{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:25:31Z","timestamp":1790288731308,"version":"4.1.0"},"reference-count":117,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Controlling intracranial pressure, nerve cell regeneration, and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury. There is currently a lack of effective treatment methods. Hibernation has the characteristics of low temperature, low metabolism, and hibernation rhythm, as well as protective effects on the nervous, cardiovascular, and motor systems. Artificial hibernation technology is a new technology that can effectively treat acute brain injury by altering the body's metabolism, lowering the body's core temperature, and allowing the body to enter a state similar to hibernation. This review introduces artificial hibernation technology, including mild hypothermia treatment technology, central nervous system regulation technology, and artificial hibernation-inducer technology. Upon summarizing the relevant research on artificial hibernation technology in acute brain injury, the research results show that artificial hibernation technology has neuroprotective, anti-inflammatory, and oxidative stress-resistance effects, indicating that it has therapeutic significance in acute brain injury. Furthermore, artificial hibernation technology can alleviate the damage of ischemic stroke, traumatic brain injury, cerebral hemorrhage, cerebral infarction, and other diseases, providing new strategies for treating acute brain injury. However, artificial hibernation technology is currently in its infancy and has some complications, such as electrolyte imbalance and coagulation disorders, which limit its use. Further research is needed for its clinical application.<\/jats:p>","DOI":"10.4103\/1673-5374.390968","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:08:33Z","timestamp":1702544913000},"page":"1940-1946","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Application of artificial hibernation technology in acute brain injury"],"prefix":"10.4103","volume":"19","author":[{"given":"Xiaoni","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulian","family":"Chen","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of People's Armed Police Forces, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of People's Armed Police Forces, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Song","sequence":"additional","affiliation":[{"name":"Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Niu","sequence":"additional","affiliation":[{"name":"Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4861-5412","authenticated-orcid":false,"given":"Xiaochu","family":"Chen","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of People's Armed Police Forces, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-8349","authenticated-orcid":false,"given":"Xuyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of People's Armed Police Forces, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"R1-20260525","doi-asserted-by":"crossref","first-page":"011001","DOI":"10.1088\/1741-2552\/aaf12e","article-title":"A comprehensive review of EEG-based brain-computer interface paradigms","volume":"16","author":"Abiri","year":"2019","journal-title":"J Neural Eng"},{"key":"R2-20260525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta22450","article-title":"Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT","volume":"22","author":"Andrews","year":"2018","journal-title":"Health Technol Assess"},{"key":"R3-20260525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00360-019-01255-3","article-title":"Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis","volume":"190","author":"Arfat","year":"2020","journal-title":"J Comp Physiol B"},{"key":"R4-20260525","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physrev.00009.2017","article-title":"Chemogenetic tools for causal cellular and neuronal biology","volume":"98","author":"Atasoy","year":"2018","journal-title":"Physiol Rev"},{"key":"R5-20260525","doi-asserted-by":"crossref","first-page":"R301","DOI":"10.1152\/ajpregu.00314.2016","article-title":"Enhanced oxidative capacity of ground squirrel brain mitochondria during hibernation","volume":"312","author":"Ballinger","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R6-20260525","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/CCM.0b013e318194abf2","article-title":"Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children","volume":"37","author":"Bayir","year":"2009","journal-title":"Crit Care Med"},{"key":"R7-20260525","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"R8-20260525","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00360-018-1186-x","article-title":"Cardiovascular resistance to thrombosis in 13-lined ground squirrels","volume":"189","author":"Bonis","year":"2019","journal-title":"J Comp Physiol B"},{"key":"R9-20260525","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s11064-022-03824-5","article-title":"Therapeutic