2A regulates neuronal development and function, and how its deregulation causes neurodevelopmental and neurological disorders.<\/jats:p>","DOI":"10.4103\/1673-5374.375298","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T08:10:01Z","timestamp":1685002201000},"page":"375-379","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Connecting neurodevelopment to neurodegeneration: a spotlight on the role of kinesin superfamily protein 2A (KIF2A)"],"prefix":"10.4103","volume":"19","author":[{"given":"Nuria","family":"Ruiz-Reig","sequence":"first","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, Institute of neuroscience, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Hakanen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de 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