{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T19:32:53Z","timestamp":1648755173341},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Atypical urine cytology (CYT) triggers a cystoscopic or another ancillary investigation that targets urothelial neoplasms. We report a case presenting as an unknown primary malignancy, which illustrated the diagnostic utility of direct double immunostaining for cytokeratin 20 (CK20)\/p53 expression in a urine CYT specimen. A 42-year-old woman visited the emergency room for pain in her right lower abdominal quadrant. Computed tomography revealed postrenal obstructive hydronephrosis, and her urine CYT showed malignancy, type undetermined. Atypical cells that are positive for cytoplasmic expression of CK20 and nuclear expression of p53 could facilitate the decision to perform a nephroureterectomy for urothelial carcinoma.<\/jats:p>","DOI":"10.4103\/1742-6413.194162","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T06:27:18Z","timestamp":1484548038000},"page":"26","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic utility of double immunostaining of a urine cytology preparation for cytokeratin 20\/p53 expression in a young woman with micropapillary urothelial carcinoma of the renal pelvis presenting as an unknown primary malignancy"],"prefix":"10.25259","volume":"13","author":[{"given":"Hyun-Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Address: Department of Pathology, Inje University, Sanggye Paik Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucky","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Urology, Inje University, Sanggye Paik Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Address: Department of Pathology, Inje University, Sanggye Paik Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongmee","family":"Park","sequence":"additional","affiliation":[{"name":"Address: Department of Pathology, Inje University, Sanggye Paik Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"10.4103\/1742-6413.194162\/ref-1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/jnci\/djr077","article-title":"Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system","volume":"103","author":"Kohler","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"3 Pt 1","key":"10.4103\/1742-6413.194162\/ref-2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0022-5347(05)67280-1","article-title":"Primary superficial bladder cancer risk groups according to progression, mortality and recurrence","volume":"164","author":"Mill\u00e1n-Rodr\u00edguez","year":"2000","journal-title":"J Urol"},{"key":"10.4103\/1742-6413.194162\/ref-3","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.eururo.2011.03.017","article-title":"EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update","volume":"59","author":"Babjuk","year":"2011","journal-title":"Eur Urol"},{"key":"10.4103\/1742-6413.194162\/ref-4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5489\/cuaj.600","article-title":"Biomarkers for detection and surveillance of bladder cancer","volume":"2","author":"Budman","year":"2008","journal-title":"Can Urol Assoc J"},{"key":"10.4103\/1742-6413.194162\/ref-5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000323652","article-title":"Multiprobe fluorescence in situ hybridization (UroVysion) for the detection of urothelial carcinoma \u2013 Fishing for the right catch","volume":"55","author":"Bubendorf","year":"2011","journal-title":"Acta Cytol"},{"key":"10.4103\/1742-6413.194162\/ref-6","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/S0022-5347(05)68934-3","article-title":"Immunocyt: A new tool for detecting transitional cell cancer of the urinary tract","volume":"161","author":"Mian","year":"1999","journal-title":"J Urol"},{"key":"10.4103\/1742-6413.194162\/ref-7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14040","article-title":"Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer","volume":"14","author":"Mowatt","year":"2010","journal-title":"Health Technol Assess"},{"key":"10.4103\/1742-6413.194162\/ref-8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/cncy.21247","article-title":"Combined application of cytology and molecular urine markers to improve the detection of urothelial carcinoma","volume":"121","author":"Todenh\u00f6fer","year":"2013","journal-title":"Cancer Cytopathol"},{"key":"10.4103\/1742-6413.194162\/ref-9","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/00000478-200108000-00013","article-title":"Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium: An analysis of cytokeratin 20, p53, and CD44 antigens","volume":"25","author":"McKenney","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.4103\/1742-6413.194162\/ref-10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/1742-6413.123784","article-title":"Evaluation of a triple combination of cytokeratin 20, p53 and CD44 for improving detection of urothelial carcinoma in urine cytology specimens","volume":"10","author":"Arville","year":"2013","journal-title":"Cytojournal"},{"key":"10.4103\/1742-6413.194162\/ref-11","first-page":"365","article-title":"cytological findings of the micropapillary variant of urothelial carcinoma: A comparison with typical High grade Urothelial carcinoma","volume":"47","author":"Kim","year":"2013","journal-title":"J Pathol Transl Med"},{"key":"10.4103\/1742-6413.194162\/ref-12","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.humpath.2014.04.015","article-title":"The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma","volume":"45","author":"Lin","year":"2014","journal-title":"Hum Pathol"}],"container-title":["CytoJournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/diagnostic-utility-of-double-immunostaining-of-a-urine-cytology-preparation-for-cytokeratin-20-p53-expression-in-a-young-woman-with-micropapillary-urothelial-carcinoma-of-the-renal-pelvis-presenting-a\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/diagnostic-utility-of-double-immunostaining-of-a-urine-cytology-preparation-for-cytokeratin-20-p53-expression-in-a-young-woman-with-micropapillary-urothelial-carcinoma-of-the-renal-pelvis-presenting-a\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T01:27:59Z","timestamp":1580606879000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/diagnostic-utility-of-double-immunostaining-of-a-urine-cytology-preparation-for-cytokeratin-20-p53-expression-in-a-young-woman-with-micropapillary-urothelial-carcinoma-of-the-renal-pelvis-presenting-a\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":12,"alternative-id":["10.4103\/1742-6413.194162"],"URL":"https:\/\/doi.org\/10.4103\/1742-6413.194162","relation":{},"ISSN":["0974-5963"],"issn-type":[{"value":"0974-5963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]},"article-number":"26"}}