hypothermia combined with hydrogen sulfide treatment attenuated early blood-brain barrier disruption and brain edema induced by cardiac arrest and resuscitation in rat model","volume":"48","author":"Cai","year":"2023","journal-title":"Neurochem Res"},{"key":"R10-20260525","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/physrev.00008.2003","article-title":"Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature","volume":"83","author":"Carey","year":"2003","journal-title":"Physiol Rev"},{"key":"R11-20260525","first-page":"385","article-title":"Chinese consensus for mild hypothermia brain protection","volume":"32","year":"2020","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"R12-20260525","doi-asserted-by":"crossref","first-page":"160002","DOI":"10.1098\/rsos.160002","article-title":"Decreases in body temperature and body mass constitute pre-hibernation remodelling in the Syrian golden hamster, a facultative mammalian hibernator","volume":"3","author":"Chayama","year":"2016","journal-title":"R Soc Open Sci"},{"key":"R13-20260525","first-page":"CD010904","article-title":"Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury","volume":"1","author":"Chen","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"R14-20260525","first-page":"1515","article-title":"Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats","volume":"18","author":"Chen","year":"2019","journal-title":"Exp Ther Med"},{"key":"R15-20260525","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainresbull.2017.01.003","article-title":"Early stage alterations of catecholamine and adrenocorticotropic hormone levels in posttraumatic acute diffuse brain swelling","volume":"130","author":"Chen","year":"2017","journal-title":"Brain Res Bull"},{"key":"R16-20260525","doi-asserted-by":"crossref","first-page":"e7587","DOI":"10.7717\/peerj.7587","article-title":"The heart of a hibernator: EGFR and MAPK signaling in cardiac muscle during the hibernation of thirteen-lined ground squirrels, Ictidomys tridecemlineatus","volume":"7","author":"Childers","year":"2019","journal-title":"Peerj"},{"key":"R17-20260525","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3346\/jkms.2017.32.8.1337","article-title":"Feasibility and safety of mild therapeutic hypothermia in poor-grade subarachnoid hemorrhage: prospective pilot study","volume":"32","author":"Choi","year":"2017","journal-title":"J Korean Med Sci"},{"key":"R18-20260525","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3390\/cells11071110","article-title":"The DREADDful hurdles and opportunities of the chronic chemogenetic toolbox","volume":"11","author":"Claes","year":"2022","journal-title":"Cells"},{"key":"R19-20260525","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbi.2017.10.009","article-title":"Brain inflammatory cytokines and microglia morphology changes throughout hibernation phases in Syrian hamster","volume":"68","author":"Cogut","year":"2018","journal-title":"Brain Behav Immun"},{"key":"R20-20260525","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3390\/ijms22020707","article-title":"Perinatal infection: a major contributor to efficacy of cooling in newborns following birth asphyxia","volume":"22","author":"Danladi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R21-20260525","doi-asserted-by":"crossref","first-page":"e4698","DOI":"10.7717\/peerj.4698","article-title":"Seasonal migrations, body temperature fluctuations, and infection dynamics in adult amphibians","volume":"6","author":"Daversa","year":"2018","journal-title":"PeerJ"},{"key":"R22-20260525","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.163.3864.298","article-title":"Hibernation induced in ground squirrels by blood transfusion","volume":"163","author":"Dawe","year":"1969","journal-title":"Science"},{"key":"R23-20260525","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/STROKEAHA.119.026523","article-title":"New endovascular approach for hypothermia with intrajugular cooling and neuroprotective effect in ischemic stroke","volume":"51","author":"Duan","year":"2020","journal-title":"Stroke"},{"key":"R24-20260525","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/TA.0000000000001522","article-title":"Optimization of brain metabolism using metabolic-targeted therapeutic hypothermia can reduce mortality from traumatic brain injury","volume":"83","author":"Feng","year":"2017","journal-title":"J Trauma Acute Care Surg"},{"key":"R25-20260525","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/1673-5374.317959","article-title":"Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity","volume":"17","author":"Ferrari","year":"2022","journal-title":"Neural Regen Res"},{"key":"R26-20260525","doi-asserted-by":"crossref","first-page":"13000","DOI":"10.3390\/ijms232113000","article-title":"Oxidative stress in traumatic brain injury","volume":"23","author":"Fesharaki-Zadeh","year":"2022","journal-title":"Int J Mol Sci"},{"key":"R27-20260525","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2008.04.020","article-title":"Long-term hypothermia reduces infarct volume in aged rats after focal ischemia","volume":"438","author":"Florian","year":"2008","journal-title":"Neurosci Lett"},{"key":"R28-20260525","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pneurobio.2016.03.002","article-title":"Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction","volume":"157","author":"Forreider","year":"2017","journal-title":"Prog Neurobiol"},{"key":"R29-20260525","doi-asserted-by":"crossref","first-page":"111054","DOI":"10.1016\/j.mce.2020.111054","article-title":"Thermoregulation in hibernating mammals: The role of the \u201cthyroid hormones system.