{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:25:56Z","timestamp":1751289956541},"reference-count":7,"publisher":"ScienceOpen","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The utility of a biological dosimeter based on the analysis of dicentrics is invaluable in the event of a radiological emergency wherein the estimated absorbed dose of an exposed individual is crucial in the proper medical management of patients. The technique is also used for routine monitoring of occupationally exposed workers to determine radiation exposure. An<jats:italic>in vitro<\/jats:italic>irradiation study of human peripheral blood lymphocytes was conducted to establish a dose-response curve for radiation-induced dicentric aberrations. Blood samples were collected from volunteer donors and together with optically stimulated luminescence (OSL) dosimeters and were irradiated at 0, 0.1, 0.25, 0.5, 0.75, 1, 2, 4, and 6 Gy using a cobalt-60 radiotherapy unit. Blood samples were cultured for 48 h, and the metaphase chromosomes were prepared following the procedure of the International Atomic Energy Agency's Emergency Preparedness and Response \u2013 Biodosimetry 2011 manual. At least 100 metaphases were scored for dicentric aberrations at each dose point. The data were analyzed using R language program. The results indicated that the distribution of dicentric cells followed a Poisson distribution and the dose-response curve was established using the estimated model,<jats:italic>Y<\/jats:italic><jats:sub>dic<\/jats:sub>= 0.0003 (\u00b10.0003) +0.0336 (\u00b10.0115) \u00d7<jats:italic>D<\/jats:italic>+ 0.0236 (\u00b10.0054) \u00d7<jats:italic>D<\/jats:italic><jats:sup>2<\/jats:sup>. In this study, the reliability of the dose-response curve in estimating the absorbed dose was also validated for 2 and 4 Gy using OSL dosimeters. The data were fitted into the constructed curve. The result of the validation study showed that the obtained estimate for the absorbed exposure doses was close to the true exposure doses.<\/jats:p>","DOI":"10.4103\/2041-9414.197163","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T06:31:04Z","timestamp":1483079464000},"source":"Crossref","is-referenced-by-count":4,"title":["Enhancing Cytogenetic Biological Dosimetry Capabilities of the Philippines for Nuclear Incident Preparedness"],"prefix":"10.14293","volume":"7","author":[{"given":"Celia O.","family":"Asaad","sequence":"first","affiliation":[{"name":"Department of Science and Technology, Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Commonwealth Avenue, Diliman, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloriamaris L.","family":"Caraos","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Commonwealth Avenue, Diliman, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo Jose M.","family":"Robles","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Commonwealth Avenue, Diliman, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anie Day D. C.","family":"Asa","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Commonwealth Avenue, Diliman, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lucia C.","family":"Cobar","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Commonwealth Avenue, Diliman, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al-Ahmadgaid","family":"Asaad","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Commonwealth Avenue, Diliman, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5403","published-online":{"date-parts":[[2016]]},"reference":[{"key":"ref1","volume-title":"IAEA EPR-Biodosimetry 2011. 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R: A Language and Environment for Statistical Computing"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e114137","DOI":"10.1371\/journal.pone.0114137","article-title":"A new model of biodosimetry to integrate low and high doses","volume":"9","author":"M Pujol","year":"2014","journal-title":"PLoS One"},{"key":"ref6","article-title":"Biological dosimetry of iononizing radiation","author":"A Vaurijoux","year":"2012"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/biomet\/46.3-4.441","article-title":"Confidence intervals for the expectation of a poisson variable","volume":"46","author":"EL Crow","year":"1959","journal-title":"Biometrika Trust"}],"container-title":["Genome Integrity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scienceopen.com\/document_file\/9c2c200e-b707-469d-a1ac-08ab85c6ae8a\/ScienceOpen\/9c2c200e-b707-469d-a1ac-08ab85c6ae8a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T14:01:05Z","timestamp":1718978465000},"score":1,"resource":{"primary":{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":7,"URL":"https:\/\/doi.org\/10.4103\/2041-9414.197163","relation":{},"ISSN":["2041-9414"],"issn-type":[{"value":"2041-9414","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016]]},"published":{"date-parts":[[2016]]}}}