{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:23:33Z","timestamp":1791897813040,"version":"4.3.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In the past several years, randomized controlled trials (RCTs) have indicated that inhaled nitric oxide (iNO) can potentially lower for both the incidence of bronchopulmonary dysplasia (BPD) and mortality in affected infants. Other research has, however, disagreed with these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We performed an updated meta analysis of all relevant RCTs to assess the benefits of iNO in preterm infants by searching PubMed, EMBASE, Cochrane databases, Wanfang, VIP, and CNKI databases for English and Chinese references.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ultimately, 22 RCTs were incorporated. (1) Risk of BPD was significantly lower in preterm infants supplemented with iNO (relative risk [RR] = 0.88;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0007). There are no differences concerning pulmonary hemorrhage (PH) (RR = 0.94;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.72). (2) Incidences of necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), and severe intracranial hemorrhage (ICH) were compared. No significant difference was discovered concerning these risks (RR = 1.21,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.08; RR = 1.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.89; and RR = 0.99,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.86). (3) In addition, no significant differences were found between experimental and control groups with respect to morality. (RR = 1.00,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.98).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our meta analysis has shown a beneficial effect in BPD and morality. In addition, our meta analysis suggests that iNO therapy does not increase the risk of common complications, such as NEC and ROP, and that it may also have no adverse effect on bleeding tendency diseases (severe ICH and PH).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1735-1995.183990","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T05:01:03Z","timestamp":1465880463000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Inhaled nitric oxide in preterm infants: An updated meta-analysis"],"prefix":"10.4103","volume":"21","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neonates, Nanjing Children's Hospital of Nanjing Medical University, Nanjing 210008, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neonates, Nanjing Children's Hospital of Nanjing Medical University, Nanjing 210008, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Guang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonates, Nanjing Children's Hospital of Nanjing Medical University, Nanjing 210008, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jiangsu Provincial Hospital of Nanjing Medical University, Nanjing 210029, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonates, Nanjing Children's Hospital of Nanjing Medical University, Nanjing 210008, P. R. 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