\u201d","volume":"519","author":"Frare","year":"2021","journal-title":"Mol Cell Endocrinol"},{"key":"R30-20260525","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1016\/j.cub.2013.01.062","article-title":"Hibernation","volume":"23","author":"Geiser","year":"2013","journal-title":"Curr Biol"},{"key":"R31-20260525","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.aan2475","article-title":"Chemogenetics revealed: DREADD occupancy and activation via converted clozapine","volume":"357","author":"Gomez","year":"2017","journal-title":"Science"},{"key":"R32-20260525","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00360-015-0905-9","article-title":"Proteomics approaches shed new light on hibernation physiology","volume":"185","author":"Grabek","year":"2015","journal-title":"J Comp Physiol B"},{"key":"R33-20260525","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1007\/s12035-021-02542-3","article-title":"Phenothiazine inhibits neuroinflammation and inflammasome activation independent of hypothermia after ischemic stroke","volume":"58","author":"Guo","year":"2021","journal-title":"Mol Neurobiol"},{"key":"R34-20260525","doi-asserted-by":"crossref","first-page":"8704352","DOI":"10.1155\/2017\/8704352","article-title":"Therapeutic hypothermia reduces oxidative damage and alters antioxidant defenses after cardiac arrest","volume":"2017","author":"Hackenhaar","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"R35-20260525","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijmm.2021.5060","article-title":"BAY61-3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle\/Syk signaling response after traumatic brain injury","volume":"49","author":"He","year":"2022","journal-title":"Int J Mol Med"},{"key":"R36-20260525","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-020-2387-5","article-title":"Neurons that regulate mouse torpor","volume":"583","author":"Hrvatin","year":"2020","journal-title":"Nature"},{"key":"R37-20260525","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.3390\/jcm12062095","article-title":"Brain hypothermia therapy and targeted temperature management for acute encephalopathy in children: status and prospects","volume":"12","author":"Imataka","year":"2023","journal-title":"J Clin Med"},{"key":"R38-20260525","doi-asserted-by":"crossref","first-page":"631258","DOI":"10.3389\/fped.2021.631258","article-title":"Pathophysiology of cerebral hyperperfusion in term neonates with hypoxic-ischemic encephalopathy: a systematic review for future research","volume":"9","author":"Kleuskens","year":"2021","journal-title":"Front Pediatr"},{"key":"R39-20260525","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1227\/neu.0000000000002122","article-title":"Targeted temperature management for severe subarachnoid hemorrhage using endovascular and surface cooling systems: a nonrandomized interventional study using historical control","volume":"91","author":"Kobata","year":"2022","journal-title":"Neurosurgery"},{"key":"R40-20260525","first-page":"1467","article-title":"Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats","volume":"69","author":"Kuo","year":"2010","journal-title":"J Trauma"},{"key":"R41-20260525","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.2174\/0929867326666190506124836","article-title":"Therapeutic hypothermia and neuroprotection in acute neurological disease","volume":"26","author":"Kurisu","year":"2019","journal-title":"Curr Med Chem"},{"key":"R42-20260525","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1001\/jama.2017.14972","article-title":"Effect of therapeutic hypothermia initiated after 6 hours of age on death or disability among newborns with hypoxic-ischemic encephalopathy: a randomized clinical trial","volume":"318","author":"Laptook","year":"2017","journal-title":"JAMA"},{"key":"R43-20260525","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.nbd.2016.09.013","article-title":"Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice","volume":"96","author":"Lee","year":"2016","journal-title":"Neurobiol Dis"},{"key":"R44-20260525","first-page":"CD001048","article-title":"Hypothermia for traumatic brain injury","volume":"9","author":"Lewis","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"R45-20260525","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0963689718819443","article-title":"Therapeutic