{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:46:24Z","timestamp":1791996384280,"version":"4.4.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202403000-00041\/inline-graphic1\/v\/2023-09-27T141015Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>Vascular etiology is the second most prevalent cause of cognitive impairment globally. Endothelin-1, which is produced and secreted by endothelial cells and astrocytes, is implicated in the pathogenesis of stroke. However, the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood. Here, using mice in which astrocytic endothelin-1 was overexpressed, we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia (1 hour of ischemia; 7 days, 28 days, or 3 months of reperfusion). We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion. Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6, which were differentially expressed in the brain, were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke. Moreover, the levels of the enriched differentially expressed proteins were closely related to lipid metabolism, as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis. Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine, sphingomyelin, and phosphatidic acid. Overall, this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.<\/jats:p>","DOI":"10.4103\/1673-5374.380906","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T13:05:54Z","timestamp":1691759154000},"page":"650-656","source":"Crossref","is-referenced-by-count":18,"title":["Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism"],"prefix":"10.4103","volume":"19","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefang","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiu","family":"Ning","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Sun Yat-Sen School of Medicine, Sun Yat-Sen University, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookja Ki","family":"Chung","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology, Macao Special Administration Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhen","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Sun Yat-Sen School of Medicine, Sun Yat-Sen University, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8264-9713","authenticated-orcid":false,"given":"Xiao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"R1-20230927","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1126\/science.1248903","article-title":"Hippocampal neurogenesis regulates forgetting during adulthood and infancy","volume":"344","author":"Akers","year":"2014","journal-title":"Science"},{"key":"R2-20230927","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"R3-20230927","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/antiox7120172","article-title":"The role of peroxiredoxin 6 in cell signaling","volume":"7","author":"Arevalo","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"R4-20230927","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fncel.2019.00212","article-title":"Lipid metabolism crosstalk in the brain:glia and neurons","volume":"13","author":"Barber","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"R5-20230927","doi-asserted-by":"crossref","first-page":"e0124521","DOI":"10.1371\/journal.pone.0124521","article-title":"Using the Morris water maze to assess spatial learning and memory in weanling mice","volume":"10","author":"Barnhart","year":"2015","journal-title":"PLoS One"},{"key":"R6-20230927","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bbr.2013.05.034","article-title":"Impaired long-term memory retention:common denominator for acutely or genetically reduced hippocampal neurogenesis in adult mice","volume":"252","author":"Ben Abdallah","year":"2013","journal-title":"Behav Brain Res"},{"key":"R7-20230927","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.expneurol.2006.09.006","article-title":"Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse","volume":"203","author":"Bou\u00ebt","year":"2007","journal-title":"Exp Neurol"},{"key":"R8-20230927","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.stem.2020.04.002","article-title":"FASN-dependent lipid metabolism links neurogenic stem\/progenitor cell activity to learning and memory deficits","volume":"27","author":"Bowers","year":"2020","journal-title":"Cell Stem Cell"},{"key":"R9-20230927","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10874","article-title":"Transient expression of doublecortin during adult neurogenesis","volume":"467","author":"Brown","year":"2003","journal-title":"J Comp Neurol"},{"key":"R10-20230927","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-psych-010814-015006","article-title":"Adult neurogenesis:beyond learning and memory","volume":"66","author":"Cameron","year":"2015","journal-title":"Annu Rev Psychol"},{"key":"R11-20230927","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12974-019-1597-y","article-title":"Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2\/Stat3 pathway after stroke","volume":"16","author":"Cheng","year":"2019","journal-title":"J Neuroinflammation"},{"key":"R12-20230927","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00401-017-1691-0","article-title":"Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease","volume":"133","author":"Drummond","year":"2017","journal-title":"Acta Neuropathol"},{"key":"R13-20230927","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1006\/bbrc.2000.2354","article-title":"Endothelin-1 induces NAD(P)H oxidase in human endothelial cells","volume":"269","author":"Duerrschmidt","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"R14-20230927","doi-asserted-by":"crossref","first-page":"e246","DOI":"10.1371\/journal.pbio.0060246","article-title":"The timing of differentiation of adult hippocampal neurons is crucial for spatial memory","volume":"6","author":"Farioli-Vecchioli","year":"2008","journal-title":"PLoS