{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:38:31Z","timestamp":1787683111060,"version":"build-2784847793"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":2210,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Melanocytic schwannoma (MS) is an extremely rare soft tissue tumor accounting for less than 1% of all primitive nerve sheath tumors, with a predilection for spinal nerve involvement. To date, only 20 cases of cutaneous\/subcutaneous MS have been described in literature.Here, we describe a case of MS presenting as a subcutaneous nodule in a 22-year-old male in right thigh. On examination, the nodule measured 2.5 x 2.0 x 1.5 cm with overlying skin showing a bluish hue and an ulcer. With a preoperative diagnosis of hemangioma, the patient was taken up for wide local excision and was diagnosed as a case of non psammomatous melanocytic schwannoma based on clinical, histological, and immunohistochemical studies. Immunohistochemistry revealed positivity with S-100, HMB-45, and Melan A with pericellular Laminin positivity. Carney's syndrome was ruled out. MS needs to be differentiated from other pigmented lesions like pigmented neurofibroma, Bednar tumor, cellular blue neavus, and especially malignant melanoma, which has an obvious ominous prognosis. Since MS can show unpredictable behavior especially in absence of overt malignant features, a long term follow up with or without radiotherapy is recommended.<\/jats:p>","DOI":"10.4103\/1793-5482.148789","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T07:03:16Z","timestamp":1420614196000},"page":"317-318","source":"Crossref","is-referenced-by-count":17,"title":["Non psammomatous melanocytic schwannoma presenting as a subcutaneous nodule: A rare presentation of a rare lesion"],"prefix":"10.1055","volume":"11","author":[{"given":"Harveen","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"key-10.4103\/1793-5482.148789-1","first-page":"1451","volume-title":"Clinicopathological, immunohistochemical and ultrastructural study of 13 cases of melanotic schwannoma","author":"Hong-ying","year":"2005","journal-title":"Chinese Med J"},{"key":"key-10.4103\/1793-5482.148789-2","first-page":"657","volume-title":"Intrathoracic Psammomatous Melanotic Schwannoma associated with the Carney Complex","author":"Mees","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"key-10.4103\/1793-5482.148789-3","first-page":"755","volume-title":"Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis","author":"K\u00fcsters-Vandevelde","year":"2010","journal-title":"Acta Neuropathol"},{"key":"key-10.4103\/1793-5482.148789-4","first-page":"438","volume-title":"Melanocytic schwannoma of the cutaneous and subcutaneous tissues: Three cases and a review of the literature","author":"Kaehler","year":"2008","journal-title":"Melanoma Res"},{"key":"key-10.4103\/1793-5482.148789-5","first-page":"351","volume-title":"A malignant melanotic tumour of ganglion cells arising from a thoracic sympathetic ganglion","author":"Millar","year":"1932","journal-title":"J Pathol Bacteriol"},{"key":"key-10.4103\/1793-5482.148789-6","first-page":"2029","volume-title":"Primary malignant melanocytic tumors of the sympathetic ganglia with an ultrastructural study of one","author":"Fu","year":"1975","journal-title":"Cancer"},{"key":"key-10.4103\/1793-5482.148789-7","first-page":"259","volume-title":"Psammomatous melanotic schwannoma: A disinctive heritable tumor with special associations including cardiac myxoma nd cushing syndrome","author":"Carney","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"key-10.4103\/1793-5482.148789-8","first-page":"925","volume-title":"Review: The pathobiologic spectrum of Schwannomas","author":"Kurtkaya-Yap\u0131c\u0131er","year":"2003","journal-title":"Histol Histopathol"},{"key":"key-10.4103\/1793-5482.148789-9","first-page":"558","volume-title":"Spinal Melanotic Schwannoma: A tumour with poor prognosis","author":"Vallat-Decouvelaere","year":"1999","journal-title":"Histopathology"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1793-5482.148789.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T23:07:11Z","timestamp":1663715231000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1793-5482.148789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":9,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,9,20]]},"published-print":{"date-parts":[[2016,9]]}},"URL":"https:\/\/doi.org\/10.4103\/1793-5482.148789","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}