{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:34:46Z","timestamp":1774593286239,"version":"3.50.1"},"reference-count":9,"publisher":"ScienceOpen","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Biological dosimetry using chromosome aberration analyses in human peripheral blood lymphocytes is suitable and useful tool for estimating the dose when a nuclear or radiological emergency is investigated. Blood samples from five healthy donors were obtained to establish dose-response calibration curves for chromosomal aberrations after exposure to ionizing radiation. In this work, dicentric assay and CBMN assay were compared considering the sensitivity and accuracy of dose estimation. In a total of 21,688 analyzed metaphase spreads, 10,969 dicentric chromosomes, 563 centric rings and 11,364 acentric chromosomes were found. The number of metaphase cells decreased with increasing radiation dose. The centric rings were not found in the non-irradiated control. There was no relationship between radiation dose and acentric ring induction. The frequency of total MN increased in a dose-dependent manner. In comparison with the control value, MN increased about 9, 32, 75, 87, and 52 fold higher after treatment with 1, 2, 3, 4, and 5 Gy, respectively. The results revealed that the mean frequency of chromosomal aberrations, both in dicentric and in micronuclei analyses increased with increasing radiation dose.<\/jats:p>","DOI":"10.4103\/2041-9414.197172","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T06:31:04Z","timestamp":1483079464000},"source":"Crossref","is-referenced-by-count":12,"title":["Chromosomal Aberrations in Human Peripheral Blood Lymphocytes after Exposure to Ionizing Radiation"],"prefix":"10.14293","volume":"7","author":[{"given":"Tae Ho","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Radiation Biotechnology, Korea Atomic Energy Research Institute, Jeongup 56212, Korea"},{"name":"Department of Biotechnology, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Biotechnology, Korea Atomic Energy Research Institute, Jeongup 56212, Korea"},{"name":"Department of Radiation Biotechnology and Applied Radioisotope Science, University of Science and Technology, Daejeon 34113, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Biotechnology, Korea Atomic Energy Research Institute, Jeongup 56212, Korea"},{"name":"Department of Radiation Biotechnology and Applied Radioisotope Science, University of Science and Technology, Daejeon 34113, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5403","published-online":{"date-parts":[[2016]]},"reference":[{"key":"ref1","author":"RC Ricks","year":"2000","journal-title":"REAC\/TS Radiation Accident Registry: Update of Accidents in the United States"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1586\/14737159.1.2.211","article-title":"Biological indicators for the identification of ionizing radiation exposure in humans","volume":"1","author":"SA Amundson","year":"2001","journal-title":"Expert Rev Mol Diagn"},{"key":"ref3","first-page":"307","article-title":"Biodosimetric tools for a fast triage of people accidentally exposed to ionising radiation. Statistical and computational aspects","volume":"45","author":"EA Ainsbury","year":"2009","journal-title":"Ann Ist Super Sanita"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/rpd\/ncl109","article-title":"Biodosimetry using chromosome aberrations in human lymphocytes","volume":"123","author":"S Senthamizhchelvan","year":"2007","journal-title":"Radiat Prot Dosimetry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1073\/pnas.48.4.522","article-title":"Types and rates of x-ray-induced chromosome aberrations in human blood irradiated in vitro","volume":"48","author":"MA Bender","year":"1962","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrgentox.2013.06.021","article-title":"Rapid assessment of high-dose radiation exposures through scoring of cell-fusion-induced premature chromosome condensation and ring chromosomes","volume":"757","author":"AI Lamadrid Boada","year":"2013","journal-title":"Mutat Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1383-5718(02)00067-0","article-title":"Chromosome aberrations induced in human lymphocytes by in vitro and in vivo x-rays","volume":"517","author":"H Schr\u00f6der","year":"2002","journal-title":"Mutat Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0027-5107(98)00100-6","article-title":"Micronuclei-biological indicator for retrospective dosimetry after exposure to ionizing radiation","volume":"404","author":"C Streffer","year":"1998","journal-title":"Mutat Res"},{"key":"ref9","year":"2011","journal-title":"International Atomic Energy Agency. Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Vienna; International Atomic Energy Agency"}],"container-title":["Genome Integrity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/scienceopen.com\/document_file\/2871731d-d8b3-4143-9446-07afc90dc8f0\/ScienceOpen\/2871731d-d8b3-4143-9446-07afc90dc8f0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:07:49Z","timestamp":1694776069000},"score":1,"resource":{"primary":{"URL":"https:\/\/scienceopen.com\/hosted-document?doi=10.4103\/2041-9414.197172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":9,"URL":"https:\/\/doi.org\/10.4103\/2041-9414.197172","relation":{},"ISSN":["2041-9414"],"issn-type":[{"value":"2041-9414","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016]]},"published":{"date-parts":[[2016]]}}}