{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:20:42Z","timestamp":1776774042706,"version":"3.51.2"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":1754,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Disseminated tuberculomas in the brain and spinal cord are rare. To the best of our knowledge, only nine cases of spinal intra-medullary tuberculomas with cranial involvement have been reported till date. However, involvement of all levels in the spinal cord, brain stem with pan lobar involvement of the cerebrum and cerebellum has not been reported so far. We present such a case of a 12-year-old boy with history of pulmonary tuberculosis, who presented with gradual onset of quadriparesis and generalized seizures. We have discussed the unusual clinical presentation and the temporal changes in magnetic resonance imaging features along with clinical response to treatment. In cases reported so far, the plan of surgical versus medical management has been opted for variably, in cases of spinal intra-medullary involvement with acute neurological deficit. The decision is even more difficult in multilevel spinal intra-medullary tuberculomas. Our patient showed good clinico-radiological improvement with medical management.<\/jats:p>","DOI":"10.4103\/1793-5482.185073","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T07:13:44Z","timestamp":1467270824000},"page":"774-778","source":"Crossref","is-referenced-by-count":8,"title":["Concurrent multilevel spinal intra-medullary with extensive intracranial tuberculomas: A rare case report"],"prefix":"10.1055","volume":"12","author":[{"given":"Shyam","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services, Taramani, Chennai, Tamil Nadu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavinkumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services, Taramani, Chennai, Tamil Nadu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madabushi","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services, Taramani, Chennai, Tamil Nadu"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"key-10.4103\/1793-5482.185073-1","first-page":"432","volume-title":"Intramedullary tuberculomas of the spinal cord: Case report and review","author":"MacDonnell","year":"1990","journal-title":"Rev Infect Dis"},{"key":"key-10.4103\/1793-5482.185073-2","first-page":"213","volume-title":"Disseminated tuberculomas in spinal cord and brain demonstrated by MRI with gadolinium-DTPA","author":"Shen","year":"1993","journal-title":"Neuroradiology"},{"key":"key-10.4103\/1793-5482.185073-3","first-page":"218","volume-title":"Neuroimages of disseminated neurotuberculosis: Report of one case","author":"Huang","year":"1999","journal-title":"Clin Imaging"},{"key":"key-10.4103\/1793-5482.185073-4","first-page":"368","volume-title":"Intradural extramedullary tuberculoma of the spinal cord: A case report","author":"Kim","year":"2000","journal-title":"J Korean Med Sci"},{"key":"key-10.4103\/1793-5482.185073-5","first-page":"E499","volume-title":"Multiple tuberculomas in the brain and spinal cord: A case report","author":"Yen","year":"1976","journal-title":"Spine (Phila Pa"},{"key":"key-10.4103\/1793-5482.185073-6","first-page":"107","volume-title":"Concurrent intra-medullary and intra-cranial tuberculomas","author":"Thacker","year":"2004","journal-title":"J Postgrad Med","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3859","issn-type":"print"},{"key":"key-10.4103\/1793-5482.185073-7","first-page":"514","volume-title":"Concurrent intramedullary and intracerebral tuberculomas","author":"Shenoy","year":"2004","journal-title":"Neurol India","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3886","issn-type":"print"},{"key":"key-10.4103\/1793-5482.185073-8","first-page":"69","volume-title":"Surgery for intramedullary tuberculoma of the spinal cord: Report of 2 cases","author":"Muthukumar","year":"2006","journal-title":"Surg Neurol"},{"key":"key-10.4103\/1793-5482.185073-9","first-page":"169","volume-title":"En plaque intradural extramedullary spinal tuberculoma and concurrent intracranial tuberculomas: Paradoxical response to antituberculous therapy.Case report","author":"Muthukumar","year":"2007","journal-title":"J Neurosurg Spine"},{"key":"key-10.4103\/1793-5482.185073-10","first-page":"36","volume-title":"Multiple tuberculoma involving the brain and spinal cord in a patient with miliary pulmonary tuberculosis","author":"Park","year":"2008","journal-title":"J Korean Neurosurg Soc"},{"key":"key-10.4103\/1793-5482.185073-11","first-page":"606","volume-title":"Co-occurrence of intracerebral tuberculoma with lumbar intramedullary tuberculoma","author":"Chitre","year":"2009","journal-title":"J Child Neurol"},{"key":"key-10.4103\/1793-5482.185073-12","first-page":"61","volume-title":"Disseminated tuberculosis of central nervous system: Spinal intramedullary and intracranial tuberculomas","author":"Lim","year":"2013","journal-title":"J Korean Neurosurg Soc"},{"key":"key-10.4103\/1793-5482.185073-13","first-page":"177","volume-title":", Tsang VC, Nash TE, Takayanagui OM, et al. 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