target and cell-signal communication of chlorpromazine and promethazine in attenuating blood-brain barrier disruption after ischemic stroke","volume":"28","author":"Li","year":"2019","journal-title":"Cell Transplant"},{"key":"R46-20260525","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/01.PCC.0000298639.08519.0C","article-title":"Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated piglets","volume":"9","author":"Li","year":"2008","journal-title":"Pediatr Crit Care Med"},{"key":"R47-20260525","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/glia.21033","article-title":"Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic","volume":"58","author":"Li","year":"2010","journal-title":"Glia"},{"key":"R48-20260525","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2011.12.053","article-title":"Cold-inducible RNA binding protein inhibits H\u2082O\u2082-induced apoptosis in rat cortical neurons","author":"Li","year":"2012","journal-title":"Brain Res"},{"key":"R49-20260525","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.4103\/1673-5374.371366","article-title":"Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen Res"},{"key":"R50-20260525","doi-asserted-by":"crossref","first-page":"73613","DOI":"10.18632\/oncotarget.20280","article-title":"5-HT1a activation in PO\/AH area induces therapeutic hypothermia in a rat model of intracerebral hemorrhage","volume":"8","author":"Liang","year":"2017","journal-title":"Oncotarget"},{"key":"R51-20260525","doi-asserted-by":"crossref","first-page":"9176","DOI":"10.1111\/jcmm.15555","article-title":"The overexpression of RBM3 alleviates TBI-induced behaviour impairment and AD-like tauopathy in mice","volume":"24","author":"Liu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"R52-20260525","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/cns.13061","article-title":"Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice","volume":"24","author":"Liu","year":"2018","journal-title":"CNS Neurosci Ther"},{"key":"R53-20260525","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.4103\/1673-5374.282242","article-title":"Regrowth and neuronal protection are key for mammalian hibernation: roles for metabolic suppression","volume":"15","author":"Logan","year":"2020","journal-title":"Neural Regen Res"},{"key":"R54-20260525","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3390\/bios12121167","article-title":"A review: research progress of neural probes for brain research and brain-computer interface","volume":"12","author":"Luo","year":"2022","journal-title":"Biosensors (Basel)"},{"key":"R55-20260525","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0140-6736(17)30547-0","article-title":"Towards evidence-based resuscitation of the newborn infant","volume":"389","author":"Manley","year":"2017","journal-title":"Lancet"},{"key":"R56-20260525","doi-asserted-by":"crossref","first-page":"520745","DOI":"10.1155\/2015\/520745","article-title":"5'-adenosine monophosphate-induced hypothermia attenuates brain ischemia\/reperfusion injury in a rat model by inhibiting the inflammatory response","volume":"2015","author":"Miao","year":"2015","journal-title":"Mediat Inflamm"},{"key":"R57-20260525","doi-asserted-by":"crossref","first-page":"19723","DOI":"10.1038\/s41598-022-24251-0","article-title":"Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation","volume":"12","author":"Miyazaki","year":"2022","journal-title":"Sci Rep"},{"key":"R58-20260525","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-cellbio-012820-095945","article-title":"Cellular, molecular, and physiological adaptations of hibernation: the solution to environmental challenges","volume":"36","author":"Mohr","year":"2020","journal-title":"Annu Rev Cell Dev Bi"},{"key":"R59-20260525","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/acschemneuro.3c00268","article-title":"Peptidomic analysis reveals seasonal neuropeptide and peptide hormone changes in the hypothalamus and pituitary of a hibernating mammal","volume":"14","author":"Mousavi","year":"2023","journal-title":"ACS Chem Neurosci"},{"key":"R60-20260525","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/s120201211","article-title":"Brain computer interfaces, a review","volume":"12","author":"Nicolas-Alonso","year":"2012","journal-title":"Sensors (Basel)"},{"key":"R61-20260525","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1089\/neu.2018.5649","article-title":"Therapeutic whole-body hypothermia reduces death in severe traumatic brain injury if the cooling index is sufficiently high: meta-analyses of the effect of single cooling parameters and their integrated measure","volume":"35","author":"Olah","year":"2018","journal-title":"J Neurotraum"},{"key":"R62-20260525","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3390\/ph14100992","article-title":"The hypothermic effect of hydrogen sulfide is mediated by the transient receptor potential ankyrin-1 channel in