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The circadian clock emerges as a key regulator, sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes, such as stem-cell function, cellular stress responses, and inter-tissue communication, which become disrupted during aging. Given the crucial role of hypothalamic circuits in regulating organismal physiology, metabolic control, sleep homeostasis, and circadian rhythms, and their dependence on these processes, strategies aimed at enhancing hypothalamic and circadian function, including pharmacological and non-pharmacological approaches, offer systemic benefits for healthy aging. Intranasal brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions, like the hypothalamus, while reducing side effects associated with systemic drug delivery, thereby presenting new therapeutic possibilities for diverse age-related conditions.<\/jats:p>","DOI":"10.4103\/1673-5374.389624","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:04:40Z","timestamp":1702544680000},"page":"1919-1928","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Hypothalamic circuits and aging: keeping the circadian clock updated"],"prefix":"10.4103","volume":"19","author":[{"given":"Rosa","family":"V\u00e1zquez-Lizarraga","sequence":"first","affiliation":[{"name":"Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), M\u00e9xico City, 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