{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:29Z","timestamp":1787758289014,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"\n Background and purpose:<\/jats:title>\n \n Phytochemically,\n Allium<\/jats:italic>\n species are a rich source of important secondary metabolites especially steroidal saponin and sapogenins, flavonoids, and sulfur compounds. As a member of this genus,\n Allium affine<\/jats:italic>\n , which is locally known as \u201ctareh kouhi\u201d, is an endemic plant of middle Asian countries.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental approach:<\/jats:title>\n \n Bulbs of\n A. affine<\/jats:italic>\n were collected and air-dried in the shade. The\n chloroform<\/jats:underline>\n -methanol (\n 9<\/jats:underline>\n :1) extract of the sample was subjected to purification by MPLC and HPLC. Structure elucidation of isolated compounds was done using comprehensive spectroscopic methods including 1D-NMR, 2D-NMR, and MS.\n <\/jats:p>\n <\/jats:sec>\n \n Findings\/Results:<\/jats:title>\n A steroidal saponin structurally related to parillin and a phenylpropanoid glycoside (coniferin) were isolated and identified from the plant chloroform-methanol extract.<\/jats:p>\n <\/jats:sec>\n \n Conclusion and implication:<\/jats:title>\n \n To the best of our knowledge isolation of these potentially medicinal compounds from\n A. affine<\/jats:italic>\n was reported for the first time in this study.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/1735-5362.359438","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:43:11Z","timestamp":1666572191000},"page":"723-727","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Isolation and identification of 6-methoxy parillin and coniferin from the bulbs of Allium affine L."],"prefix":"10.4103","volume":"17","author":[{"given":"Narges","family":"Vakili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Esmaeilifallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud S","family":"Dinani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240909","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.phytol.2013.04.007","article-title":"Antifungal cinnamic acid derivatives from Persian leek (Allium ampeloprasum Subsp","volume":"6","author":"Sadeghi","year":"2013","journal-title":"Persicum). Phytochem Lett"},{"key":"R2-11-20240909","first-page":"1","article-title":"Scape anatomy of Allium sect","volume":"35","author":"Miryeganeh","year":"2009","journal-title":"Allium (Alliaceae) in Iran. J Sci"},{"key":"R4-11-20240909","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4103\/1735-5362.212047","article-title":"Evaluation of fibrinolytic and antioxidant effects of Allium affine hydroalcoholic extract","volume":"12","author":"Sadeghi","year":"2017","journal-title":"Res Pharm Sci"},{"key":"R5-11-20240909","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/abr.abr_34_17","article-title":"Isolation of cinnamic acid derivatives from the bulbs of Allium tripedale","volume":"7","author":"Chehri","year":"2018","journal-title":"Adv Biomed Res"},{"key":"R6-11-20240909","first-page":"469","article-title":"Isolation of dioscin-related steroidal saponin from the bulbs of Allium paradoxum L","volume":"13","author":"Rezaee","year":"2018","journal-title":"with leishmanicidal activity. Res Pharm Sci"},{"key":"R7-11-20240909","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/1097-0231(20000730)14:14<1280::AID-RCM26>3.0.CO;2-C","article-title":"Rapid identification of saponins in plant extracts by electrospray ionization multi\u2010stage tandem mass spectrometry and liquid chromatography\/tandem mass spectrometry","volume":"14","author":"Cui","year":"2000","journal-title":"Rapid Commun Mass Spectrom"},{"key":"R8-11-20240909","first-page":"83","article-title":"Cytotoxic effects of Allium affine Ledeb butanolic fraction on breast and ovary cancer cell lines","volume":"16","author":"Kazemi","year":"2017","journal-title":"J Med Plants"},{"key":"R9-11-20240909","first-page":"113","article-title":"Ethnobotanical study of medicinal plants of Sardasht, Western Azerbaijan, Northwestern Iran","volume":"6","author":"Azizi","year":"2015","journal-title":"J Herb Drugs"},{"key":"R10-11-20240909","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.steroids.2012.01.009","article-title":"Steroidal saponins from the roots of Smilax sp.: structure and bioactivity","volume":"77","author":"Challinor","year":"2012","journal-title":"Steroids"},{"key":"R11-11-20240909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-014-9381-1","article-title":"Steroidal saponins from the genus Allium","volume":"15","author":"Sobolewska","year":"2016","journal-title":"Phytochem Rev"},{"key":"R12-11-20240909","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.steroids.2012.01.009","article-title":"Steroidal saponins from the roots of Smilax sp.: structure and bioactivity","volume":"77","author":"Challinor","year":"2012","journal-title":"Steroids"},{"key":"R13-11-20240909","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/2322-1232.254749","article-title":"Isolation of phenyl propanoid glycosides from Allium tripedale Trautv","volume":"7","author":"Ghaffari","year":"2018","journal-title":"J Rep Pharm Sci"},{"key":"R14-11-20240909","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0031-9422(00)81540-X","article-title":"Coniferin-an astringent glycoside in citrus","volume":"26","author":"Tatum","year":"1986","journal-title":"Phytochemistry"},{"key":"R15-11-20240909","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1139\/b89-343","article-title":"Coniferin, a biochemical indicator of commitment to tracheid differentiation in conifers","volume":"67","author":"Savidge","year":"1989","journal-title":"Can J Bot"},{"key":"R16-11-20240909","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1023\/A:1022821600283","article-title":"Development of Linum flavum hairy root cultures for production of coniferin","volume":"25","author":"Lin","year":"2003","journal-title":"Biotechnol Lett"}],"container-title":["Research in Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1735-5362.359438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:12:46Z","timestamp":1787757166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1735-5362.359438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1735-5362.359438","relation":{},"ISSN":["1735-5362"],"issn-type":[{"value":"1735-5362","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}