{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:18Z","timestamp":1787169798160,"version":"build-2736575974"},"reference-count":154,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative stress, an increase in acetylcholinesterase activity, mitochondrial dysfunction, genotoxicity, and neuroinflammation are present in this syndrome, which leads to neurodegeneration. Neurodegenerative pathologies such as Alzheimer\u2019s disease are considered late-onset diseases caused by the complex combination of genetic, epigenetic, and environmental factors. There are two main types of Alzheimer\u2019s disease, known as familial Alzheimer\u2019s disease (onset &lt; 65 years) and late-onset or sporadic Alzheimer\u2019s disease (onset \u2265 65 years). Patients with familial Alzheimer\u2019s disease inherit the disease due to rare mutations on the amyloid precursor protein (\n                    <jats:italic toggle=\"yes\">APP<\/jats:italic>\n                    ), presenilin 1 and 2 (\n                    <jats:italic toggle=\"yes\">PSEN1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">PSEN2<\/jats:italic>\n                    ) genes in an autosomal-dominantly fashion with closely 100% penetrance. In contrast, a different picture seems to emerge for sporadic Alzheimer\u2019s disease, which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its etiology. Importantly, the fundamental pathophysiological mechanisms driving Alzheimer\u2019s disease are interfaced with epigenetic dysregulation. However, the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer\u2019s disease or following injury or stroke in humans. In recent years, there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer\u2019s disease. Through epigenetic mechanisms, such as DNA methylation, non-coding RNAs, histone modification, and chromatin conformation regulation, natural compounds appear to exert neuroprotective effects. While we do not purport to cover every in this work, we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer\u2019s disease-related genes.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.382232","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:00:29Z","timestamp":1694257229000},"page":"846-854","source":"Crossref","is-referenced-by-count":26,"title":["Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer\u2019s agents"],"prefix":"10.4103","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9138-1248","authenticated-orcid":false,"given":"Willian Orlando","family":"Castillo-Ordo\u00f1ez","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Naturales-Exactas y de la Educaci\u00f3n, Departamento de Biolog\u00eda. Universidad del Cauca, Popay\u00e1n-Cauca, Colombia"},{"name":"Departamento de Estudios Psicol\u00f3gicos, Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nohelia","family":"Cajas-Salazar","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Naturales-Exactas y de la Educaci\u00f3n, Departamento de Biolog\u00eda. Universidad del Cauca, Popay\u00e1n-Cauca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Alejandra","family":"Velasco-Reyes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Naturales-Exactas y de la Educaci\u00f3n, Departamento de Biolog\u00eda. Universidad del Cauca, Popay\u00e1n-Cauca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"R1-20230909","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbrc.2012.11.087","article-title":"Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1","volume":"430","author":"Achour","year":"(2013)","journal-title":"Biochem Biophys Res Commun"},{"key":"R2-20230909","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pharmthera.2013.03.010","article-title":"Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease","volume":"139","author":"Adwan","year":"(2013)","journal-title":"Pharmacol Ther"},{"key":"R3-20230909","doi-asserted-by":"crossref","first-page":"105155","DOI":"10.1016\/j.nbd.2020.105155","article-title":"Epigenetic mechanisms underlying enhancer modulation of neuronal identity, neuronal activity and neurodegeneration","volume":"147","author":"Alcal\u00e0-Vida","year":"(2021)","journal-title":"Neurobiol Dis"},{"key":"R4-20230909","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/ng.3441","article-title":"Clock-like mutational processes in human somatic cells","volume":"47","author":"Alexandrov","year":"(2015)","journal-title":"Nat Genet"},{"key":"R5-20230909","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1001\/jamaneurol.2015.0098","article-title":"Effect of cognitive reserve on age-related changes in cerebrospinal fluid biomarkers of Alzheimer disease","volume":"72","author":"Almeida","year":"(2015)","journal-title":"JAMA Neurol"},{"key":"R6-20230909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-022-02067-w","article-title":"The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models","volume":"12","author":"Amelianchik","year":"(2022)","journal-title":"Transl Psychiatry"},{"key":"R7-20230909","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuropharm.2013.07.004","article-title":"Therapeutics of Alzheimer's disease: past, present and future","volume":"76","author":"Anand","year":"(2014)","journal-title":"Neuropharmacology"},{"key":"R8-20230909","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1021\/acschemneuro.1c00295","article-title":"APOE genotype and Alzheimer's disease: The influence of lifestyle and environmental