{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:55:01Z","timestamp":1793372101637,"version":"4.5.0"},"reference-count":83,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    The intricacies of Alzheimer\u2019s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms, particularly DNA methylation. This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer\u2019s disease neuropathology. The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer\u2019s disease progression. The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus. Notably,\n                    <jats:italic toggle=\"yes\">ANK1<\/jats:italic>\n                    hypermethylation, a protein implicated in neurofibrillary tangle formation, was recurrently identified in the entorhinal cortex. Further, the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like\n                    <jats:italic toggle=\"yes\">HOXA3<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">RHBDF2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">MCF2L<\/jats:italic>\n                    , potentially influencing neuroinflammatory processes. The complex role of\n                    <jats:italic toggle=\"yes\">BIN1<\/jats:italic>\n                    in late-onset Alzheimer\u2019s disease is underscored by its association with altered methylation patterns. Despite the disparities across studies, these findings highlight the intricate interplay between epigenetic modifications and Alzheimer\u2019s disease pathology. Future research efforts should address methodological variations, incorporate diverse cohorts, and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer\u2019s disease progression.\n                  <\/jats:p>","DOI":"10.4103\/1673-5374.393106","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:00:44Z","timestamp":1704794444000},"page":"2365-2376","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Unveiling DNA methylation in Alzheimer\u2019s disease: a review of array-based human brain studies"],"prefix":"10.4103","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-0165","authenticated-orcid":false,"given":"Victoria Cunha","family":"Alves","sequence":"first","affiliation":[{"name":"Neurodegenerative Diseases Group, Hospital Universitario 12 de Octubre Research Institute (imas12), Madrid, Spain"},{"name":"Network Center for Biomedical Research, Neurodegenerative Diseases (CIBERNED), Madrid, Spain"},{"name":"PhD Program in Neuroscience, Autonoma de Madrid University, Madrid, Spain"},{"name":"Neurotraumatology and Subarachnoid Hemorrhage Group, Hospital Universitario 12 de Octubre Research Institute (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Carro","sequence":"additional","affiliation":[{"name":"Network Center for Biomedical Research, Neurodegenerative Diseases (CIBERNED), Madrid, Spain"},{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research Into Chronic Diseases, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-1784","authenticated-orcid":false,"given":"Joana","family":"Figueiro-Silva","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, University of Zurich, Zurich, Switzerland"},{"name":"Department of Molecular Life Science, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"R1-20260618","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.3390\/nu13113979","article-title":"Targeting DNA methylation in the adult brain through diet","volume":"13","author":"Allison","year":"2021","journal-title":"Nutrients"},{"key":"R2-20260618","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.3390\/ijms21186570","article-title":"iRhom2: an emerging adaptor regulating immunity and disease","volume":"21","author":"Al-Salihi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R3-20260618","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13148-019-0672-7","article-title":"DNA methylation signature of human hippocampus in Alzheimer\u2019s disease is linked to 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