{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:11:39Z","timestamp":1788541899376,"version":"build-2803163510"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>\n                      Huntington\u2019s disease (HD) is a neurodegenerative disease characterized by neuronal death in the striatum. Asiatic acid is an active component of\n                      <jats:italic toggle=\"yes\">Shorea robusta<\/jats:italic>\n                      (Dipterocarpaceae) plants with neuroprotective activity and is considered an acceptable therapeutic candidate for different neurodegenerative diseases. In the present study, the beneficial pharmacological action of\n                      <jats:italic toggle=\"yes\">Shorea robusta<\/jats:italic>\n                      resin extract (SRRE) was assessed in 3-nitropropionic acid (3-NP)-induced HD in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach:<\/jats:title>\n                    <jats:p>The neuroprotective effect of SRRE (285.7 and 666.7\u2009mg\/kg, p.o., 14 days) was studied in 3-NP (10 mg\/kg)-induced rats by measuring body weight, behavioral parameters including neurological scoring, motor coordination, spatial memory, and depression-like behavior, neuro-biochemical parameters (gamma-aminobutyric acid and acetylcholinesterase), and oxidative stress parameter in the brain. Histopathology of the rat\u2019s brain was also studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings\/Results:<\/jats:title>\n                    <jats:p>SRRE treatment (285.7 mg\/kg and 666.7 mg\/kg) substantially restored body weight, motor coordination, and mitochondrial enzyme complex I function and improved memory impairment as compared to 3-NP-treated rats. Furthermore, SRRE treatment significantly restored the antioxidant enzyme activity in brain tissue and ameliorated the histopathological changes induced by 3-NP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and implications:<\/jats:title>\n                    <jats:p>\n                      The neuroprotective effect of SRRE on 3-NP-induced HD in rats was mediated by a reduction in oxidative stress which may favor the usefulness of\n                      <jats:italic toggle=\"yes\">Shorea robusta<\/jats:italic>\n                      in HD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1735-5362.371586","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:14Z","timestamp":1678492814000},"page":"303-316","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Shorea robusta resin extract in 3-nitropropionic acid-induced Huntington\u2019s disease symptoms in Sprague-Dawley rats"],"prefix":"10.4103","volume":"18","author":[{"given":"Chirag","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, India-380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SSR College of Pharmacy, Silvassa, Dadra and Nagar Haveli, India-396230, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Shagond","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SSR College of Pharmacy, Silvassa, Dadra and Nagar Haveli, India-396230, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, SSR College of Pharmacy, Silvassa, Dadra and Nagar Haveli, India-396230, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Ranch","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, India-380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai HS.","family":"Boddu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, P.O. Box 346, United Arab Emirates."},{"name":"Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman P.O. 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