factors","volume":"12","author":"Angelopoulou","year":"(2021)","journal-title":"ACS Chem Neurosci"},{"key":"R9-20230909","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/bmj.38181.418958.BE","article-title":"Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study","volume":"329","author":"Anttila","year":"(2004)","journal-title":"BMJ"},{"key":"R10-20230909","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/biomedicines11020335","article-title":"The future of precision medicine in the cure of Alzheimer's disease","volume":"11","author":"Arafah","year":"(2023)","journal-title":"Biomedicines"},{"key":"R11-20230909","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2012.01.038","article-title":"Epigenetic programming of neurodegenerative diseases by an adverse environment","volume":"1444","author":"Babenko","year":"(2012)","journal-title":"Brain Res"},{"key":"R12-20230909","doi-asserted-by":"crossref","first-page":"899644","DOI":"10.3389\/fneur.2022.899644","article-title":"Whole exome sequencing reveals a novel APOE mutation in a patient with sporadic early-onset Alzheimer's disease","volume":"13","author":"Bagaria","year":"(2022)","journal-title":"Front Neurol"},{"key":"R13-20230909","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.exger.2003.09.009","article-title":"The emerging role of epigenetics in cellular and organismal aging","volume":"38","author":"Bandyopadhyay","year":"(2003)","journal-title":"Exp Gerontol"},{"key":"R14-20230909","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/NEN.0b013e3181af2e46","article-title":"DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain","volume":"68","author":"Barrachina","year":"(2009)","journal-title":"J Neuropathol Exp Neurol"},{"key":"R15-20230909","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mad.2010.02.007","article-title":"Resveratrol, sirtuins and the promise of a DR mimetic","volume":"131","author":"Baur","year":"(2010)","journal-title":"Mech Ageing Dev"},{"key":"R16-20230909","doi-asserted-by":"crossref","first-page":"18265","DOI":"10.1038\/s41598-020-75035-3","article-title":"Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases","volume":"10","author":"Beaver","year":"(2020)","journal-title":"Sci Rep"},{"key":"R17-20230909","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"(2010)","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"R18-20230909","article-title":"The three-dimensional landscape of chromatin accessibility in Alzheimer's disease","author":"Bendl","year":"(2021)","journal-title":"BioRxiv [Preprint]"},{"key":"R19-20230909","doi-asserted-by":"crossref","first-page":"45","DOI":"10.21767\/2472-1158.100079","article-title":"Some news on old concepts and the epigenetics of Alzheimer's disease","volume":"3","author":"Cacabelos","year":"(2017)","journal-title":"J Clin Epigenet"},{"key":"R20-20230909","first-page":"1163","article-title":"Mutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disorders","volume":"10","author":"Cai","year":"(2015)","journal-title":"Clin Interv Aging"},{"key":"R21-20230909","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2015.08.012","article-title":"Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1 and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients","volume":"605","author":"Carboni","year":"(2015)","journal-title":"Neurosci Lett"},{"key":"R22-20230909","article-title":"Epigenetics for drug discovery","author":"Carey","year":"(2015)","journal-title":"ChemMedChem"},{"key":"R24-20230909","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neuro.2016.10.013","article-title":"Galanthamine decreases genotoxicity and cell death induced by \u03b2-amyloid peptide in SH-SY5Y cell line","volume":"57","author":"Castillo","year":"(2016)","journal-title":"Neurotoxicology"},{"key":"R25-20230909","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4103\/1673-5374.208572","article-title":"Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease","volume":"12","author":"Castillo","year":"(2017)","journal-title":"Neural Regen Res"},{"key":"R26-20230909","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mrgentox.2018.06.010","article-title":"Caliphruria subedentata (Amaryllidaceae) decreases genotoxicity and cell death induced by \u03b2-amyloid peptide in SH-SY5Y cell line","volume":"836","author":"Castillo","year":"(2018)","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"key":"R27-20230909","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1007\/s11064-017-2295-8","article-title":"Exploration of the acetylcholinesterase inhibitory activity of some alkaloids from amaryllidaceae family by molecular docking in silico","volume":"42","author":"Castillo-Ord\u00f3\u00f1ez","year":"(2017)","journal-title":"Neurochem Res"},{"key":"R28-20230909","article-title":"Biolog\u00eda del Alzh\u00e9imer Evoluci\u00f3n y demencia","author":"Castillo-Ordo\u00f1ez","year":"(2022)","journal-title":"Editorial Universidad del Cauca, Popay\u00e1n Colombia"},{"key":"R29-20230909","doi-asserted-by":"crossref","first-page":"40364","DOI":"10.1074\/jbc.M509329200","article-title":"SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling","volume":"280","author":"Chen","year":"(2005)","journal-title":"J Biol Chem"},{"key":"R30-20230909","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.prp.2018.11.012","article-title":"Relationship between long non-coding RNAs and Alzheimer's disease: a systematic review","volume":"215","author":"Chen","year":"(2019)","journal-title":"Pathol