{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:58:45Z","timestamp":1783486725256,"version":"3.55.0"},"reference-count":35,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Background:<\/jats:title>The overall malignancy rate for the thyroid fine-needle aspiration (FNA) diagnosed as atypia of undetermined significance\/follicular lesion of undetermined significance (AUS\/FLUS) ranges from 5% to 30%. In this study, we present our institutional experience with thyroid nodules diagnosed as AUS\/FLUS and further stratified into subcategories. In addition, we also assessed the significance of various clinicopathologic factors that may influence AUS\/FLUS diagnoses and their outcomes.<\/jats:p><\/jats:sec>Design:<\/jats:title>A search of our laboratory information system was performed to identify all in-house thyroid FNA cases diagnosed as AUS\/FLUS from 2008 to 2012. The data were collected and characterized by patient demographic information, cytopathology diagnosis with sub-classifiers and follow-up.<\/jats:p><\/jats:sec>Results:<\/jats:title>The case cohort included 457 cases diagnosed as AUS\/FLUS. These were further sub-classified into one of six subcategories depending on the cytomorphologic findings and suspicion for or against a neoplastic process. Of the 457 cases, repeat FNA and\/or surgical follow-up was available in 363 cases. There were 182 (39.8%) cases with cytologic follow-up only; 18 (9.9%) remained as AUS\/FLUS, while 158 (86.8%) were re-classified with the majority being benign (142 cases). Histologic follow-up was available in 181 (39.6%) cases. There were 60 malignant cases confirmed by surgical excision, with an overall malignancy rate of 33.1%. The malignancy rate was 38.8% for cases with a repeat FNA versus 25.6% for cases that went directly to surgery without a repeat FNA. Papillary thyroid carcinoma accounted for 93.3% (56 cases) of the malignant cases.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Based on our study, even though the malignancy rate of AUS\/FLUS cases is similar to those reported for cases diagnosed as follicular neoplasm\/suspicious for follicular neoplasm, we are of the belief that these comparable malignancy rates are a product of better clinical management and selection of patients diagnosed as AUS\/FLUS for surgery after a repeat FNA.<\/jats:p><\/jats:sec>","DOI":"10.4103\/1742-6413.139725","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T07:14:15Z","timestamp":1409210055000},"page":"23","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Diagnosis of atypia\/follicular lesion of undetermined significance: An institutional experience"],"prefix":"10.25259","volume":"11","author":[{"given":"Lawrence 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