{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:35Z","timestamp":1787761235434,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>\n                      Irritable bowel syndrome (IBS) is a disease that shows its impacts on many populations worldwide. It is known as a functional disorder of the gastrointestinal tract followed by diarrhea and fecal inconsistency. Due to the lack of treatment in the allopathic medicine system for IBS, people in the western world use different herbs as alternative medicine. In the present study, we evaluated the dried extract of\n                      <jats:italic toggle=\"yes\">Dracocephalum kotschyi<\/jats:italic>\n                      against IBS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach:<\/jats:title>\n                    <jats:p>\n                      In a randomized, double-blinded, placebo-controlled clinical trial, 76 diarrhea-predominant IBS patients were randomly assigned to two equal groups: the control group (given the placebo capsule containing 250 mg of dibasic calcium phosphate) and the treatment groups (given the capsule containing 75 mg of the dry extract of\n                      <jats:italic toggle=\"yes\">D. kotschyi<\/jats:italic>\n                      and 175 mg of dibasic calcium phosphate as filler). The study was conducted based on Rome III criteria. We studied symptoms included in Rome III criteria and divided the study into the duration of drug administration and four weeks after drug administration. These groups were compared with those of the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings\/Results:<\/jats:title>\n                    <jats:p>\n                      Significant improvements were found in the quality of life, temperament, and IBS symptoms throughout the treatment duration. Quality of life, temperature, and IBS symptoms were slightly decreased in the treatment group 4 weeks after stopping the treatment. While concluding the study, we found\n                      <jats:italic toggle=\"yes\">D. kotschyi<\/jats:italic>\n                      effective against IBS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and implications:<\/jats:title>\n                    <jats:p>\n                      Whole extract of\n                      <jats:italic toggle=\"yes\">D. kotschyi<\/jats:italic>\n                      modulated symptoms of IBS patients and improved their quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1735-5362.363599","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T04:46:59Z","timestamp":1671857219000},"page":"89-99","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["A double-blind randomized clinical trial of Dracocephalum kotschyi Boiss. in the patients with diarrhea-predominant irritable bowel syndrome"],"prefix":"10.4103","volume":"18","author":[{"given":"Parisa","family":"Heydari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ghanadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Asghari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Azimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Babaeian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Adibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240909","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Mearin","year":"2016","journal-title":"Gastroenterology"},{"key":"R2-9-20240909","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/jcm6110099","article-title":"Rome criteria and a diagnostic approach of irritable bowel syndrome","volume":"6","author":"Lacy","year":"2017","journal-title":"J Clin Med"},{"key":"R3-9-20240909","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.3748\/wjg.14.2639","article-title":"Updates on treatment of irritable bowel syndrome","volume":"14","author":"Hammerle","year":"2008","journal-title":"World J Gastroenterol"},{"key":"R4-9-20240909","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2015.0954","article-title":"Irritable bowel syndrome: a clinical review","volume":"313","author":"Chey","year":"2015","journal-title":"JAMA"},{"key":"R5-9-20240909","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/pgmj.2007.060202","article-title":"A systematic review of randomised clinical trials of individualised herbal medicine in any indication","volume":"83","author":"Guo","year":"2007","journal-title":"Postgrad Med J"},{"key":"R6-9-20240909","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1726-4901(09)70375-2","article-title":"Treatment of irritable bowel syndrome using complementary and alternative medicine","volume":"72","author":"Chang","year":"2009","journal-title":"J Chin Med Assoc"},{"key":"R8-9-20240909","first-page":"158","article-title":"Antibacterial activity of various extracts from Dracocephalum kotschyi against food pathogenic microorganisms","volume":"8","author":"Kamali","year":"2015","journal-title":"Int J Pharmtech Res"},{"key":"R9-9-20240909","doi-asserted-by":"crossref","first-page":"e57870","DOI":"10.5812\/jjcdc.57870","article-title":"Evaluation of treatment response and side effects of spinal-Z in patients with metastatic gastroesophageal adenocarcinoma: a double-blind randomized controlled trial","volume":"6","author":"Mashak","year":"2017","journal-title":"Jundishapur J Chronic Dis Care"},{"key":"R10-9-20240909","first-page":"446","article-title":"Antispasmodic effect of Dracocephalum kotschyi hydroalcoholic extract on rat ileum contraction","volume":"10","author":"Sadraei","year":"2015","journal-title":"Res Pharm Sci"},{"key":"R11-9-20240909","first-page":"1","article-title":"Medicinal properties and active constituents of Dracocephalumkotschyi and its significance in Iran: a systematic review","volume":"2019","author":"Heydari","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"R12-9-20240909","first-page":"200","article-title":"Antidiarrhoeal assessment of hydroalcoholic and hexane extracts of Dracocephalum kotschyi Boiss","volume":"11","author":"Sadraei","year":"2016","journal-title":"and apigenin in mice. 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