{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:11:32Z","timestamp":1793052692319,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>Marine algae are potential renewable and sustainable sources of bioactive natural products which can be utilized in nutraceutical and pharmaceutical industries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach:<\/jats:title>\n                    <jats:p>\n                      Different extracts (methanol, chloroform, and ethyl acetate) of red algae,\n                      <jats:italic toggle=\"yes\">Laurencia snyderiae<\/jats:italic>\n                      , was evaluated for their antioxidant potential, with various antioxidant assessment assays, cytotoxic properties (using MTT colorimetric assay), and phytochemical constituents (total phenolic and flavonoid contents). The GC-MS analyses of the algal methanolic extract and its apoptotic effects on the human colon carcinoma cell line (HT29) were also investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings\/Results:<\/jats:title>\n                    <jats:p>\n                      The total phenolic content in the methanol, chloroform, and ethyl acetate extracts of\n                      <jats:italic toggle=\"yes\">L. snyderiae<\/jats:italic>\n                      was 3.6 \u00b1 0.12, 3.2 \u00b1 0.41, and 3.3 \u00b1 0.35 \u03bcg\/mg of gallic acid, respectively. Among different algae extracts, chloroform extract showed significantly chelating ability (IC\n                      <jats:sub>50<\/jats:sub>\n                      = 0.027 mg\/mL) and reducing power activity (IC\n                      <jats:sub>50<\/jats:sub>\n                      = 0.082 mg\/mL), while the highest DPPH scavenging activity (IC\n                      <jats:sub>50<\/jats:sub>\n                      = 0.058 mg\/mL) exhibited in the methanol extract compared to the other extracts. The methanolic extract was found to have a higher cytotoxicity effect on colon carcinoma cells with IC\n                      <jats:sub>50<\/jats:sub>\n                      70.2 \u03bcg\/mL. The viability of the cancer cells was increased with the decrease in the concentration in different extracts. GC-MS analysis of the algal methanolic extract revealed the presence of active antitumor constituents and apoptosis-based cytotoxicity against colon cancer cells through the DNA damage was also confirmed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and implications:<\/jats:title>\n                    <jats:p>\n                      Based on these results, the red algae\n                      <jats:italic toggle=\"yes\">L. snyderiae<\/jats:italic>\n                      possesses potent bioactive constituents and can use as additional resources as a natural antioxidant and antitumor agent in the pharmaceutical and nutraceutical area.\n                    <\/jats:p>\n                  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