{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:07:05Z","timestamp":1791295625482,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Pulmonary hypertension (PH) is defined as a resting mean pulmonary artery pressure greater than 25\u00a0mmHg. The World Health Organization (WHO) classifies PH into five categories. The WHO nomenclature assumes shared histology and pathophysiology within categories and implies category\u2010specific treatment. Imaging of the heart and pulmonary vasculature is critical to assigning a patient's PH syndrome to the correct WHO category and is also important in predicting outcomes. Imaging studies often reveal that the etiology of PH in a patient reflects contributions from several categories. Overlap between Categories 2 and 3 (left heart disease and lung disease) is particularly common, reflecting shared risk factors. Correct classification of PH patients requires the combination of standard imaging (chest roentgenograms, ventilation\u2010perfusion scans, echocardiography, and the 12\u2010lead electrocardiogram) and advanced imaging (computed tomography, cardiac magnetic resonance imaging, and positron emission tomography). Despite the value of imaging, cardiac catheterization remains the gold standard for quantification of hemodynamics and is required before initiation of PH\u2010specific therapy. These cases illustrate the use of imaging in classifying patients into WHO PH Categories 1\u20135.<\/jats:p>","DOI":"10.4103\/2045-8932.94843","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T15:04:48Z","timestamp":1333983888000},"page":"107-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["The WHO Classification of Pulmonary Hypertension: A Case\u2010Based Imaging Compendium"],"prefix":"10.1002","volume":"2","author":[{"given":"John J.","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Cardiology Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thenappan","family":"Thenappan","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Cardiology Illinois 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