{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:19:02Z","timestamp":1777792742487,"version":"3.51.4"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":1566,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>The role of isocitrate dehydrogenase 1 (IDH1) mutation in brain stem glioma is not clear. To the best of our knowledge, six cases of brain stem gliomas carrying IDH1\/2 mutations are currently reported in the literature. One case of diffuse brain stem glioma with IDH1 mutation, which was followed for 2 years, is presented and compared with IDH1 negative tumors. A 22-year-old lady was referred with diplopia and left arm palsy. Neuroimaging detected a nonenhancing, nonhomogeneous diffuse infiltrating brain stem tumor extending from pons to medulla. Microsurgical debulking was performed. Microscopic evaluation of the tissue specimen and immunohistochemistry revealed an astrocytoma WHO Grade II with proliferation rate of 3% and glial fibrillary acidic protein (GFAP)-positive tumor cells. Interestingly, the tumor cells expressed mutated IDH1 R132H protein. The patient underwent adjuvant radiation and chemotherapy. The primary and 2 years' clinical\/radiological characteristics did not indicate any significant difference from other cases without IDH1 mutation. the prognostic value of IDH1\/2 mutation in brain stem glioma is unclear. Brain stem biopsies may allow determination of a tissue-based tumor diagnosis for further investigations.<\/jats:p>","DOI":"10.4103\/1793-5482.228540","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T11:26:49Z","timestamp":1522150009000},"page":"414-417","source":"Crossref","is-referenced-by-count":13,"title":["IDH1 mutation in brain stem glioma: Case report and review of literature"],"prefix":"10.1055","volume":"13","author":[{"given":"Seyed","family":"Javadi","sequence":"additional","affiliation":[{"name":"Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Neurosurgery, International Neuroscience Institute, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Hannover Medical School (MHH), Institute of Pathology, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, International Neuroscience Institute, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roozbeh","family":"Banan","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Hannover Medical School (MHH), Institute of Pathology, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Samii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, International Neuroscience Institute, Hannover"},{"name":"Department of Neurosurgery, International Neuroscience Institute, Hannover; Leibniz Institute for Neurobiology, Magdeburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"key-10.4103\/1793-5482.228540-1","first-page":"2528","volume-title":"Brainstem gliomas in adults: Prognostic factors and classification","author":"Guillamo","year":"2001","journal-title":"Brain"},{"key":"key-10.4103\/1793-5482.228540-2","first-page":"97","volume-title":"The 2007 WHO classification of tumours of the central nervous system","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"key-10.4103\/1793-5482.228540-3","first-page":"469","volume-title":"Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas","author":"Hartmann","year":"2009","journal-title":"Acta Neuropathol"},{"key":"key-10.4103\/1793-5482.228540-4","first-page":"74","volume-title":"The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations","author":"von","year":"2011","journal-title":"Brain Pathol"},{"key":"key-10.4103\/1793-5482.228540-5","first-page":"449","volume-title":"Low rate of R132H IDH1 mutation in infratentorial and spinal cord grade II and III diffuse gliomas","author":"Ellezam","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key-10.4103\/1793-5482.228540-6","first-page":"631","volume-title":"BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern","author":"Ida","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"key":"key-10.4103\/1793-5482.228540-7","first-page":"269","volume-title":"IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma","author":"SongTao","year":"2012","journal-title":"Cancer Sci"},{"key":"key-10.4103\/1793-5482.228540-8","first-page":"439","volume-title":"K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas","author":"Khuong-Quang","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key-10.4103\/1793-5482.228540-9","first-page":"1","volume-title":"Clinicopathological features of human brainstem gliomas","author":"Oka","year":"2013","journal-title":"Brain Tumor Pathol"},{"key":"key-10.4103\/1793-5482.228540-10","first-page":"405","volume-title":"Molecular analysis of diffuse intrinsic brainstem gliomas in adults","author":"Reyes-Botero","year":"2014","journal-title":"J Neurooncol"},{"key":"key-10.4103\/1793-5482.228540-11","first-page":"226","volume-title":"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma","author":"Schwartzentruber","year":"2012","journal-title":"Nature"},{"key":"key-10.4103\/1793-5482.228540-12","first-page":"251","volume-title":"Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas","author":"Wu","year":"2012","journal-title":"Nat Genet"},{"key":"key-10.4103\/1793-5482.228540-13","first-page":"599","volume-title":"Monoclonal antibody specific for IDH1 R132H mutation","author":"Capper","year":"2009","journal-title":"Acta Neuropathol"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1793-5482.228540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:37:03Z","timestamp":1663202223000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1793-5482.228540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":13,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,9,14]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.4103\/1793-5482.228540","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}