{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:22:18Z","timestamp":1793647338281,"version":"4.5.1"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>JOURNAL\/nrgr\/04.03\/01300535-202405000-00038\/inline-graphic1\/v\/2023-09-28T063346Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    We previously showed that hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice. However, the precise mechanism underlying the role of H\n                    <jats:sub>2<\/jats:sub>\n                    S in this situation remains unclear. In this study, we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine, a H\n                    <jats:sub>2<\/jats:sub>\n                    S precursor, attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionine \u03b2 synthase (a major H\n                    <jats:sub>2<\/jats:sub>\n                    S synthetase in the brain) in the prefrontal cortex. We also found that an miR-9-5p inhibitor blocked the expression of cystathionine \u03b2 synthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ischemia. Furthermore, miR-9-5p overexpression increased cystathionine-\u03b2-synthase and H\n                    <jats:sub>2<\/jats:sub>\n                    S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury. L-cysteine decreased the expression of CXCL11, an miR-9-5p target gene, in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3, FSTL1, SOCS2 and SOCS5, while treatment with an miR-9-5p inhibitor reversed these changes. These findings suggest that H\n                    <jats:sub>2<\/jats:sub>\n                    S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p\/CXCL11 axis and restoring \u03b2-synthase expression, thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.382860","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:00:24Z","timestamp":1695873624000},"page":"1084-1091","source":"Crossref","is-referenced-by-count":20,"title":["The miR-9-5p\/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury"],"prefix":"10.4103","volume":"19","author":[{"given":"Yijing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Qingdao Municipal Hospital, Qingdao, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zige","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Gai","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and Ethics, School of Basic Medicine Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqing","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-4874","authenticated-orcid":false,"given":"Dexiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and Ethics, School of Basic Medicine Sciences, Cheeloo College of Medicine, 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