{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:12:11Z","timestamp":1784873531232,"version":"3.55.0"},"reference-count":16,"publisher":"ScienceOpen","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>To develop a calibration curve for induction of dicentric chromosomes by radiation, we have used a 60Co gamma-ray source with dose rate of 12.5 mGy\/s. Whole blood from 15 healthy donors was collected. Whole blood from each donor was divided equally into 8 parts for exposing to supposedly physical doses 0, 0.30, 0.50, 1.00, 1.50, 2.00, 3.00 and 4.00 Gy for a independent calibration curve. Whole blood from 15 donors was used to calibrate dose \u2013 effect and statistical for general calibration curve. Using Poisson test (U-test) for the distribution of dicentric chromosomes in the metaphases to determine the uniformity of the radiation field. The average from 15 independent calibration curves of linear correlated coefficient was determined to be <jats:italic>r<\/jats:italic> (y, d) = 0.5136 \u00b1 0.0038. The model equation derived is y = aD + bD<jats:sup>2<\/jats:sup> + C. The calibration equation of dose-effect was y = 1.01D + 4.43D<jats:sup>2<\/jats:sup> + 0.56.<\/jats:p>","DOI":"10.4103\/2041-9414.197171","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T06:31:04Z","timestamp":1483079464000},"source":"Crossref","is-referenced-by-count":2,"title":["Calibration Curve for Dicentric Chromosomes Induced in Human Blood Lymphocytes Exposed to Gamma Rays at a Dose Rate of 12.5 mGy\/s"],"prefix":"10.14293","volume":"7","author":[{"given":"Tran","family":"Que","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Biodosimetry Section, Nuclear Research Institute, Vietnam Atomic Energy Commission, VINATOM, Dalat, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Ngoc","family":"Duy","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biodosimetry Section, Nuclear Research Institute, Vietnam Atomic Energy Commission, VINATOM, Dalat, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui Thi Kim","family":"Luyen","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biodosimetry Section, Nuclear Research Institute, Vietnam Atomic Energy Commission, VINATOM, Dalat, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5403","published-online":{"date-parts":[[2016]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/jmg.13.2.103","article-title":"Classification and relationships of induced chromosomal structual changes","volume":"13","author":"JR Savage","year":"1976","journal-title":"J Med Genet"},{"key":"ref2","volume-title":"IAEA 1986: Biological Dosimetry: Chromosomal Aberration Analysis for Dose Assessment. Technical Reports Series No.260","year":"1986"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0165-1110(88)90017-6","article-title":"Current status of cytogenetic procedures to detect and quantify previous exposures to radiation","volume":"196","author":"MA Bender","year":"1988","journal-title":"Mutat Res"},{"key":"ref4","volume-title":"IAEA 2001: Biological Dosimetry: Cytogenetic Analysis for Radiation Dose Assessment, A Manual. Technical Reports Series No. 405","year":"2001"},{"key":"ref5","first-page":"251","article-title":"Cytogenetic damage analysed by the dicentric assay","volume":"45","author":"H Romm","year":"2009","journal-title":"Ann Ist Super Sanita"},{"key":"ref6","volume-title":"IAEA 2011: Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Co-sponsored by IAEA and WHO, EPR-biodosimetry 2011","year":"2011"},{"key":"ref7","volume-title":"Statistic Methods for Biological Dosimetry, Health Protection Agency, HPA-RPD-011","author":"M Szluinska","year":"2005"},{"key":"ref8","first-page":"75","year":"1990","journal-title":"Edwards AA: Dosimetric and statistical aspects of cytogenetics. I reunion internacional sobre dosimetria biologica. Empresa Nacional de Residuos Radioactivos, Madrid"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2307\/3578074","article-title":"An appraisal of the value of the contaminated Poisson method to estimate the dose inhomogeneity in simulated partial-body exposure","volume":"128","author":"A Hilali","year":"1991","journal-title":"Radiat Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.radmeas.2011.03.012","article-title":"Biological dosimetry by the triage dicentric chromosome assay \u2013 Further validation of International Networking","volume":"46","author":"RC Wilkins","year":"2011","journal-title":"Radiat Meas"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2307\/3576677","article-title":"Induction of chromosome aberrations in G0 human lymphocytes by low doses of ionizing radiations of different quality","volume":"103","author":"L Fabry","year":"1985","journal-title":"Radiat Res"},{"key":"ref12","first-page":"23","article-title":"Chromosome aberrations in human lymphocytes: Effect of radiation quality, dose, and dose rate In:Radiation-induced Chromosome Damage in Man","author":"DC Lloyd","year":"1983"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1269\/jrr.33.SUPPLEMENT_44","article-title":"Cytogenetic biomonitoring of human radiation exposures: Possibilities, problems and pitfalls","volume":"33","author":"MS Sasaki","year":"1992","journal-title":"J Radiat Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01323712","article-title":"Quantitative analysis of the chromosome damage at first division of human lymphocytes after 60-Co gamma irradiation","volume":"22","author":"M Bauchinger","year":"1983","journal-title":"Radiat Environ Biophys"},{"key":"ref15","article-title":"Biodosimetry Intercomparison: FOI and DRDC Ottawa. FOI-R-1929-SE","author":"D Stricklin","year":"2006","journal-title":"Scientific Report, NBC Defence"},{"key":"ref16","first-page":"2","article-title":"AFRRI's Gamma-Ray, X-Ray, and Fission-Neutron Calibration Curves for the Lymphocyte Dicentric Assay: Application of a Metaphase Finder System.8901 Wisconsin Avenue, Bethesda, Maryland 20889-5603: Armed Forces Radiobiology Research Institute, Special Publication; 2002","author":"PG Prasanna"}],"container-title":["Genome Integrity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scienceopen.com\/document_file\/2b69ca17-fb65-4a15-8283-a04c4e670f15\/ScienceOpen\/2b69ca17-fb65-4a15-8283-a04c4e670f15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:07:29Z","timestamp":1694776049000},"score":1,"resource":{"primary":{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":16,"URL":"https:\/\/doi.org\/10.4103\/2041-9414.197171","relation":{},"ISSN":["2041-9414"],"issn-type":[{"value":"2041-9414","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016]]},"published":{"date-parts":[[2016]]}}}