{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:42:21Z","timestamp":1789684941326,"version":"4.0.1"},"reference-count":60,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":1845,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Risk factors for cerebral aneurysms typically include age, hypertension, smoking, and alcohol usage. However, the possible connection of aneurysms with genetic conditions such as Marfan's syndrome, polycystic kidney disease, and neurofibromatosis raises the question of possible genetic risk factors for aneurysm, and additionally, genetic risk factors for rupture. We conducted a literature review using the PubMed database for studies regarding genetic correlation with cerebral aneurysm formation as well as rupture from December 2008 to Jun 2015. Twenty-one studies related to IA formation and 10 concerning IA rupture that met our criteria were found and tabulated. The most studied gene and the strongest association was 9p21\/CDKN2, which is involved in vessel wall remodelling. Other possible genes that may contribute to IA formation include EDNRA and SOX17; however, these factors were not studied as robustly as CDKN2. Multiple factors contribute to aneurysm formation and rupture and the contributions of blood flow dynamics and comorbidities as mentioned previously, cannot be ignored. While these elements are important to development and rupture of aneurysms, genetic influence may predispose certain patients to formation of aneurysms and eventual rupture.<\/jats:p>","DOI":"10.4103\/1793-5482.180972","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T06:45:48Z","timestamp":1461221148000},"page":"374-381","source":"Crossref","is-referenced-by-count":19,"title":["Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage"],"prefix":"10.1055","volume":"12","author":[{"given":"Christian","family":"Theodotou","sequence":"additional","affiliation":[{"name":"Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Snelling","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Sur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Haussen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elhammady","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"key-10.4103\/1793-5482.180972-1","first-page":"626","volume-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis","author":"Vlak","year":"2011","journal-title":"Lancet Neurol"},{"key":"key-10.4103\/1793-5482.180972-2","first-page":"2414","volume-title":"Natural history of unruptured intracranial aneurysms: A long-term follow-up study","author":"Juvela","year":"2013","journal-title":"Stroke"},{"key":"key-10.4103\/1793-5482.180972-3","first-page":"99","volume-title":"Management of unruptured intracranial aneurysms","author":"Williams","year":"2013","journal-title":"Neurol Clin Pract"},{"key":"key-10.4103\/1793-5482.180972-4","first-page":"1","volume-title":"Factors affecting formation and rupture of intracranial saccular aneurysms","author":"Bacigaluppi","year":"2014","journal-title":"Neurosurg Rev"},{"key":"key-10.4103\/1793-5482.180972-5","first-page":"1632","volume-title":"Marfan syndrome is not associated with intracranial aneurysms","author":"Conway","year":"1999","journal-title":"Stroke"},{"key":"key-10.4103\/1793-5482.180972-6","first-page":"866","volume-title":"Intracranial aneurysms in Marfan's syndrome: An autopsy study","author":"Schievink","year":"1997","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.180972-7","first-page":"30","volume-title":"Familial association of intracranial aneurysms and multiple congenital anomalies","author":"ter","year":"1986","journal-title":"Arch Neurol"},{"key":"key-10.4103\/1793-5482.180972-8","first-page":"10","volume-title":"Is Marfan syndrome associated with symptomatic intracranial aneurysms?","author":"van","year":"1996","journal-title":"Stroke"},{"key":"key-10.4103\/1793-5482.180972-9","first-page":"45","volume-title":"Frequency of incidental intracranial aneurysms in neurofibromatosis type 1","author":"Schievink","year":"2005","journal-title":"Am J Med Genet A"},{"key":"key-10.4103\/1793-5482.180972-10","first-page":"213","volume-title":"Cerebral aneurysms associated with von Recklinghausen's neurofibromatosis: Report of a case and review of the literature","author":"Baldauf","year":"2005","journal-title":"Neurol India","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3886","issn-type":"print"},{"key":"key-10.4103\/1793-5482.180972-11","first-page":"533","volume-title":"Renal and extrarenal manifestations of autosomal dominant polycystic kidney disease","author":"Rom\u00e3o","year":"2006","journal-title":"Braz J Med Biol Res"},{"key":"key-10.4103\/1793-5482.180972-12","first-page":"1400","volume-title":"Risk of intracranial aneurysm bleeding in autosomal-dominant polycystic kidney disease","author":"Ring","year":"2007","journal-title":"Kidney 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