Res Pract"},{"key":"R31-20230909","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2013.02.021","article-title":"Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients","volume":"34","author":"Chouliaras","year":"(2013)","journal-title":"Neurobiol Aging"},{"key":"R32-20230909","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4088\/JCP.v68n0419","article-title":"A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease","volume":"68","author":"Coon","year":"(2007)","journal-title":"J Clin Psychiatry"},{"key":"R33-20230909","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fgene.2012.00231","article-title":"Non-coding RNA and pseudogenes in neurodegenerative diseases: \u201cThe (un)Usual Suspects\u201c","volume":"3","author":"Costa","year":"(2012)","journal-title":"Front Genet"},{"key":"R34-20230909","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-030-05542-4_2","article-title":"The role of biomarkers in Alzheimer's disease drug development","volume":"1118","author":"Cummings","year":"(2019)","journal-title":"Adv Exp Med Biol"},{"key":"R35-20230909","doi-asserted-by":"crossref","first-page":"e12295","DOI":"10.1002\/trc2.12295","article-title":"Alzheimer's disease drug development pipeline: 2022","volume":"8","author":"Cummings","year":"(2022)","journal-title":"Alzheimers Dement (N Y)"},{"key":"R36-20230909","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1042\/EBC20190034","article-title":"The influence of DNA methylation on monoallelic expression","volume":"63","author":"da Rocha","year":"(2019)","journal-title":"Essays Biochem"},{"key":"R37-20230909","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper","year":"(2016)","journal-title":"Cell"},{"key":"R38-20230909","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.pmbts.2020.10.002","article-title":"Early detection and personalized medicine: Future strategies against Alzheimer's disease","volume":"177","author":"Di Meco","year":"(2021)","journal-title":"Prog Mol Biol Transl Sci"},{"key":"R39-20230909","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.conb.2021.04.006","article-title":"Three-dimensional chromatin organization in brain function and dysfunction","volume":"69","author":"Dileep","year":"(2021)","journal-title":"Curr Opin Neurobiol"},{"key":"R40-20230909","doi-asserted-by":"crossref","first-page":"104614","DOI":"10.1016\/j.archger.2021.104614","article-title":"LncRNA BDNF-AS as ceRNA regulates the miR-9-5p\/BACE1 pathway affecting neurotoxicity in Alzheimer's disease","volume":"99","author":"Ding","year":"(2022)","journal-title":"Arch Gerontol Geriatr"},{"key":"R41-20230909","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-8118-8-4","article-title":"Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle","volume":"8","author":"Engelhardt","year":"(2011)","journal-title":"Fluids Barriers CNS"},{"key":"R42-20230909","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.2042-7158.2012.01536.x","article-title":"In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids","volume":"64","author":"Eriksson","year":"(2012)","journal-title":"J Pharm Pharmacol"},{"key":"R43-20230909","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13024-022-00566-4","article-title":"APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases","volume":"17","author":"Fern\u00e1ndez-Calle","year":"(2022)","journal-title":"Mol Neurodegener"},{"key":"R44-20230909","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pbb.2014.09.005","article-title":"Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats","volume":"126","author":"Fu","year":"(2014)","journal-title":"Pharmacol Biochem Behav"},{"key":"R45-20230909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-28383-8_1","article-title":"Epigenetic modifications in neurological diseases: natural products as epigenetic modulators a treatment strategy","volume":"12","author":"Gangisetty","year":"(2016)","journal-title":"Adv Neurobiol"},{"key":"R46-20230909","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1126\/science.3810169","article-title":"Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease","volume":"235","author":"Goldgaber","year":"(1987)","journal-title":"Science"},{"key":"R47-20230909","doi-asserted-by":"crossref","first-page":"eaal3222","DOI":"10.1126\/science.aal3222","article-title":"An environment-dependent transcriptional network specifies human microglia identity","volume":"356","author":"Gosselin","year":"(2017)","journal-title":"Science"},{"key":"R48-20230909","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"(2009)","journal-title":"Nature"},{"key":"R49-20230909","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.taap.2015.08.010","article-title":"Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death","volume":"288","author":"Guida","year":"(2015)","journal-title":"Toxicol Appl Pharmacol"},{"key":"R50-20230909","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","article-title":"Amyloid \u03b2-peptide is produced by cultured cells during normal metabolism","volume":"359","author":"Haass","year":"(1992)","journal-title":"Nature"},{"key":"R51-20230909","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1517\/13543784.17.2.169","article-title":"Histone deacetylase inhibitors: possible implications for neurodegenerative disorders","volume":"17","author":"Hahnen","year":"(2008)","journal-title":"Expert Opin Investig