{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:11:52Z","timestamp":1769051512076,"version":"3.49.0"},"reference-count":31,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nEndoscopic ultrasound-guided transbronchial fine-needle aspiration (EBUS-TFNA) is a minimally invasive technique for diagnosis of mediastinal masses\/lesions. Although most studies have reported the utility of EBUS-TFNA in malignancy, its use has been extended to the benign conditions as well.<\/jats:p>\n<\/jats:sec>\n\nObjective:<\/jats:title>\nThe present study focused on utility of EBUS in contributing to reach the final diagnosis of sarcoidosis.<\/jats:p>\n<\/jats:sec>\n\nDesign:<\/jats:title>\nFrom May 2010 to December 2013, 19 of 80 patients who underwent EBUS-TFNA at one center for radiologically suspicious lesions for sarcoidosis, and with no definite histological diagnosis, were included in this retrospective study.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nWhen the histological diagnosis was taken as the gold standard, the sensitivity of EBUS-TFNA was 84.2% and specificity 100% with the positive predictive value of 100. The combined diagnostic sensitivity of EBUS-TFNA and transbronchial lung biopsy was 100%.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nEBUS is a valuable, minimally invasive diagnostic modality to support the diagnosis of sarcoidosis in appropriate clinical setting, after conventional work-up \u2013 particularly if patients have suspicious radiological findings. This minimally invasive procedure helps in providing a final diagnosis without exposing the patient to the risk of complications from more invasive procedures.<\/jats:p>\n<\/jats:sec>","DOI":"10.4103\/1742-6413.146118","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T06:21:16Z","timestamp":1417587676000},"page":"31","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Utility of endoscopic ultrasound-guided transbronchial fine-needle cytology in the diagnosis of sarcoidosis: A Saudi experience"],"prefix":"10.25259","volume":"11","author":[{"given":"Emad","family":"Raddaoui","sequence":"first","affiliation":[{"name":"Address: Department of Histopathology, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam H.","family":"Alhamad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaesta Naseem","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Address: Department of Histopathology, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Arafah","sequence":"additional","affiliation":[{"name":"Address: Department of Histopathology, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatmah Fahad","family":"AlHabeeb","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"10.4103\/1742-6413.146118\/ref-1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0029-1243890","article-title":"Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis","volume":"42","author":"Von Bartheld","year":"2010","journal-title":"Endoscopy"},{"key":"10.4103\/1742-6413.146118\/ref-2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/ard.61.5.385","article-title":"Sarcoidosis: TB or not TB?","volume":"61","author":"Litinsky","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.4103\/1742-6413.146118\/ref-3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1034\/j.1399-3003.1999.14d02.x","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World association for sarcoidosis and other granulomatous disorders","volume":"14","author":"Costabel","year":"1999","journal-title":"Eur Respir J"},{"key":"10.4103\/1742-6413.146118\/ref-4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cncy.21380","article-title":"The role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA) in the diagnosis of sarcoidosis","volume":"122","author":"Davis","year":"2014","journal-title":"Cancer Cytopathol"},{"key":"10.4103\/1742-6413.146118\/ref-5","first-page":"149","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. American Thoracic Society\/European Respiratory Society\/World Association of Sarcoidosis and other Granulomatous Disorders","volume":"16","author":"Hunninghake","year":"1999","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"10.4103\/1742-6413.146118\/ref-6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1378\/chest.120.1.109","article-title":"Endobronchial biopsy for sarcoidosis: A prospective study","volume":"120","author":"Shorr","year":"2001","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-7","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.rmed.2009.07.013","article-title":"The role of EBUS-TBNA for the diagnosis of sarcoidosis \u2013 comparisons with other bronchoscopic diagnostic modalities","volume":"103","author":"Nakajima","year":"2009","journal-title":"Respir Med"},{"key":"10.4103\/1742-6413.146118\/ref-8","first-page":"147","article-title":"Transbronchial needle aspiration improves the diagnostic yield of bronchoscopy in sarcoidosis","volume":"21","author":"Trisolini","year":"2004","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"10.4103\/1742-6413.146118\/ref-9","first-page":"736","article-title":"Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.4103\/1742-6413.146118\/ref-10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4103\/1742-6413.90081","article-title":"Utility of on-site evaluation of endobronchial ultrasound-guided transbronchial needle aspiration specimens","volume":"8","author":"Griffin","year":"2011","journal-title":"Cytojournal"},{"key":"10.4103\/1742-6413.146118\/ref-11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/1742-6413.64385","article-title":"Diagnostic difficulties and pitfalls in rapid on-site evaluation of endobronchial ultrasound guided fine needle aspiration","volume":"7","author":"Monaco","year":"2010","journal-title":"Cytojournal"},{"key":"10.4103\/1742-6413.146118\/ref-12","doi-asserted-by":"crossref","DOI":"10.3791\/1316","article-title":"Cell block preparation from cytology specimen with predominance of individually scattered cells","author":"Varsegi","year":"2009","journal-title":"J Vis Exp"},{"key":"10.4103\/1742-6413.146118\/ref-13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1378\/chest.113.1.147","article-title":"Mediastinoscopy in patients with presumptive stage I sarcoidosis: A risk\/benefit, cost\/benefit