mice","volume":"14","author":"Olah","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"R63-20260525","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMc1600339","article-title":"Hypothermia for intracranial hypertension after traumatic brain injury","volume":"374","author":"O'Leary","year":"2016","journal-title":"N Engl J Med"},{"key":"R64-20260525","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2018.11.059","article-title":"Turning down the heat: Down-regulation of sarcolipin in a hibernating mammal","volume":"696","author":"Oliver","year":"2019","journal-title":"Neurosci Lett"},{"key":"R65-20260525","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.devcel.2021.02.024","article-title":"Lipid metabolism in adaptation to extreme nutritional challenges","volume":"56","author":"Olsen","year":"2021","journal-title":"Dev Cell"},{"key":"R66-20260525","doi-asserted-by":"crossref","first-page":"296","DOI":"10.5492\/wjccm.v4.i4.296","article-title":"Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury","volume":"4","author":"O'Phelan","year":"2015","journal-title":"World J Crit Care Med"},{"key":"R67-20260525","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3390\/bioengineering9120768","article-title":"A review of brain activity and EEG-based brain-computer interfaces for rehabilitation application","volume":"9","author":"Orban","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"R68-20260525","doi-asserted-by":"crossref","first-page":"bio058567","DOI":"10.1242\/bio.058567","article-title":"Variations in oxidative stress and antioxidant defense level during different phases of hibernation in common Asian toad, Duttaphrynus melanostictus","volume":"10","author":"Patnaik","year":"2021","journal-title":"Biol Open"},{"key":"R69-20260525","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature14142","article-title":"RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration","volume":"518","author":"Peretti","year":"2015","journal-title":"Nature"},{"key":"R70-20260525","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0140-6736(08)60837-5","article-title":"Induced hypothermia and fever control for prevention and treatment of neurological injuries","volume":"371","author":"Polderman","year":"2008","journal-title":"Lancet"},{"key":"R71-20260525","doi-asserted-by":"crossref","first-page":"e17157","DOI":"10.15252\/emmm.202217157","article-title":"ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo","volume":"15","author":"Preu\u00dfner","year":"2023","journal-title":"EMBO Mol Med"},{"key":"R72-20260525","doi-asserted-by":"crossref","first-page":"16405","DOI":"10.1038\/s41598-022-20382-6","article-title":"Synthetic torpor protects rats from exposure to accelerated heavy ions","volume":"12","author":"Puspitasari","year":"2022","journal-title":"Sci Rep"},{"key":"R73-20260525","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-023-00424-7","article-title":"Intracerebral haemorrhage","volume":"9","author":"Puy","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"R74-20260525","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neucom.2016.10.024","article-title":"Brain computer interface: control signals review","volume":"223","author":"Ramadan","year":"2017","journal-title":"Neurocomputing"},{"key":"R75-20260525","doi-asserted-by":"crossref","first-page":"32136","DOI":"10.1073\/pnas.1922888117","article-title":"Seasonal plasticity in the adult somatosensory cortex","volume":"117","author":"Ray","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R76-20260525","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.4103\/1673-5374.335824","article-title":"Status of precision medicine approaches to traumatic brain injury","volume":"17","author":"Reddi","year":"2022","journal-title":"Neural Regen Res"},{"key":"R77-20260525","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/1749-4877.12504","article-title":"Phenotypic changes in the metabolic profile and adiponectin activity during seasonal fattening and hibernation in female Daurian ground squirrels (Spermophilus dauricus)","volume":"17","author":"Ren","year":"2022","journal-title":"Integr Zool"},{"key":"R78-20260525","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1086\/679591","article-title":"Thermogenic capacity at subzero temperatures: how low can a hibernator go?","volume":"88","author":"Richter","year":"2015","journal-title":"Physiol Biochem Zool"},{"key":"R79-20260525","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"key":"R80-20260525","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature12808","article-title":"Transcranial amelioration of inflammation and cell death after brain injury","volume":"505","author":"Roth","year":"2014","journal-title":"Nature"},{"key":"R81-20260525","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1056\/NEJM200107053450114","article-title":"Lack of effect of induction of hypothermia after acute brain injury","volume":"345","author":"Safar","year":"2001","journal-title":"N Engl J