Biol"},{"key":"R15-20230927","doi-asserted-by":"crossref","first-page":"R691","DOI":"10.1152\/ajpregu.00427.2015","article-title":"Endothelin, sex, and pregnancy:unique considerations for blood pressure control in females","volume":"310","author":"Gillis","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R16-20230927","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1161\/STROKEAHA.115.010091","article-title":"Rosiglitazone promotes white matter integrity and long-term functional recovery after focal cerebral ischemia","volume":"46","author":"Han","year":"2015","journal-title":"Stroke"},{"key":"R17-20230927","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1038\/jcbfm.2015.109","article-title":"Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion","volume":"35","author":"Hung","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"R18-20230927","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/0006-2952(92)90545-T","article-title":"Suppressive effects of the endothelin receptor (ETA) antagonist BQ-123 on ET-1-induced reduction of lipoprotein lipase activity in 3T3-L1 adipocytes","volume":"44","author":"Ishida","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"R19-20230927","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/oby.2006.53","article-title":"Effect of endothelin-1 on lipolysis in rat adipocytes","volume":"14","author":"Juan","year":"2006","journal-title":"Obesity (Silver Spring, Md)"},{"key":"R20-20230927","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121654","article-title":"Early stroke induces long-term impairment of adult neurogenesis accompanied by hippocampal-mediated cognitive decline","volume":"8","author":"Kathner-Schaffert","year":"2019","journal-title":"Cells"},{"key":"R21-20230927","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1146\/annurev.pharmtox.41.1.851","article-title":"Endothelin system:the double-edged sword in health and disease","volume":"41","author":"Kedzierski","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R22-20230927","doi-asserted-by":"crossref","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the adult hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"R23-20230927","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0006-8993(02)04243-9","article-title":"Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders","volume":"967","author":"Krapfenbauer","year":"2003","journal-title":"Brain Res"},{"key":"R24-20230927","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.STR.28.10.1951","article-title":"Endothelin in cerebrospinal fluid and plasma of patients in the early stage of ischemic stroke","volume":"28","author":"Lampl","year":"1997","journal-title":"Stroke"},{"key":"R25-20230927","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.12.006","article-title":"Hippocampal neurogenesis:Learning to remember","volume":"138-140","author":"Lazarov","year":"2016","journal-title":"Prog Neurobiol"},{"key":"R26-20230927","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semcdb.2020.07.017","article-title":"Lipid metabolism in astrocytic structure and function","volume":"112","author":"Lee","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"R27-20230927","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1007\/s12035-021-02427-5","article-title":"The roles of peroxiredoxin 6 in brain diseases","volume":"58","author":"Liao","year":"2021","journal-title":"Mol Neurobiol"},{"key":"R28-20230927","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.jcbfm.9600108","article-title":"Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet","volume":"25","author":"Lo","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"R29-20230927","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/01.CIR.102.19.2434","article-title":"Endothelins and endothelin receptor antagonists:therapeutic considerations for a novel class of cardiovascular drugs","volume":"102","author":"Luscher","year":"2000","journal-title":"Circulation"},{"key":"R30-20230927","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/1673-5374.338998","article-title":"Pointing fingers at blood contact:mechanisms of subventricular zone neural stem cell differentiation","volume":"18","author":"Malik","year":"2023","journal-title":"Neural Regen Res"},{"key":"R31-20230927","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fnins.2015.00458","article-title":"Mechanisms and functional significance of stroke-induced neurogenesis","volume":"9","author":"Marlier","year":"2015","journal-title":"Front Neurosci"},{"key":"R32-20230927","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1540\/jsmr.44.41","article-title":"Relationships among ET-1, PPARgamma, oxidative stress and endothelial dysfunction in diabetic animals","volume":"44","author":"Matsumoto","year":"2008","journal-title":"J Smooth Muscle Res"},{"key":"R33-20230927","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4103\/1673-5374.339007","article-title":"ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC\/RAP1Gap signaling","volume":"17","author":"McMillan","year":"2022","journal-title":"Neural Regen Res"},{"key":"R34-20230927","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12916-017-0779-7","article-title":"Post-stroke dementia - a comprehensive review","volume":"15","author":"Mijajlovi\u0107","year":"2017","journal-title":"BMC Med"},{"key":"R35-20230927","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0278-5846(95)00031-P","article-title":"Endothelin-1-like immunoreactivity in cerebral cortex of Alzheimer-type dementia","volume":"19","author":"Minami","year":"1995","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R36-20230927","doi-asserted-by":"crossref","first-page":"106274","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106274","article-title":"Infectious causes of