{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:34:42Z","timestamp":1774593282711,"version":"3.50.1"},"reference-count":12,"publisher":"ScienceOpen","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Three <jats:italic>in vitro<\/jats:italic> dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure to ionizing radiation. Peripheral blood lymphocyte samples obtained from healthy donors were irradiated with <jats:sup>60<\/jats:sup>Co source at a dose rate of 0.5 Gy\/min to doses of 0.1\u20136 Gy. The results from three <jats:italic>in vitro<\/jats:italic> dose calibration curves for biodosimetry were analyzed to understand the relationship among biodosimetry assay techniques. Our comparison demonstrates that there is a very strong positive correlation among the dicentric assay, FISH, and MNs analysis, and these three biodosimetry assays strongly support the <jats:italic>in vitro<\/jats:italic> dose reconstruction and the emergency preparedness of public or occupational radiation overexposure.<\/jats:p>","DOI":"10.4103\/2041-9414.197168","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T06:31:04Z","timestamp":1483079464000},"source":"Crossref","is-referenced-by-count":10,"title":["Strong Correlation among Three Biodosimetry Techniques Following Exposures to Ionizing Radiation"],"prefix":"10.14293","volume":"7","author":[{"given":"Chang-Mo","family":"Kang","sequence":"first","affiliation":[{"name":"Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jin","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Kim","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co., Gyeonggi-do 13605, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cha Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, Radiation Health Institute, Korea Hydro and Nuclear Power Co., Gyeonggi-do 13605, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5403","published-online":{"date-parts":[[2016]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/HP.0b013e3181c4b9c1","article-title":"Follow-up study by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to 60Co radiation","volume":"98","author":"Q Liu","year":"2010","journal-title":"Health Phys"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1667\/RR2321.1","article-title":"Biological dosimetry by the triage dicentric chromosome assay: Potential implications for treatment of acute radiation syndrome in radiological mass casualties","volume":"175","author":"H Romm","year":"2011","journal-title":"Radiat Res"},{"key":"ref3","volume-title":"International Atomic Energy Agency. 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IAEA Technical Report Series, No. 405","year":"2001"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/mutage\/4.2.98","article-title":"Kinetochore detection in micronuclei: An alternative method for measuring chromosome loss","volume":"4","author":"M Fenech","year":"1989","journal-title":"Mutagenesis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/09553000902751462","article-title":"Spontaneous frequency of micronuclei among the newborns from high level natural radiation areas of Kerala in the Southwest Coast of India","volume":"85","author":"B Das","year":"2009","journal-title":"Int J Radiat Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1667\/RR1552.1","article-title":"Radiation dose prediction using data on time to emesis in the case of nuclear terrorism","volume":"171","author":"E Demidenko","year":"2009","journal-title":"Radiat Res"},{"key":"ref8","first-page":"719","article-title":"Frequency of micronuclei in X-irradiated human lymphocytes","volume":"49","author":"Z Almassy","year":"1986","journal-title":"Int J Radiat Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0165-7992(88)90008-5","article-title":"A comment on the quantitative relationship between micronuclei and chromosomal aberrations","volume":"207","author":"JR Savage","year":"1988","journal-title":"Mutat Res"},{"key":"ref10","first-page":"231","article-title":"Dose estimation with the calibration of dose-response curve of micronucleus in human peripheral lymphocytes induced by 50MeV proton beams","volume":"8","author":"YJ Go","year":"2011","journal-title":"Iran J Radiat Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2203\/dose-response.13-060.Selvan","article-title":"Delayed mitogenic stimulation decreases DNA damage assessed by micronucleus assay in human peripheral blood lymphocytes after (60) co irradiation","volume":"12","author":"GT Selvan","year":"2014","journal-title":"Dose Response"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/09553000903264481","article-title":"Automated micronucleus (MN) scoring for population triage in case of large scale radiation events","volume":"86","author":"P Willems","year":"2010","journal-title":"Int J Radiat Biol"}],"container-title":["Genome Integrity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scienceopen.com\/document_file\/de5b3f60-e6c0-453f-950a-833ec2188d03\/ScienceOpen\/de5b3f60-e6c0-453f-950a-833ec2188d03.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:08:42Z","timestamp":1694776122000},"score":1,"resource":{"primary":{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":12,"URL":"https:\/\/doi.org\/10.4103\/2041-9414.197168","relation":{},"ISSN":["2041-9414"],"issn-type":[{"value":"2041-9414","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016]]},"published":{"date-parts":[[2016]]}}}