Drugs"},{"key":"R52-20230909","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1755-5949.2010.00147.x","article-title":"Curcumin and Alzheimer's disease","volume":"16","author":"Hamaguchi","year":"(2010)","journal-title":"CNS Neurosci Ther"},{"key":"R53-20230909","first-page":"2","article-title":"Revisiting the cholinergic hypothesis in alzheimer's disease: emerging evidence from translational and clinical research","volume":"6","author":"Hampel","year":"(2019)","journal-title":"J Prev Alzheimers Dis"},{"key":"R54-20230909","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.gde.2020.12.008","article-title":"The dynamics of chromatin architecture in brain development and function","volume":"67","author":"Harabula","year":"(2021)","journal-title":"Curr Opin Genet Dev"},{"key":"R55-20230909","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jep.2004.02.012","article-title":"Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge","volume":"92","author":"Heinrich","year":"(2004)","journal-title":"J Ethnopharmacol"},{"key":"R56-20230909","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/1673-5374.313016","article-title":"Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease","volume":"17","author":"Hernandez-Sapiens","year":"(2022)","journal-title":"Neural Regen Res"},{"key":"R57-20230909","first-page":"161","article-title":"An intervention study of individual, apoE genotype-based dietary and physical-activity advice: impact on health behavior","volume":"7","author":"Hietaranta-Luoma","year":"(2014)","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"R58-20230909","first-page":"1","article-title":"Multifactorial glial responses and their contributions to Alzheimer's disease continuum","author":"Hijioka","year":"(2023)","journal-title":"Clin Exp Neuroimmunol"},{"key":"R59-20230909","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.3390\/molecules24162939","article-title":"Neuroprotective effects of ginseng phytochemicals: recent perspectives","volume":"24","author":"Huang","year":"(2019)","journal-title":"Molecules"},{"key":"R60-20230909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2022.2141679","article-title":"A comprehensive review on the prevention and regulation of Alzheimer's disease by tea and its active ingredients","author":"Huang","year":"(2022)","journal-title":"Crit Rev Food Sci Nutr"},{"key":"R61-20230909","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1093\/hmg\/6.10.1639","article-title":"The presenilins and Alzheimer's disease","volume":"6","author":"Hutton","year":"(1997)","journal-title":"Hum Mol Genet"},{"key":"R62-20230909","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"(2017)","journal-title":"Exp Mol Med"},{"key":"R63-20230909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0004.2011.01673.x","article-title":"DNA methylation in neurodegenerative disorders: a missing link between genome and environment?","volume":"80","author":"Iraola-Guzm\u00e1n","year":"(2011)","journal-title":"Clin Genet"},{"key":"R64-20230909","doi-asserted-by":"crossref","first-page":"re1","DOI":"10.1126\/stke.3672007re1","article-title":"How do microRNAs regulate gene expression?","volume":"2007","author":"Jackson","year":"(2007)","journal-title":"Sci STKE"},{"key":"R65-20230909","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/jnc.13440","article-title":"Expression of class II histone deacetylases in two mouse models of temporal lobe epilepsy","volume":"136","author":"Jagirdar","year":"(2016)","journal-title":"J Neurochem"},{"key":"R66-20230909","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1568026616666160414124628","article-title":"Epigenetic basis of neuronal and synaptic plasticity","volume":"17","author":"Karpova","year":"(2017)","journal-title":"Curr Top Med Chem"},{"key":"R67-20230909","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/2211536604666150813152620","article-title":"A MicroRNA-BDNF Negative Feedback Signaling Loop in Brain: Implications for Alzheimer's Disease","volume":"4","author":"Keifer","year":"(2015)","journal-title":"Microrna"},{"key":"R68-20230909","doi-asserted-by":"crossref","first-page":"1518.e1","DOI":"10.1016\/j.neurobiolaging.2012.09.017","article-title":"Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population","volume":"34","author":"Kero","year":"(2013)","journal-title":"Neurobiol Aging"},{"key":"R69-20230909","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/jnc.12680","article-title":"The A\u03b2-clearance protein transthyretin, like neprilysin is epigenetically regulated by the amyloid precursor protein intracellular domain","volume":"130","author":"Kerridge","year":"(2014)","journal-title":"J Neurochem"},{"key":"R70-20230909","doi-asserted-by":"crossref","first-page":"107153","DOI":"10.1016\/j.compbiolchem.2019.107153","article-title":"Novel BDNF-regulatory microRNAs in neurodegenerative disorders pathogenesis: An in silico study","volume":"83","author":"Khani-Habibabadi","year":"(2019)","journal-title":"Comput Biol Chem"},{"key":"R71-20230909","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40035-022-00296-z","article-title":"Advances in the development of new biomarkers for Alzheimer's disease","volume":"11","author":"Klyucherev","year":"(2022)","journal-title":"Transl Neurodegener"},{"key":"R72-20230909","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/23808993.2017.1284557","article-title":"The role of epigenomics in personalized medicine","volume":"2","author":"Kronfol","year":"(2017)","journal-title":"Expert