{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:55:29Z","timestamp":1793393729583,"version":"4.5.0"},"reference-count":170,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    \u03b1-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons, respectively. Previous works have revealed that intracellular deposition of \u03b1-synuclein and\/or tau causes many neurodegenerative disorders, including Alzheimer\u2019s disease and Parkinson\u2019s disease. Despite intense investigation, the normal physiological functions and roles of \u03b1-synuclein and tau are still unclear, owing to the fact that mice with knockout of either of these proteins do not present apparent phenotypes. Interestingly, the co-occurrence of \u03b1-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies, some of which share similarities in clinical manifestations. Furthermore, the direct interaction of \u03b1-synuclein with tau is considered to promote the fibrillization of each of the proteins\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . On the other hand, our recent findings have revealed that \u03b1-synuclein and tau are cooperatively involved in brain development in a stage-dependent manner. These findings indicate strong cross-talk between the two proteins in physiology and pathology. In this review, we provide a summary of the recent findings on the functional roles of \u03b1-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases. A deep understanding of the interplay between \u03b1-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.382231","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:00:35Z","timestamp":1694257235000},"page":"855-862","source":"Crossref","is-referenced-by-count":28,"title":["Pathological and physiological functional cross-talks of \u03b1-synuclein and tau in the central nervous system"],"prefix":"10.4103","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5249-8918","authenticated-orcid":false,"given":"Mingyue","family":"Jin","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China"},{"name":"Department of Genetic Disease Research, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetic Disease Research, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodie","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyou","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Scientific Research, Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, Guangxi Zhuang Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5451-087X","authenticated-orcid":false,"given":"Shinji","family":"Hirotsune","sequence":"additional","affiliation":[{"name":"Department of Genetic Disease Research, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-1396","authenticated-orcid":false,"given":"Liyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"R1-20230909","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3233\/JAD-2004-6412","article-title":"Demonstration of a role for alpha-synuclein as a functional 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