{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:50:22Z","timestamp":1787889022174,"version":"build-2784847793"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":3405,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Background and Aim : The current advances in diagnostic and therapeutic modalities and increasing in survival of patients with systemic diseases and immunosuppressive cases have caused to increasing frequency and variety of Central Nervous System neuropathologic processes indicating the necessary need for accurate localization of space-occupying lesions by cytology and histology. This study was aimed to evaluate the usefulness and safety of stereotactic biopsy in histological diagnosis of such lesions. Materials and Methods: Of 2081 patients underwent stereotactic biopsy of brain lesions using Riechert-Mundinger system, 158 had multifocal brain lesions, and were enrolled. Results: The ages of studied cases were ranged from 2 years to 75 years (Mean age: 41.3 year), 114 were male and 44 were females. Incidence of histopathologic diagnosis of multifocal brain lesions included Astrocytoma grade II (41.3%), Astrocytoma grade I (12.9%), glioblastoma multiform (11.1%), Astrocytoma grade III (10.2%), malignant lymphoma (10.2%), metastasis (4.6%), pilocytic Astrocytoma (2.7%), abscess (2.7%), craniopharyngioma (1.8%) vascular malformations (0.9%), and tuberculosis (0.9%). Mortality due to operation is none. Conclusions : Histopathologic diagnosis of multiple brain lesions is necessary for decision of appropriate management and stereotactic biopsy of brain lesion is a useful and safe method for histological diagnosis.<\/jats:p>","DOI":"10.4103\/1793-5482.116374","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T08:34:21Z","timestamp":1376296461000},"page":"69-73","source":"Crossref","is-referenced-by-count":16,"title":["Role of stereotactic biopsy in histological diagnosis of multiple brain lesions"],"prefix":"10.1055","volume":"8","author":[{"given":"Ali","family":"Meshkini","sequence":"additional","affiliation":[{"name":"Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohrab","family":"Shahzadi","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery and Stereotaxy Research Center, Shahid Beheshti Medical University, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Alikhah","sequence":"additional","affiliation":[{"name":"Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Naghavi-Behzad","sequence":"additional","affiliation":[{"name":"Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"key-10.4103\/1793-5482.116374-1","first-page":"585","volume-title":"5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies","author":"von","year":"2012","journal-title":"Acta Neurochir (Wien)"},{"key":"key-10.4103\/1793-5482.116374-2","first-page":"2188","volume-title":"Inflammatory cortical demyelination in early multiple sclerosis","author":"Lucchinetti","year":"2011","journal-title":"N Engl J Med"},{"key":"key-10.4103\/1793-5482.116374-3","first-page":"411","volume-title":"Functional imaging in brain tumors","author":"Borb\u00e9ly","year":"2004","journal-title":"Orv Hetil"},{"key":"key-10.4103\/1793-5482.116374-4","first-page":"263","volume-title":"Stereotactic biopsy for multifocal, diffuse, and deep-seated brain tumors using Leksell\u2032s system","author":"Yamada","year":"2004","journal-title":"J Clin Neurosci"},{"key":"key-10.4103\/1793-5482.116374-5","first-page":"552","volume-title":"Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: Direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging measurements","author":"Hu","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"key-10.4103\/1793-5482.116374-6","first-page":"38","volume-title":"Multicentric glioblastoma multiforme determined by positron emission tomography: A case report","author":"Jawahar","year":"2003","journal-title":"Clin Neurol Neurosurg"},{"key":"key-10.4103\/1793-5482.116374-7","first-page":"407","volume-title":"Magnetization transfer ratio and myelin in post-mortem multiple sclerosis brain","author":"Schmierer","year":"2004","journal-title":"Ann Neurol"},{"key":"key-10.4103\/1793-5482.116374-8","first-page":"911","volume-title":"Peritumoral hemorrhage immediately after radiosurgery for metastatic brain tumor","author":"Uchino","year":"2003","journal-title":"No Shinkei Geka"},{"key":"key-10.4103\/1793-5482.116374-9","first-page":"9","volume-title":"Pathological features of intracranial germinomas with reference to fibrous tissue and granulomatous change","author":"Utsuki","year":"2005","journal-title":"Brain Tumor Pathol"},{"key":"key-10.4103\/1793-5482.116374-10","first-page":"17","volume-title":"The accuracy and diagnostic yield of computerized tomography guided stereotactic biopsy in brain lesions","author":"Cali\u00baaneller","year":"2008","journal-title":"Turk Neurosurg"},{"key":"key-10.4103\/1793-5482.116374-11","first-page":"23","volume-title":"Safety and efficacy of frameless and frame-based intracranial biopsy techniques","author":"Dammers","year":"2008","journal-title":"Acta Neurochir (Wien)"},{"key":"key-10.4103\/1793-5482.116374-12","first-page":"71","volume-title":"Correlation of diagnostic yield of stereotactic brain biopsy with number of biopsy bits and site of the lesion","author":"Jain","year":"2006","journal-title":"Brain Tumor Pathol"},{"key":"key-10.4103\/1793-5482.116374-13","first-page":"768","volume-title":"Progressive multifocal leukoencephalopathy in an HTLV-I carrier","author":"Kimura","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"key":"key-10.4103\/1793-5482.116374-14","first-page":"830","volume-title":"Clinical validation of true frameless stereotactic biopsy: Analysis of the first 125 consecutive cases","author":"Paleologos","year":"2001","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.116374-15","first-page":"596","volume-title":"Stereotactic co-registration of magnetic resonance imaging and histopathology in post-mortem multiple sclerosis brain","author":"Schmierer","year":"2003","journal-title":"Neuropathol Appl Neurobiol"},{"key":"key-10.4103\/1793-5482.116374-16","first-page":"957","volume-title":"Role of stereotactic biopsy in multifocal brain lesions: Considerations on 100 consecutive cases","author":"Franzini","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/1793-5482.116374-17","first-page":"188","volume-title":"Biopsy of thalamic lesions using computed imaging-assisted stereotaxis: Report of 15 years of experiences","author":"Shahzadi","year":"2005","journal-title":"Arch Iran Med"},{"key":"key-10.4103\/1793-5482.116374-18","first-page":"194","volume-title":"Cerebral lymphoma: Clinical and radiological findings in 90 cases","author":"Zali","year":"2007","journal-title":"Arch Iran Med"},{"key":"key-10.4103\/1793-5482.116374-19","first-page":"2145","volume-title":"Computed tomography-guided stereotactic biopsy of intracranial lesions in pediatric patients","author":"Meshkini","year":"2011","journal-title":"Childs Nerv Syst"},{"key":"key-10.4103\/1793-5482.116374-20","first-page":"311","volume-title":"Systemic juvenile xanthogranuloma with multiple central nervous system lesions","author":"Meshkini","year":"2012","journal-title":"J Cancer Res Ther"},{"key":"key-10.4103\/1793-5482.116374-21","first-page":"137","volume-title":"Stereotactic computed tomography-guided biopsy of brainstem lesions","author":"Meshkini","year":"2012","journal-title":"Neurosurg Q"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1793-5482.116374.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T22:37:08Z","timestamp":1664318228000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1793-5482.116374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":21,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,9,27]]},"published-print":{"date-parts":[[2013,6]]}},"URL":"https:\/\/doi.org\/10.4103\/1793-5482.116374","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}