Rev Precis Med Drug Dev"},{"key":"R73-20230909","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1038\/emboj.2012.173","article-title":"Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons","volume":"31","author":"Kuhn","year":"(2012)","journal-title":"EMBO J"},{"key":"R74-20230909","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0973-7847.99898","article-title":"Neuroprotective potential of phytochemicals","volume":"6","author":"Kumar","year":"(2012)","journal-title":"Pharmacogn Rev"},{"key":"R75-20230909","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/10408398.2020.1825286","article-title":"Health-promoting role of dietary bioactive compounds through epigenetic modulations: a novel prophylactic and therapeutic approach","volume":"62","author":"Kumari","year":"(2022)","journal-title":"Crit Rev Food Sci Nutr"},{"key":"R76-20230909","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000093478","article-title":"Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study","volume":"22","author":"Laitinen","year":"(2006)","journal-title":"Dement Geriatr Cogn Disord"},{"key":"R77-20230909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.10.013","article-title":"Protective effect of resveratrol against nigrostriatal pathway injury in striatum via JNK pathway","volume":"1654","author":"Li","year":"(2017)","journal-title":"Brain Res"},{"key":"R78-20230909","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.3892\/mmr.2016.5103","article-title":"Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model","volume":"13","author":"Li","year":"(2016)","journal-title":"Mol Med Rep"},{"key":"R79-20230909","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.exger.2010.06.008","article-title":"Effects of galantamine on \u03b2-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells","volume":"45","author":"Li","year":"(2010)","journal-title":"Exp Gerontol"},{"key":"R80-20230909","first-page":"3777021","article-title":"Current progress on neuroprotection induced by artemisia, ginseng, astragalus and ginkgo traditional Chinese medicines for the therapy of Alzheimer's disease","volume":"2022","author":"Li","year":"(2022)","journal-title":"Oxid Med Cell Longev"},{"key":"R81-20230909","doi-asserted-by":"crossref","first-page":"11322","DOI":"10.1038\/srep11322","article-title":"Swedish mutant APP-based BACE1 binding site peptide reduces APP \u03b2-cleavage and cerebral A\u03b2levels in Alzheimer's mice","volume":"5","author":"Li","year":"(2015)","journal-title":"Sci Rep"},{"key":"R82-20230909","doi-asserted-by":"crossref","first-page":"104462","DOI":"10.1016\/j.bioorg.2020.104462","article-title":"Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs)","volume":"106","author":"Linciano","year":"(2021)","journal-title":"Bioorg Chem"},{"key":"R83-20230909","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fgene.2018.00579","article-title":"The epigenetics of Alzheimer's disease: factors and therapeutic implications","volume":"9","author":"Liu","year":"(2018)","journal-title":"Front Genet"},{"key":"R84-20230909","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3389\/fgene.2019.01150","article-title":"DNA methylation cancer biomarkers: translation to the clinic","volume":"10","author":"Locke","year":"(2019)","journal-title":"Front Genet"},{"key":"R85-20230909","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/WNR.0b013e32833e9288","article-title":"Brain plasticity, memory and neurological disorders: an epigenetic perspective","volume":"21","author":"Lockett","year":"(2010)","journal-title":"Neuroreport"},{"key":"R86-20230909","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","article-title":"Aging and neurodegeneration are associated with increased mutations in single human neurons","volume":"359","author":"Lodato","year":"(2018)","journal-title":"Science"},{"key":"R87-20230909","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41380-018-0266-3","article-title":"Novel upregulation of amyloid-\u03b2precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease","volume":"24","author":"Long","year":"(2019)","journal-title":"Mol Psychiatry"},{"key":"R88-20230909","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jama.2019.9879","article-title":"Association of lifestyle and genetic risk with incidence of dementia","volume":"322","author":"Lourida","year":"(2019)","journal-title":"JAMA"},{"key":"R89-20230909","doi-asserted-by":"crossref","first-page":"e103067","DOI":"10.1371\/journal.pone.0103067","article-title":"Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease","volume":"9","author":"Lu","year":"(2014)","journal-title":"PLoS One"},{"key":"R90-20230909","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0002-9440(10)65184-X","article-title":"Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease","volume":"155","author":"Lue","year":"(1999)","journal-title":"Am J Pathol"},{"key":"R91-20230909","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 \u00c5resolution","volume":"389","author":"Luger","year":"(1997)","journal-title":"Nature"},{"key":"R92-20230909","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1074\/jbc.M110.146860","article-title":"Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism","volume":"286","author":"Ma","year":"(2011)","journal-title":"J Biol Chem"},{"key":"R93-20230909","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/jnc.13621","article-title":"Complex