{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:40Z","timestamp":1787840560182,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n Background:<\/jats:title>\n Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases. The peeling method has been recently found to be effective for acne treatment. This study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n In a prospective single-blinded clinical trial, 86 patients with acne were randomly assigned into two groups. In both groups, the routine treatment of acne (topical solution of erythromycin 4%, triclorocarban soap, and sunscreen) were used twice a day for 8 weeks. In addition, salicylic acid 30% for the control group and pyruvic acid 50% for the case group were used. In both groups, acne severity index (ASI) was calculated before and at week 2, 4, 6, and 8 of the treatment. Patient satisfaction was assessed at the end of the treatment. Side effects were recorded using a checklist.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In both groups, the reduction in the number of comedones, papules, and ASI were statistically significant (\n P<\/jats:italic>\n < 0.001) in the course of treatment. However, it was not significant regarding the number of pustules (\n P<\/jats:italic>\n = 0.09). None of the number of comedone, papules, pustules, and ASI was statistically different between study groups. Both treatment groups had similar side effects except for scaling in the fifth session, which was significantly lower in salicylic acid \u2013 treated patients (\n P<\/jats:italic>\n = 0.015).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Both pyruvic acid 50% and salicylic acid 30% are effective in the improvement of mild to moderate acne with no significant difference in efficacy and side effects.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/1735-1995.181991","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T00:08:16Z","timestamp":1470355696000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Comparison the effectiveness of pyruvic acid 50% and salicylic acid 30% in the treatment of acne"],"prefix":"10.4103","volume":"21","author":[{"given":"Fariba","family":"Jaffary","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Saraeian","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Mohsen","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Skin Diseases and Leishmaniasis Research Center, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"R1-20250827","first-page":"161","article-title":"Incidence of acne vulgaris in the schools of Sari, Iran during 2003-2004","volume":"55","author":"Golpour","year":"2006","journal-title":"J Mazandaran Univ Med Sci"},{"key":"R2-20250827","first-page":"11","article-title":"Acne vulgaris: A comparison of therapeutic effects of zinc sulfate vs.tetracycline","volume":"39","author":"Rad","year":"2006","journal-title":"SJKU"},{"key":"R3-20250827","first-page":"24","article-title":"Efcacy of superfcial peeling with 70% glycolic acid in treatment of acne","volume":"24","author":"Nazemi","year":"2003","journal-title":"Iran J Dermatol"},{"key":"R4-20250827","first-page":"154","article-title":"The effect of cyproterone acetate lotion on acne","volume":"4","author":"Iraji","year":"2000","journal-title":"J Res Med 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pyruvic acid peel","volume":"32","author":"Berardesca","year":"2006","journal-title":"Dermatol Surg"},{"key":"R14-20250827","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1468-3083.2004.00759.x","article-title":"The use of pyruvic acid in the treatment of acne","volume":"18","author":"Cotellessa","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R15-20250827","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaad.2003.10.049","article-title":"The use of pyruvic acid in the treatment of acne","volume":"50","author":"Pacifco","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"R16-20250827","first-page":"7","article-title":"Pyruvic acid as a new therapeutic peeling agent in acne, melasma and warts","volume":"2","author":"Tosson","year":"2006","journal-title":"Egypt Dermatol Online J"},{"key":"R17-20250827","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jocd.12050","article-title":"Comparative study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris","volume":"13","author":"Marczyk","year":"2014","journal-title":"J Cosmet Dermatol"}],"container-title":["Journal of Research in Medical 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