{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:13:26Z","timestamp":1787498006827,"version":"build-2736575974"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":2487,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant familial tumor syndrome. Glioblastoma is a malignant brain tumor but is a rare occurrence in patients with NF1. Here, we report a rare occurrence of glioblastoma in a 60-year-old man with NF1, who presented with headache, neck pain, and gait unsteadiness of 3 days duration. He also had postural hypotension. Motor examination revealed left hemiparesis. Multiple subcutaneous soft swellings and multiple caf\u03b9-au-lait spots were seen all over his body. He also had inguinal and axillary freckling. Abdominal imaging revealed a right suprarenal mass suggestive of cystic pheochromocytoma. Brain imaging revealed a predominantly cystic intra-axial right frontal space occupying lesion (SOL) with enhancing solid component, perilesional edema, and mass effect. The patient underwent laparoscopic removal of right adrenal mass after being adequately \"blocked\" by an alpha blocker-prazosin. Thereafter, he underwent right frontal craniotomy and gross total excision of right frontal infiltrative SOL. The postoperative period was uneventful. Patient underwent adjuvant radiotherapy and chemotherapy.<\/jats:p>","DOI":"10.4103\/1793-5482.162728","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:25:59Z","timestamp":1439425559000},"page":"344-347","source":"Crossref","is-referenced-by-count":5,"title":["A rare case of neurofibromatosis - type 1"],"prefix":"10.1055","volume":"10","author":[{"given":"Prithvi","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lakeshore Hospital and Research Centre, Ernakulam, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Abdul Jalal","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Lakeshore Hospital and Research Centre, Ernakulam, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"key-10.4103\/1793-5482.162728-1","first-page":"1","volume-title":"Epidemiology of neurofibromatosis type 1","author":"Friedman","year":"1999","journal-title":"Am J Med Genet"},{"key":"key-10.4103\/1793-5482.162728-2","first-page":"1225","volume-title":"Neurofibromatosis and childhood tumors","author":"Blatt","year":"1986","journal-title":"Cancer"},{"key":"key-10.4103\/1793-5482.162728-3","first-page":"477","volume-title":"Malignancy in neurofibromatosis type 1","author":"Korf","year":"2000","journal-title":"Oncologist"},{"key":"key-10.4103\/1793-5482.162728-4","first-page":"181","volume-title":"Type 1 neurofibromatosis gene: Identification of a large transcript disrupted in three NF1 patients","author":"Wallace","year":"1990","journal-title":"Science"},{"key":"key-10.4103\/1793-5482.162728-5","first-page":"1397","volume-title":"Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1","author":"Gutmann","year":"2003","journal-title":"Neurology"},{"key":"key-10.4103\/1793-5482.162728-6","first-page":"119","volume-title":"Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma","author":"Zhu","year":"2005","journal-title":"Cancer Cell"},{"key":"key-10.4103\/1793-5482.162728-7","first-page":"717","volume-title":"Neurofibromatosis and glioblastoma in a case of multiple sclerosis","author":"P\u00e1l","year":"2001","journal-title":"Eur J Neurol"},{"key":"key-10.4103\/1793-5482.162728-8","first-page":"362","volume-title":"Case report on a patient with neurofibromatosis type 1 and a frontal cystic glioblastoma","author":"Hakan","year":"2008","journal-title":"Neurol Neurochir Pol"},{"key":"key-10.4103\/1793-5482.162728-9","first-page":"757898","volume-title":"Glioblastoma multiforme in the posterior cranial fossa in a patient with neurofibromatosis type I","author":"Broekman","year":"2009","journal-title":"Case Rep Med"},{"key":"key-10.4103\/1793-5482.162728-10","first-page":"36","volume-title":"Glioblastoma in a patient with neurofibromatosis type 1: A case report and review of the literature","author":"Jeong","year":"2014","journal-title":"Brain Tumor Res Treat"},{"key":"key-10.4103\/1793-5482.162728-11","first-page":"890","volume-title":"Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1","author":"Huttner","year":"2010","journal-title":"Pediatr Blood Cancer"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1793-5482.162728.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T23:22:49Z","timestamp":1663888969000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1793-5482.162728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":11,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,9,22]]},"published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.4103\/1793-5482.162728","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}