Med"},{"key":"R82-20260525","first-page":"401","article-title":"Post-stroke gaseous hypothermia increases vascular density but not neurogenesis in the ischemic penumbra of aged rats","volume":"34","author":"Sandu","year":"2016","journal-title":"Restor Neurol Neuros"},{"key":"R83-20260525","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2174\/1570159X16666180412110919","article-title":"Inflammatory events following subarachnoid hemorrhage (SAH)","volume":"16","author":"Schneider","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"R84-20260525","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1590\/1980-57642018dn12-040012","article-title":"Impacts of cognitive impairment for different levels and causes of traumatic brain injury, and education status in TBI patients","volume":"12","author":"Sharbafshaaer","year":"2018","journal-title":"Dement Neuropsychol"},{"key":"R85-20260525","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/brv.12671","article-title":"Human torpor: translating insights from nature into manned deep space expedition","volume":"96","author":"Shi","year":"2021","journal-title":"Biol Rev Camb Philos Soc"},{"key":"R86-20260525","first-page":"50","article-title":"A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure","volume":"94","author":"Shiozaki","year":"2001","journal-title":"Mild Hypothermia Study Group in Japan. J Neurosurg"},{"key":"R87-20260525","doi-asserted-by":"crossref","first-page":"e55578","DOI":"10.7554\/eLife.55578","article-title":"Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells","volume":"9","author":"Singhal","year":"2020","journal-title":"Elife"},{"key":"R88-20260525","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/j.2040-4603.2016.tb00689.x","article-title":"Metabolic flexibility: hibernation, torpor, and estivation","volume":"6","author":"Staples","year":"2016","journal-title":"Compr Physiol"},{"key":"R89-20260525","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1152\/japplphysiol.01598.2011","article-title":"Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats","volume":"112","author":"Stein","year":"2012","journal-title":"J Appl Physiol. (1985)"},{"key":"R90-20260525","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13054-016-1318-1","article-title":"Chronic impact of traumatic brain injury on outcome and quality of life: a narrative review","volume":"20","author":"Stocchetti","year":"2016","journal-title":"Crit Care"},{"key":"R91-20260525","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0065-2423(10)52003-1","article-title":"Metabolic rate depression: the biochemistry of mammalian hibernation","volume":"52","author":"Storey","year":"2010","journal-title":"Adv Clin Chem"},{"key":"R92-20260525","first-page":"101","article-title":"Effect of local mild hypothermia on regional cerebral blood flow in patients with acute intracerebral hemorrhage assessed by 99mTc-ECD SPECT imaging","volume":"23","author":"Su","year":"2015","journal-title":"J X-ray Sci Technol"},{"key":"R93-20260525","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/neu.2014.3584","article-title":"Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the computed tomography classification of the traumatic coma data bank","volume":"32","author":"Suehiro","year":"2015","journal-title":"J Neurotraum"},{"key":"R94-20260525","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fnins.2019.00586","article-title":"Neuroprotection by therapeutic hypothermia","volume":"13","author":"Sun","year":"2019","journal-title":"Front Neurosci"},{"key":"R95-20260525","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/cbf.3422","article-title":"Identification of a prosurvival neuroprotective mitochondrial peptide in a mammalian hibernator","volume":"37","author":"Szereszewski","year":"2019","journal-title":"Cell Biochem Funct"},{"key":"R96-20260525","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-020-2163-6","article-title":"A discrete neuronal circuit induces a hibernation-like state in rodents","volume":"583","author":"Takahashi","year":"2020","journal-title":"Nature"},{"key":"R97-20260525","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1177\/0271678X16680003","article-title":"Posttraumatic therapeutic hypothermia alters microglial and macrophage polarization toward a beneficial phenotype","volume":"37","author":"Truettner","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"R98-20260525","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-pharmtox-010814-124803","article-title":"DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility","volume":"55","author":"Urban","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R99-20260525","doi-asserted-by":"crossref","first-page":"10590","DOI":"10.1523\/JNEUROSCI.2874-06.2006","article-title":"Ubiquitous and temperature-dependent neural plasticity in hibernators","volume":"26","author":"von der Ohe","year":"2006","journal-title":"J Neurosci"},{"key":"R100-20260525","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol Rev"},{"key":"R101-20260525","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1097\/CCM.0000000000003125","article-title":"Revisited: a systematic review of therapeutic hypothermia for adult patients following traumatic brain injury","volume":"46","author":"Watson","year":"2018","journal-title":"Crit Care Med"},{"key":"R102-20260525","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3389\/fphys.2019.01449","article-title":"Remarkable protective effects of Nrf2-mediated antioxidant enzymes and tissue specificity in different skeletal muscles of daurian ground squirrels over the torpor-arousal cycle","volume":"10","author":"Wei","year":"2019","journal-title":"Front Physiol"},{"key":"R103-20260525","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/SHK.0000000000001094","article-title":"Hibernation-based approaches in the treatment of hemorrhagic shock","volume":"50","author":"Wolf","year":"2018","journal-title":"Shock"},{"key":"R104-20260525","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00424-020-02511-0","article-title":"Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators","volume":"473","author":"Xie","year":"2021","journal-title":"Pflugers Arch"},{"key":"R105-20260525","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2015.01.047","article-title":"VAP-1 blockade prevents subarachnoid hemorrhage-associated cerebrovascular dilating dysfunction via repression of a neutrophil recruitment-related mechanism","author":"Xu","year":"2015","journal-title":"Brain Res"},{"key":"R106-20260525","doi-asserted-by":"crossref","first-page":"e2686","DOI":"10.1002\/brb3.2686","article-title":"Neuroprotective effects of mild hypothermia against traumatic brain injury by the involvement of the Nrf2\/ARE pathway","volume":"12","author":"Yan","year":"2022","journal-title":"Brain Behav"},{"key":"R107-20260525","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1161\/STROKEAHA.108.514471","article-title":"Metabolic downregulation: a key to successful neuroprotection?","volume":"39","author":"Yenari","year":"2008","journal-title":"Stroke"},{"key":"R108-20260525","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia","volume":"13","author":"Yenari","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"R109-20260525","doi-asserted-by":"crossref","first-page":"e0152135","DOI":"10.1371\/journal.pone.0152135","article-title":"Antioxidant defenses in the brains of bats during hibernation","volume":"11","author":"Yin","year":"2016","journal-title":"PLoS One"},{"key":"R110-20260525","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12974-018-1315-1","article-title":"Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy\/apoptosis and the MyD88-dependent TLR4 signaling pathway","volume":"15","author":"Zhang","year":"2018","journal-title":"J Neuroinflamm"},{"key":"R111-20260525","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.brainres.2015.07.004","article-title":"Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis","author":"Zhang","year":"2015","journal-title":"Brain Res"},{"key":"R112-20260525","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/cells9010042","article-title":"Priority strategy of intracellular Ca2+ homeostasis in skeletal muscle fibers during the multiple stresses of hibernation","volume":"9","author":"Zhang","year":"2019","journal-title":"Cells"},{"key":"R113-20260525","doi-asserted-by":"crossref","first-page":"115826","DOI":"10.1016\/j.bone.2020.115826","article-title":"A temporal study on musculoskeletal morphology and metabolism in hibernating Daurian ground squirrels (Spermophilus dauricus)","volume":"144","author":"Zhang","year":"2021","journal-title":"Bone"},{"key":"R114-20260525","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainresbull.2021.05.014","article-title":"Mild therapeutic hypothermia improves neurological outcomes in a rat model of cardiac arrest","volume":"173","author":"Zhang","year":"2021","journal-title":"Brain Res Bull"},{"key":"R115-20260525","doi-asserted-by":"crossref","first-page":"6890","DOI":"10.1038\/s41467-022-34735-2","article-title":"Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"key":"R116-20260525","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)","volume":"49","author":"Zhao","year":"2022","journal-title":"Int J Mol Med"},{"key":"R117-20260525","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0002-9440(10)64686-X","article-title":"Hibernation, a model of neuroprotection","volume":"158","author":"Zhou","year":"2001","journal-title":"Am J Pathol"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.390968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:55:47Z","timestamp":1786647347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1673-5374.390968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":117,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/1673-5374.390968","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"assertion":[{"value":"2023-06-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}