{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:28:08Z","timestamp":1787840888063,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate maternal and perinatal outcomes in preeclampsia (PE), according to the value of albumin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Preeclamptic women were retrospectively divided into mild hypoproteinemia (MHP,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 220) and severe hypoproteinemia (SHP,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 79) PE according to the value of albumin. The maternal and perinatal outcomes were evaluated in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two hundred and ninety-nine single pregnancies complicated by PE were included in this study. Gestational age at delivery was earlier in SHP than MHP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Severe hypertension, abnormal liver function, abnormal renal function, ascites, and abruption occurred more frequently in SHP than in MHP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01, 0.03, &lt;0.01, 0.01, and 0.04, respectively). Women in SHP had a higher rate of cesarean section than those in MHP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). Fetal growth restriction infants were more frequent in SHP than in MHP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). The occupancy rate of the Neonatal Intensive Care Unit was higher in SHP than in MHP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SHP PE is associated with a higher risk of adverse pregnancy outcome than MHP PE, deserving closer surveillance during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1735-1995.193170","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T07:06:00Z","timestamp":1477638360000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Association of hypoproteinemia in preeclampsia with maternal and perinatal outcomes: A retrospective analysis of high-risk women"],"prefix":"10.4103","volume":"21","author":[{"given":"Hongbo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, China"},{"name":"Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Anesthesiology, Maternal and Child Health Hospital, Anhui Province, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xietong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"R2-20250827","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R3-20250827","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0002-9378(76)90671-2","article-title":"Influence of blood pressure changes with and without proteinuria upon outcome of pregnancy","volume":"126","author":"Page","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"R4-20250827","first-page":"1122","article-title":"American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"R5-20250827","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1471-0528.2011.03232.x","article-title":"Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: A retrospective cohort study","volume":"119","author":"Hawkins","year":"2012","journal-title":"BJOG"},{"key":"R6-20250827","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1741-7015-7-10","article-title":"Estimation of proteinuria as a predictor of complications of pre-eclampsia: A systematic review","volume":"7","author":"Thangaratinam","year":"2009","journal-title":"BMC Med"},{"key":"R7-20250827","first-page":"569","article-title":"Clinical guideline. Preeclampsia-eclampsia","volume":"50","author":"Romero-Arauz","year":"2012","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"R8-20250827","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1701-2163(15)30588-0","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: Executive summary","volume":"36","author":"Magee","year":"2014","journal-title":"J Obstet Gynaecol Can"},{"key":"R9-20250827","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/10641955.2013.837172","article-title":"Hypoproteinemia in the second trimester among patients with preeclampsia prior to the onset of clinical symptoms","volume":"33","author":"Takahashi","year":"2014","journal-title":"Hypertens Pregnancy"},{"issue":"6 Pt 1","key":"R10-20250827","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0002-9378(89)90900-9","article-title":"Central hemodynamic assessment of normal term pregnancy","volume":"161","author":"Clark","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"R11-20250827","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/jp.2015.138","article-title":"Isolated proteinuria is a risk factor for pre-eclampsia: A retrospective analysis of the maternal and neonatal outcomes in women presenting with isolated gestational proteinuria","volume":"36","author":"Shinar","year":"2016","journal-title":"J Perinatol"},{"key":"R12-20250827","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3109\/10641955.2015.1015731","article-title":"Pregnancy outcome in proteinuria-onset and hypertension-onset preeclampsia","volume":"34","author":"Sarno","year":"2015","journal-title":"Hypertens Pregnancy"},{"key":"R13-20250827","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tcm.2008.07.002","article-title":"Novel biomarkers for predicting preeclampsia","volume":"18","author":"Carty","year":"2008","journal-title":"Trends Cardiovasc Med"},{"key":"R14-20250827","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.109.853127","article-title":"Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease","volume":"123","author":"Powe","year":"2011","journal-title":"Circulation"},{"key":"R15-20250827","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12884-015-0624-y","article-title":"Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia","volume":"15","author":"Turpin","year":"2015","journal-title":"BMC Pregnancy Childbirth"},{"key":"R16-20250827","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11883-013-0395-8","article-title":"Hypertension in pregnancy","volume":"16","author":"Vest","year":"2014","journal-title":"Curr Atheroscler Rep"},{"key":"R17-20250827","doi-asserted-by":"crossref","first-page":"e100180","DOI":"10.1371\/journal.pone.0100180","article-title":"The 2011 survey on hypertensive disorders of pregnancy (HDP) in China: Prevalence, risk factors, complications, pregnancy and perinatal outcomes","volume":"9","author":"Ye","year":"2014","journal-title":"PLoS One"},{"key":"R18-20250827","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0143-4004(03)00063-8","article-title":"Factors regulating trophoblast migration and invasiveness: Possible derangements contributing to pre-eclampsia and fetal injury","volume":"24","author":"Lala","year":"2003","journal-title":"Placenta"},{"key":"R19-20250827","first-page":"1","article-title":"A brief overview of preeclampsia","volume":"6","author":"Al-Jameil","year":"2014","journal-title":"J Clin Med Res"},{"key":"R20-20250827","doi-asserted-by":"crossref","first-page":"685","DOI":"10.12891\/ceog1939.2015","article-title":"Severe ascites as the primary symptom of fulminant postpartum HELLP syndrome: A case report","volume":"42","author":"Tan","year":"2015","journal-title":"Clin Exp Obstet Gynecol"},{"key":"R21-20250827","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/0377-4929.77317","article-title":"Spectrum of changes in placenta in toxemia of pregnancy","volume":"54","author":"Narasimha","year":"2011","journal-title":"Indian J Pathol Microbiol"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01222967-201621000-00098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:31:38Z","timestamp":1787837498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01222967-201621000-00098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/1735-1995.193170","relation":{},"ISSN":["1735-1995","1735-7136"],"issn-type":[{"value":"1735-1995","type":"print"},{"value":"1735-7136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}