analysis","volume":"113","author":"Reich","year":"1998","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.05.00098404","article-title":"Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis","volume":"25","author":"Annema","year":"2005","journal-title":"Eur Respir J"},{"key":"10.4103\/1742-6413.146118\/ref-15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.gie.2007.07.049","article-title":"Diagnosis of intra-abdominal and mediastinal sarcoidosis with EUS-guided FNA","volume":"67","author":"Michael","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"10.4103\/1742-6413.146118\/ref-16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jtcvs.2007.11.011","article-title":"Transbronchial needle aspiration in sarcoidosis: Yield and predictors of a positive aspirate","volume":"135","author":"Trisolini","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.4103\/1742-6413.146118\/ref-17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1378\/chest.125.2.527","article-title":"Diagnostic value of transbronchial needle aspiration by Wang 22-gauge cytology needle in intrathoracic lymphadenopathy","volume":"125","author":"Cetinkaya","year":"2004","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-18","first-page":"43","article-title":"Minimally invasive diagnosis of sarcoidosis by EBUS when conventional diagnostics fail","volume":"27","author":"Eckardt","year":"2010","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"10.4103\/1742-6413.146118\/ref-19","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1164\/ajrccm.151.6.7767550","article-title":"Education and experience improve transbronchial needle aspiration performance","volume":"151","author":"Haponik","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.4103\/1742-6413.146118\/ref-20","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1378\/chest.12-0350","article-title":"Complications, consequences, and practice patterns of endobronchial ultrasound-guided transbronchial needle aspiration: Results of the AQuIRE registry","volume":"143","author":"Eapen","year":"2013","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-21","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1001\/jama.2013.5823","article-title":"Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: The granuloma randomized clinical trial","volume":"309","author":"Von Bartheld","year":"2013","journal-title":"JAMA"},{"key":"10.4103\/1742-6413.146118\/ref-22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/1742-6413.137760","article-title":"Utility and diagnostic accuracy of endobronchial ultrasound-guided transbronchial fine-needle aspiration cytology of mediastinal lesions: Saudi Arabian experience","volume":"11","author":"Raddaoui","year":"2014","journal-title":"Cytojournal"},{"key":"10.4103\/1742-6413.146118\/ref-23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1378\/chest.08-2768","article-title":"A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis","volume":"136","author":"Tremblay","year":"2009","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1183\/09031936.00111509","article-title":"The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis","volume":"35","author":"Tournoy","year":"2010","journal-title":"Eur Respir J"},{"key":"10.4103\/1742-6413.146118\/ref-25","first-page":"82","article-title":"Feasibility of cytological diagnosis of sarcoidosis with endobronchial US-guided transbronchial aspiration","volume":"29","author":"Kitamura","year":"2012","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"10.4103\/1742-6413.146118\/ref-26","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jtcvs.2012.01.040","article-title":"Prospective study of endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes versus transbronchial lung biopsy of lung tissue for diagnosis of sarcoidosis","volume":"143","author":"Oki","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.4103\/1742-6413.146118\/ref-27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1378\/chest.13-2339","article-title":"Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis","volume":"146","author":"Gupta","year":"2014","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-28","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1445-5994.2011.02446.x","article-title":"Diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration compared with transbronchial and endobronchial biopsy for suspected sarcoidosis","volume":"42","author":"Plit","year":"2012","journal-title":"Intern Med J"},{"key":"10.4103\/1742-6413.146118\/ref-29","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1378\/chest.118.4.928","article-title":"Diagnosing sarcoidosis using endosonography-guided fine-needle aspiration","volume":"118","author":"Fritscher-Ravens","year":"2000","journal-title":"Chest"},{"key":"10.4103\/1742-6413.146118\/ref-30","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-0030-1262207","article-title":"Diagnostic modalities in sarcoidosis: BAL, EBUS, and PET","volume":"31","author":"Costabel","year":"2010","journal-title":"Semin Respir Crit Care Med"},{"key":"10.4103\/1742-6413.146118\/ref-31","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.rmed.2012.02.014","article-title":"Efficacy and safety of convex probe EBUS-TBNA in sarcoidosis: A systematic review and meta-analysis","volume":"106","author":"Agarwal","year":"2012","journal-title":"Respir Med"}],"container-title":["CytoJournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/utility-of-endoscopic-ultrasound-guided-transbronchial-fine-needle-cytology-in-the-diagnosis-of-sarcoidosis-a-saudi-experience\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/utility-of-endoscopic-ultrasound-guided-transbronchial-fine-needle-cytology-in-the-diagnosis-of-sarcoidosis-a-saudi-experience\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T06:29:33Z","timestamp":1580624973000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/utility-of-endoscopic-ultrasound-guided-transbronchial-fine-needle-cytology-in-the-diagnosis-of-sarcoidosis-a-saudi-experience\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,3]]},"references-count":31,"alternative-id":["10.4103\/1742-6413.146118"],"URL":"https:\/\/doi.org\/10.4103\/1742-6413.146118","relation":{},"ISSN":["0974-5963"],"issn-type":[{"value":"0974-5963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,3]]},"article-number":"31"}}