regulation of the regulator of synaptic plasticity histone deacetylase 2 in the rodent dorsal horn after peripheral injury","volume":"138","author":"Maiar\u00f9","year":"(2016)","journal-title":"J Neurochem"},{"key":"R94-20230909","doi-asserted-by":"crossref","first-page":"12280","DOI":"10.3390\/ijms222212280","article-title":"Epigenetic mechanisms in memory and cognitive decline associated with aging and Alzheimer's disease","volume":"22","author":"Maity","year":"(2021)","journal-title":"Int J Mol Sci"},{"key":"R95-20230909","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.neurobiolaging.2010.08.017","article-title":"Epigenetic mechanisms in Alzheimer's disease","volume":"32","author":"Mastroeni","year":"(2011)","journal-title":"Neurobiol Aging"},{"key":"R96-20230909","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.21595","article-title":"Epigenetics and the nervous system","volume":"64","author":"Mehler","year":"(2008)","journal-title":"Ann Neurol"},{"key":"R97-20230909","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-genom-121520-081242","article-title":"Brain somatic mutation in aging and Alzheimer's disease","volume":"22","author":"Miller","year":"(2021)","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"R98-20230909","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41586-022-04640-1","article-title":"Somatic genomic changes in single Alzheimer's disease neurons","volume":"604","author":"Miller","year":"(2022)","journal-title":"Nature"},{"key":"R99-20230909","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/med.21622","article-title":"BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease","volume":"40","author":"Moussa-Pacha","year":"(2020)","journal-title":"Med Res Rev"},{"key":"R100-20230909","doi-asserted-by":"crossref","first-page":"031919","DOI":"10.1103\/PhysRevE.74.031919","article-title":"Tail-induced attraction between nucleosome core particles","volume":"74","author":"M\u00fchlbacher","year":"(2006)","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"R101-20230909","doi-asserted-by":"crossref","first-page":"878276","DOI":"10.3389\/fnagi.2022.878276","article-title":"Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease","volume":"14","author":"Mukerjee","year":"(2022)","journal-title":"Front Aging Neurosci"},{"key":"R102-20230909","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0892-345","article-title":"A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid","volume":"1","author":"Mullan","year":"(1992)","journal-title":"Nat Genet"},{"key":"R103-20230909","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(01)00721-1","article-title":"Epigenetics: interaction of DNA methylation and chromatin","volume":"278","author":"Nakao","year":"(2001)","journal-title":"Gene"},{"key":"R104-20230909","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.bbrc.2009.08.056","article-title":"Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer","volume":"388","author":"Namanja","year":"(2009)","journal-title":"Biochem Biophys Res Commun"},{"key":"R105-20230909","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/aje\/kwj267","article-title":"Curry consumption and cognitive function in the elderly","volume":"164","author":"Ng","year":"(2006)","journal-title":"Am J Epidemiol"},{"key":"R107-20230909","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"(1999)","journal-title":"Cell"},{"key":"R108-20230909","doi-asserted-by":"crossref","first-page":"eabc6184","DOI":"10.1126\/scitranslmed.abc6184","article-title":"The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid \u03b2fibril formation","volume":"13","author":"Pagnon de la Vega","year":"(2021)","journal-title":"Sci Transl Med"},{"key":"R109-20230909","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.toxlet.2009.10.010","article-title":"The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells","volume":"192","author":"Paluszczak","year":"(2010)","journal-title":"Toxicol Lett"},{"key":"R110-20230909","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.drudis.2006.10.013","article-title":"Blood\u2013brain barrier delivery","volume":"12","author":"Pardridge","year":"(2007)","journal-title":"Drug Discov Today"},{"key":"R111-20230909","doi-asserted-by":"crossref","first-page":"13954","DOI":"10.3390\/ijms232213954","article-title":"Alzheimer's disease: treatment strategies and their limitations","volume":"23","author":"Passeri","year":"(2022)","journal-title":"Int J Mol Sci"},{"key":"R112-20230909","article-title":"World Alzheimer Report 2015: the global impact of dementia: an analysis of prevalence, incidence cost and trends: Alzheimer's","author":"Prince","year":"(2015)","journal-title":"Disease International"},{"key":"R113-20230909","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","article-title":"Curcumin and health","volume":"21","author":"Pulido-Moran","year":"(2016)","journal-title":"Molecules"},{"issue":"Suppl 1","key":"R114-20230909","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1755-8794-8-S1-S5","article-title":"The role of epigenetics in personalized medicine: challenges and opportunities","volume":"8","author":"Rasool","year":"(2015)","journal-title":"BMC Med Genomics"},{"key":"R115-20230909","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jnr.23886","article-title":"Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain","volume":"95","author":"Ratnu","year":"(2017)","journal-title":"J Neurosci