{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:18:07Z","timestamp":1760242687257},"reference-count":17,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>A 58-year-old man presented with productive cough and fever. Computed tomography (CT) scan of the chest showed an upper right paraspinal mass. CT-guided fine-needle aspiration biopsy showed lobules of vacuolated cells against a background of myxoid material. The cells demonstrated moderate to severe nuclear atypia and occasional mitoses. Immunohistochemistry revealed tumor cells to be immunoreactive for calretinin, WT-1, D2-40, cytokeratin (CK) 7, AE1\/AE3, high molecular weight keratin, vimentin and epithelial membrane antigen, and negative for thyroid transcription factor-1, Ber-EP4, carcinoembryonic antigen, S100 protein, CK20, and CDX2. The combined morphologic and immunohistochemical findings confirmed the diagnosis of microcystic variant of localized malignant mesothelioma. The subsequent lung resection showed a pleural-based mass in the right upper lobe and confirmed the diagnosis. Awareness of the existence of unusual morphologic variants and localized forms of mesothelioma are necessary to avoid misdiagnosis of fine needle biopsy samples. Recognition of characteristic cytomorphologic features along with optimal use of panel of immunohistochemistry studies is crucial for making a specific diagnosis.<\/jats:p>","DOI":"10.4103\/1742-6413.134438","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T07:20:51Z","timestamp":1402557651000},"page":"16","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microcystic variant malignant mesothelioma presenting as a localized paraspinal mass"],"prefix":"10.25259","volume":"11","author":[{"given":"Hyang Mi","family":"Ko","sequence":"first","affiliation":[{"name":"Address: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid Saeed","family":"Kamil","sequence":"additional","affiliation":[{"name":"Address: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Geddie","sequence":"additional","affiliation":[{"name":"Address: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2014,6,12]]},"reference":[{"key":"10.4103\/1742-6413.134438\/ref-1","article-title":"Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart","author":"Churg","year":"2004"},{"key":"10.4103\/1742-6413.134438\/ref-2","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/01.pas.0000165529.78945.dc","article-title":"Localized malignant mesothelioma","volume":"29","author":"Allen","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.4103\/1742-6413.134438\/ref-3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/icvts\/ivs542","article-title":"What is the survival after surgery for localized malignant pleural mesothelioma?","volume":"16","author":"Gelvez-Zapata","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.4103\/1742-6413.134438\/ref-4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.anndiagpath.2010.08.005","article-title":"Malignant mesothelioma with prominent adenomatoid features: A clinicopathologic and immunohistochemical study of 10 cases","volume":"15","author":"Weissferdt","year":"2011","journal-title":"Ann Diagn Pathol"},{"key":"10.4103\/1742-6413.134438\/ref-5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1046\/j.1440-1827.2002.01357.x","article-title":"Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion","volume":"52","author":"Umezu","year":"2002","journal-title":"Pathol Int"},{"key":"10.4103\/1742-6413.134438\/ref-6","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1309\/AJCPHV33LJTVDGJJ","article-title":"Histologic assessment and prognostic factors of malignant pleural mesothelioma treated with extrapleural pneumonectomy","volume":"130","author":"Arrossi","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.4103\/1742-6413.134438\/ref-7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.5858\/arpa.2012-0214-OA","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group","volume":"137","author":"Husain","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.4103\/1742-6413.134438\/ref-8","first-page":"874","article-title":"Mucin-positive epithelial mesothelioma","volume":"116","author":"MacDougall","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"10.4103\/1742-6413.134438\/ref-9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/01913129609016331","article-title":"Mucin-positive epithelial mesotheliomas: A histochemical, immunohistochemical, and ultrastructural comparison with mucin-producing pulmonary adenocarcinomas","volume":"20","author":"Hammar","year":"1996","journal-title":"Ultrastruct Pathol"},{"key":"10.4103\/1742-6413.134438\/ref-10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2559.2000.00937.x","article-title":"\u2018Mucin-positive\u2019 epithelial mesothelioma of the peritoneum: An unusual diagnostic pitfall","volume":"37","author":"Cook","year":"2000","journal-title":"Histopathology"},{"key":"10.4103\/1742-6413.134438\/ref-11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1440-1827.2009.02407.x","article-title":"Adenomatoid tumor of the pleura","volume":"59","author":"Minato","year":"2009","journal-title":"Pathol Int"},{"key":"10.4103\/1742-6413.134438\/ref-12","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1097\/00000478-199610000-00007","article-title":"Adenomatoid tumors of the pleura","volume":"20","author":"Kaplan","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.4103\/1742-6413.134438\/ref-13","article-title":"Cytopathologic Diagnosis of Serous Fluids","author":"Shidham","year":"2007"},{"key":"10.4103\/1742-6413.134438\/ref-14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ppul.1950110217","article-title":"Epithelioid hemangioendothelioma of the lung (intravascular bronchioloalveolar tumor) in a young girl","volume":"11","author":"Rock","year":"1991","journal-title":"Pediatr Pulmonol"},{"key":"10.4103\/1742-6413.134438\/ref-15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1183\/09031936.98.12010089","article-title":"Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression","volume":"12","author":"Kitaichi","year":"1998","journal-title":"Eur Respir J"},{"key":"10.4103\/1742-6413.134438\/ref-16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00292-006-0817-2","article-title":"Epithelioid hemangioendothelioma of the lung (IVBAT) - Clinicopathological and immunohistochemical analysis of 11 cases","volume":"27","author":"Einsfelder","year":"2006","journal-title":"Pathologe"},{"key":"10.4103\/1742-6413.134438\/ref-17","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/0046-8177(95)90301-1","article-title":"Chordomas of the mediastinum: Clinicopathologic, immunohistochemical, and ultrastructural study of six cases presenting as posterior mediastinal masses","volume":"26","author":"Suster","year":"1995","journal-title":"Hum Pathol"}],"container-title":["CytoJournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/microcystic-variant-malignant-mesothelioma-presenting-as-a-localized-paraspinal-mass\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/microcystic-variant-malignant-mesothelioma-presenting-as-a-localized-paraspinal-mass\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T01:29:51Z","timestamp":1580606991000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/microcystic-variant-malignant-mesothelioma-presenting-as-a-localized-paraspinal-mass\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,12]]},"references-count":17,"alternative-id":["10.4103\/1742-6413.134438"],"URL":"https:\/\/doi.org\/10.4103\/1742-6413.134438","relation":{},"ISSN":["0974-5963"],"issn-type":[{"value":"0974-5963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,12]]},"article-number":"16"}}