{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:44Z","timestamp":1787840384302,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Osteoporosis affects quality of life (QoL) and may lead to depression in women. The purpose of this study was to evaluate the effects of zoledronic acid (ZA) treatment on depression and QoL in women with postmenopausal osteoporosis (PO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 88 newly diagnosed women with PO were included in this study. All patients were treated with once-yearly ZA (5 mg). A QoL questionnaire from the European Foundation for Osteoporosis and Beck Depression Inventory were given to patients at baseline and at 12 months. The results for baseline and post - 12\n                      <jats:sup>th<\/jats:sup>\n                      month were compared, and bone mineral density (BMD) levels were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The consumption of once-yearly ZA (5 mg) treatment increases BMD at levels of lumbers 1\u20134 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026), total Hip T score's\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value is same as femoral neck (P: 0,033). ZA 5 mg treatment also improved QoL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) and reduced depression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ZA treatment increases BMD levels and QoL while reducing depression. Once-yearly ZA (5 mg) may be considered for postmenopausal women as a first-line treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1735-1995.193503","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T04:16:34Z","timestamp":1478492194000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: A clinical trial study"],"prefix":"10.4103","volume":"21","author":[{"given":"Feyzi","family":"Gokosmanoglu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sakarya University Research and Training Hospital, Sakarya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhun","family":"Varim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Sakarya University, 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