Res"},{"key":"R116-20230909","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12263-011-0222-1","article-title":"Epigenetic changes induced by curcumin and other natural compounds","volume":"6","author":"Reuter","year":"(2011)","journal-title":"Genes Nutr"},{"key":"R117-20230909","doi-asserted-by":"crossref","first-page":"45518","DOI":"10.1074\/jbc.M207435200","article-title":"An iron-responsive element type II in the 5\u2019-untranslated region of the Alzheimer's amyloid precursor protein transcript","volume":"277","author":"Rogers","year":"(2002)","journal-title":"Journal of Biological Chemistry"},{"key":"R118-20230909","doi-asserted-by":"crossref","first-page":"45518","DOI":"10.1074\/jbc.M207435200","article-title":"An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript","volume":"277","author":"Rogers","year":"(2002)","journal-title":"J Biol Chem"},{"key":"R119-20230909","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0958-1669(94)90091-4","article-title":"APOE is a major susceptibility gene for Alzheimer's disease","volume":"5","author":"Roses","year":"(1994)","journal-title":"Curr Opin Biotechnol"},{"key":"R120-20230909","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1474-4422(05)70198-8","article-title":"Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease","volume":"4","author":"Rovio","year":"(2005)","journal-title":"Lancet Neurol"},{"key":"R121-20230909","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/sj.cdd.4401769","article-title":"HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis","volume":"13","author":"Saha","year":"(2006)","journal-title":"Cell Death Differ"},{"key":"R122-20230909","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fgene.2020.00171","article-title":"DNA methylation biomarkers in aging and age-related diseases","volume":"11","author":"Salameh","year":"(2020)","journal-title":"Front Genet"},{"key":"R123-20230909","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3390\/ijms14023834","article-title":"Crosstalk between oxidative stress and SIRT1: Impact on the aging process","volume":"14","author":"Salminen","year":"(2013)","journal-title":"Int J Mol Sci"},{"key":"R124-20230909","first-page":"1","article-title":"Cardioprotective effects of exercise and curcumin supplementation against myocardial ischemia-reperfusion injury","author":"Sayevand","year":"(2022)","journal-title":"Sport Sci Health"},{"key":"R125-20230909","doi-asserted-by":"crossref","first-page":"102032","DOI":"10.1016\/j.gde.2023.102032","article-title":"Contributions of 3D chromatin structure to cell-type-specific gene regulation","volume":"79","author":"Schaeffer","year":"(2023)","journal-title":"Curr Opin Genet Dev"},{"key":"R126-20230909","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41576-019-0128-0","article-title":"Long-range enhancer\u2013promoter contacts in gene expression control","volume":"20","author":"Schoenfelder","year":"(2019)","journal-title":"Nat Rev Genet"},{"key":"R127-20230909","doi-asserted-by":"crossref","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"(2014)","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"R128-20230909","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1371\/journal.pgen.0030181","article-title":"Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters","volume":"3","author":"Shen","year":"(2007)","journal-title":"PLoS Genet"},{"key":"R129-20230909","doi-asserted-by":"crossref","first-page":"e1002862","DOI":"10.1371\/journal.pmed.1002862","article-title":"Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study","volume":"16","author":"Sommerlad","year":"(2019)","journal-title":"PLoS Med"},{"key":"R130-20230909","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nrneurol.2017.181","article-title":"Somatic mutations accumulate in ageing and diseased neurons","volume":"14","author":"Starling","year":"(2018)","journal-title":"Nat Rev Neurol"},{"key":"R131-20230909","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2015.06.009","article-title":"Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals","volume":"600","author":"Tannorella","year":"(2015)","journal-title":"Neurosci Lett"},{"key":"R132-20230909","doi-asserted-by":"crossref","first-page":"a006296","DOI":"10.1101\/cshperspect.a006296","article-title":"The genetics of Alzheimer disease","volume":"2","author":"Tanzi","year":"(2012)","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R133-20230909","doi-asserted-by":"crossref","first-page":"e13430","DOI":"10.1111\/obr.13430","article-title":"BACE1: More than just a \u03b2-secretase","volume":"23","author":"Taylor","year":"(2022)","journal-title":"Obes Rev"},{"key":"R134-20230909","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2015.02.045","article-title":"The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review","volume":"562","author":"Vahid","year":"(2015)","journal-title":"Gene"},{"key":"R135-20230909","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","article-title":"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE","volume":"286","author":"Vassar","year":"(1999)","journal-title":"Science"},{"key":"R136-20230909","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12263-008-0091-4","article-title":"The neuroprotective potential of flavonoids: a multiplicity of effects","volume":"3","author":"Vauzour","year":"(2008)","journal-title":"Genes