{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:00:55Z","timestamp":1792101655660,"version":"4.4.0"},"reference-count":89,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202411000-00032\/figure1\/v\/2026-06-18T063637Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    High intraocular pressure causes retinal ganglion cell injury in primary and secondary glaucoma diseases, yet the molecular landscape characteristics of retinal cells under high intraocular pressure remain unknown. Rat models of acute hypertension ocular pressure were established by injection of cross-linked hyaluronic acid hydrogel (Healaflow\u00ae). Single-cell RNA sequencing was then used to describe the cellular composition and molecular profile of the retina following high intraocular pressure. Our results identified a total of 12 cell types, namely retinal pigment epithelial cells, rod-photoreceptor cells, bipolar cells, M\u00fcller cells, microglia, cone-photoreceptor cells, retinal ganglion cells, endothelial cells, retinal progenitor cells, oligodendrocytes, pericytes, and fibroblasts. The single-cell RNA sequencing analysis of the retina under acute high intraocular pressure revealed obvious changes in the proportions of various retinal cells, with ganglion cells decreased by 23%. Hematoxylin and eosin staining and TUNEL staining confirmed the damage to retinal ganglion cells under high intraocular pressure. We extracted data from retinal ganglion cells and analyzed the retinal ganglion cell cluster with the most distinct expression. We found upregulation of the\n                    <jats:italic toggle=\"yes\">B3gat2<\/jats:italic>\n                    gene, which is associated with neuronal migration and adhesion, and downregulation of the\n                    <jats:italic toggle=\"yes\">Tsc22d<\/jats:italic>\n                    gene, which participates in inhibition of inflammation. This study is the first to reveal molecular changes and intercellular interactions in the retina under high intraocular pressure. These data contribute to understanding of the molecular mechanism of retinal injury induced by high intraocular pressure and will benefit the development of novel therapies.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.389363","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:02:09Z","timestamp":1699434129000},"page":"2522-2531","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Single-cell RNA sequencing analysis of the retina under acute high intraocular pressure"],"prefix":"10.4103","volume":"19","author":[{"given":"Shaojun","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingxiu","family":"Dang","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sui","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-2583","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-8006","authenticated-orcid":false,"given":"Dajiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"R1-20260618","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"R2-20260618","article-title":"ARVO Statement for the Use of Animals in Ophthalmic and Vision Research","year":"2021"},{"key":"R3-20260618","doi-asserted-by":"crossref","first-page":"102199","DOI":"10.1016\/j.pneurobio.2021.102199","article-title":"Reactive astrocytes prevent maladaptive plasticity after ischemic stroke","volume":"209","author":"Aswendt","year":"2022","journal-title":"Prog Neurobiol"},{"key":"R4-20260618","doi-asserted-by":"crossref","first-page":"860070","DOI":"10.3389\/fimmu.2022.860070","article-title":"Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy","volume":"13","author":"Au","year":"2022","journal-title":"Front Immunol"},{"key":"R5-20260618","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.7150\/thno.48110","article-title":"Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes","volume":"11","author":"Barca","year":"2021","journal-title":"Theranostics"},{"key":"R6-20260618","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s40135-019-00212-1","article-title":"Immunomodulation as a neuroprotective strategy for glaucoma treatment","volume":"7","author":"Bari\u015f","year":"2019","journal-title":"Curr Ophthalmol Rep"},{"key":"R7-20260618","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","author":"Becht","year":"2018","journal-title":"Nat Biotechnol"},{"key":"R8-20260618","first-page":"605","article-title":"Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study","volume":"55","author":"B\u00fcchi","year":"1992","journal-title":"I. 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