stroke","volume":"31","author":"Murala","year":"2022","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"R37-20230927","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/01.HYP.24.1.97","article-title":"Endothelin-1 in cerebrospinal fluid in elderly patients with hypertension and dementia","volume":"24","author":"Nakajima","year":"1994","journal-title":"Hypertension"},{"key":"R38-20230927","year":"2011","journal-title":"Guide for the Care and Use of Laboratory Animals"},{"key":"R39-20230927","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144869","article-title":"Regulation of adult neurogenesis in mammalian brain","volume":"21","author":"Niklison-Chirou","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R40-20230927","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.acn.2005.04.001","article-title":"Restrictions of the mini-mental state examination in acute stroke","volume":"20","author":"Nys","year":"2005","journal-title":"Arch Clin Neuropsychol"},{"key":"R41-20230927","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13024-020-00401-8","article-title":"Peroxiredoxin 6 mediates protective function of astrocytes in A\u03b2proteostasis","volume":"15","author":"Pankiewicz","year":"2020","journal-title":"Mol Neurodegener"},{"key":"R42-20230927","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/antiox8030063","article-title":"Peroxiredoxin6 in endothelial signaling","volume":"8","author":"Patel","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"R43-20230927","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fncel.2019.00381","article-title":"Genes and mechanisms involved in the generation and amplification of basal radial glial cells","volume":"13","author":"Penisson","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"R44-20230927","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0:Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"R45-20230927","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-030-74046-7_7","article-title":"An overview of adult neurogenesis","volume":"1331","author":"Ribeiro","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"R46-20230927","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-stroke cognitive impairment and dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ Res"},{"key":"R47-20230927","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"R48-20230927","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0197-0186(93)90082-G","article-title":"Profile of prostaglandins induced by endothelin-1 in human brain capillary endothelium","volume":"23","author":"Stanimirovic","year":"1993","journal-title":"Neurochem Int"},{"key":"R49-20230927","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2012.09.027","article-title":"Lipid peroxidation triggers neurodegeneration:a redox proteomics view into the Alzheimer disease brain","volume":"62","author":"Sultana","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"R50-20230927","first-page":"225","article-title":"Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates","volume":"149","author":"Tonchev","year":"2011","journal-title":"Arch Ital Biol"},{"key":"R51-20230927","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/00001756-200107200-00044","article-title":"Perinatal hypoxia-\/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells","volume":"12","author":"Tsang","year":"2001","journal-title":"Neuroreport"},{"key":"R52-20230927","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update:a report from the american heart association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"R53-20230927","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze:procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"R54-20230927","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23840-3","article-title":"Saturated free fatty acids and association with memory formation","volume":"12","author":"Wallis","year":"2021","journal-title":"Nat Commun"},{"key":"R55-20230927","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"R56-20230927","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.4103\/1673-5374.357910","article-title":"Transient neurogenesis in ischemic cortex from Sox2+astrocytes","volume":"18","author":"Yang","year":"2023","journal-title":"Neural Regen Res"},{"key":"R57-20230927","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1007\/s12035-018-1287-2","article-title":"PRDX6 inhibits neurogenesis through downregulation of WDFY1-mediated TLR4 signal","volume":"56","author":"Yeo","year":"2019","journal-title":"Mol Neurobiol"},{"key":"R58-20230927","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s12035-013-8479-6","article-title":"Acceleration of the development of Alzheimer's disease in amyloid beta-infused peroxiredoxin 6 overexpression transgenic mice","volume":"48","author":"Yun","year":"2013","journal-title":"Mol Neurobiol"},{"key":"R59-20230927","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nlm.2013.01.002","article-title":"Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion","volume":"101","author":"Zhang","year":"2013","journal-title":"Neurobiol Learn Mem"},{"key":"R60-20230927","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"R61-20230927","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1021\/acs.jproteome.8b00818","article-title":"Hippocampal proteomic alteration in triple transgenic mouse model of Alzheimer's disease and implication of PINK 1 regulation in donepezil treatment","volume":"18","author":"Zhou","year":"2019","journal-title":"J Proteome Res"}],"updated-by":[{"DOI":"10.4103\/nrr.nrr-d-24-00356","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000}}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.380906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:18:07Z","timestamp":1787761087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.380906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.380906","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,20]]}}}