Nutr"},{"key":"R137-20230909","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.3892\/mmr.2016.5052","article-title":"Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model","volume":"13","author":"Wang","year":"(2016)","journal-title":"Mol Med Rep"},{"key":"R138-20230909","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/jamaneurol.2014.2157","article-title":";Alzheimer's Disease Genetics Consortium. Rarity of the Alzheimer disease-protective APP A673T variant in the United States","volume":"72","author":"Wang","year":"(2015)","journal-title":"JAMA Neurol"},{"key":"R139-20230909","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1038\/s41598-022-05164-4","article-title":"Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3'-UTR variation","volume":"12","author":"Wang","year":"(2022)","journal-title":"Sci Rep"},{"key":"R140-20230909","doi-asserted-by":"crossref","first-page":"e2698","DOI":"10.1371\/journal.pone.0002698","article-title":"Age-specific epigenetic drift in late-onset Alzheimer's disease","volume":"3","author":"Wang","year":"(2008)","journal-title":"PLoS One"},{"key":"R141-20230909","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/alzrt107","article-title":"Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease","volume":"4","author":"Weggen","year":"(2012)","journal-title":"Alzheimers Res Ther"},{"key":"R142-20230909","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02736773","article-title":"Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient","volume":"6","author":"West","year":"(1995)","journal-title":"J Mol Neurosci"},{"key":"R143-20230909","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature19847","article-title":"Chromosome conformation elucidates regulatory relationships in developing human brain","volume":"538","author":"Won","year":"(2016)","journal-title":"Nature"},{"key":"R144-20230909","first-page":"119","article-title":"On the mechanism and inhibition of DNA cytosine methyltransferases","volume":"198","author":"Wu","year":"(1985)","journal-title":"Prog Clin Biol Res"},{"key":"R145-20230909","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/990107","article-title":"Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity","volume":"402","author":"Yan","year":"(1999)","journal-title":"Nature"},{"key":"R146-20230909","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds, plaques and reduces amyloid in vivo","volume":"280","author":"Yang","year":"(2005)","journal-title":"J Biol Chem"},{"key":"R147-20230909","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nm0103-3","article-title":"Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease","volume":"9","author":"Yang","year":"(2003)","journal-title":"Nat Med"},{"key":"R148-20230909","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40035-017-0089-1","article-title":"The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease","volume":"6","author":"Yang","year":"(2017)","journal-title":"Transl Neurodegener"},{"key":"R149-20230909","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1471-2377-14-105","article-title":"Probable novel PSEN2 Val214Leu mutation in Alzheimer's disease supported by structural prediction","volume":"14","author":"Youn","year":"(2014)","journal-title":"BMC Neurol"},{"key":"R150-20230909","doi-asserted-by":"crossref","first-page":"20190027","DOI":"10.1515\/jib-2019-0027","article-title":"Non-Coding RNAs and their Integrated Networks","volume":"16","author":"Zhang","year":"(2019)","journal-title":"J Integr Bioinform"},{"key":"R151-20230909","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.lfs.2018.09.002","article-title":"GAS5 promotes airway smooth muscle cell proliferation in asthma via controlling miR-10a\/BDNF signaling pathway","volume":"212","author":"Zhang","year":"(2018)","journal-title":"Life Sci"},{"key":"R152-20230909","doi-asserted-by":"crossref","first-page":"888","DOI":"10.4161\/epi.6.7.16315","article-title":"Genistein, an epigenome modifier during cancer prevention","volume":"6","author":"Zhang","year":"(2011)","journal-title":"Epigenetics"},{"key":"R153-20230909","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/NEN.0b013e318283114a","article-title":"Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model","volume":"72","author":"Zhang","year":"(2013)","journal-title":"J Neuropathol Exp Neurol"},{"key":"R154-20230909","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbadis.2008.10.014","article-title":"Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease","volume":"1792","author":"Zhao","year":"(2009)","journal-title":"Biochim Biophys Acta"},{"key":"R155-20230909","doi-asserted-by":"crossref","first-page":"8174345","DOI":"10.1155\/2018\/8174345","article-title":"Ginsenosides: A Potential Neuroprotective Agent","volume":"2018","author":"Zheng","year":"(2018)","journal-title":"Biomed Res Int"},{"key":"R156-20230909","doi-asserted-by":"crossref","first-page":"eabn9380","DOI":"10.1126\/scitranslmed.abn9380","article-title":"Synaptogenic effect of APP-Swedish mutation in familial Alzheimer's disease","volume":"14","author":"Zhou","year":"(2022)","journal-title":"Sci Transl Med"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.382232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:09Z","timestamp":1787166789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.382232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":154,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.382232","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]}}}