{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:52:22Z","timestamp":1791917542411,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Gas Res"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/2045-9912.241078","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T03:54:18Z","timestamp":1537847658000},"page":"121","source":"Crossref","is-referenced-by-count":23,"title":["Ozone therapy as a primary and sole treatment for acute bacterial infection: case report"],"prefix":"10.4103","volume":"8","author":[{"given":"RobertJay","family":"Rowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2045-9912.241078-1","volume-title":"The End of the Antibiotic Era: What You Need to Know About Bacterial Resistance.","author":"Sainato","journal-title":"com\/"},{"key":"key-10.4103\/2045-9912.241078-2","first-page":"161","volume-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.Lancet Infect Dis","author":"Liu","year":"2016","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-3","first-page":"2149","volume-title":"Infectious Disease Mortality Trends in the United States, 1980-2014.JAMA","author":"Hansen","year":"2016","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-4","unstructured":"Branswell H. Woman Killed by a Superbug Resistant to Every Available Antibiotic. The \u201cnightmare bacteria\u201d could fend off 26 different drugs.https:\/\/www.scientificamerican.com\/article\/woman-killed-by-a-superbug-resistant-to-every-available-antibiotic\/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciam%2Fhealth-and-medicine+ (Topic%3A+Health)."},{"key":"key-10.4103\/2045-9912.241078-5","first-page":"277","volume-title":"The antibiotic resistance crisis: part 1: causes and threats.P T","author":"Ventola","year":"2015","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-6","unstructured":"Pesheva E. A cinematic approach to drug resistance.http:\/\/news.harvard.edu\/gazette\/story\/2016\/09\/a-cinematic-approach-to-drug-resistance\/."},{"key":"key-10.4103\/2045-9912.241078-7","first-page":"1193","volume-title":"Antimicrobial Resistance.JAMA","author":"Marston","year":"2016","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-8","first-page":"66","volume-title":"Ozone therapy: A clinical review.J Nat Sci Biol Med","author":"Elvis","year":"2011","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-9","unstructured":"Bocci V. A New Medical Drug 2nd ed. Netherands: Springer; 2011."},{"key":"key-10.4103\/2045-9912.241078-10","unstructured":"Menendez S, Weiser M. Advances of Ozone Therapy in Medicine and Dentistry. 2016; Havana, Cuba."},{"key":"key-10.4103\/2045-9912.241078-11","first-page":"23","volume-title":"Efficiency of tazobactam\/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3\/O2-pneumoperitoneum.Shock","author":"Bette","year":"2006","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-12","first-page":"371","volume-title":"Preconditioning with ozone\/oxygen mixture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis.Inflamm Res","author":"Rodr\u00edguez","year":"2009","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-13","first-page":"16","volume-title":"Effects of Ozone Oxidative Preconditioning on TNF-\u03b1 Release and Antioxidant-Prooxidant Intracellular Balance in Mice During Endotoxic Shock.Mediators Inflamm","author":"Zamora","year":"2005","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-14","unstructured":"Leusink J, Kraft G. Antimicrobial Effects of Ozonated Water Against Generic E.coli on Swine Intestines Varying Ozone Concentrations and Exposure Times.https:\/\/www.ozonesolutions.com\/files\/research\/ecoli_swine_intestines.pdf."},{"key":"key-10.4103\/2045-9912.241078-15","unstructured":"Fact Sheet Disinfection Using Chlorine Bleach. http:\/\/www.environize.ca\/wp-content\/themes\/Environize\/images\/chlorine-fact-sheet.pdf."},{"key":"key-10.4103\/2045-9912.241078-16","first-page":"599","volume-title":"The respiratory burst of phagocytes.J Clin Invest","author":"Babior","year":"1984","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-17","first-page":"3031","volume-title":"Investigating antibody-catalyzed ozone generation by human neutrophils.Proc Natl Acad Sci USA","author":"Babior","year":"2003","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-18","unstructured":"Jacobs M. Zwischenfa?lle und typische Komplikationen in der Ozon- Sauerstoff-Therapie. Naturheilpraxis. 1982;3:444."},{"key":"key-10.4103\/2045-9912.241078-19","first-page":"7","volume-title":"Regelsberger\u2019s intravenous oxygen therapy--an interpretation of results in practice from a biochemical and physiological point of view.Forsch Komplementarmed Klass Naturheilkd","author":"Schmidt","year":"2002","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-20","first-page":"211","volume-title":"Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease.Prostaglandins Leukot Essent Fatty Acids","author":"Stichtenoth","year":"2001","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-21","unstructured":"Kief H. Private Communication. 2016."},{"key":"key-10.4103\/2045-9912.241078-22","first-page":"271","volume-title":"Impact of intravenous oxygen therapy on the expression of reticulocyte-type 15-lipoxygenase in human volunteers.Prostaglandins Leukot Essent Fatty Acids","author":"Chaitidis","year":"2004","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-23","first-page":"1","volume-title":"The role of bacterial biofilms in chronic infections.APMIS Suppl","author":"Bjarnsholt","year":"2013","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-24","first-page":"BR339","volume-title":"Activity of ozonated water and ozone against Staphylococcus aureus and Pseudomonas aeruginosa biofilms.Med Sci Monit","author":"Bialoszewski","year":"2011","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-25","unstructured":"https:\/\/www.cdc.gov\/lyme\/signs_symptoms\/."},{"key":"key-10.4103\/2045-9912.241078-26","first-page":"2085, 2387","volume-title":"Cellulitis, headache, and fever following tick bites.J Clin Microbiol","author":"Junkins","year":"2011","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-27","first-page":"49","volume-title":"Rapid Resolution of Hemorrhagic Fever (Ebola) in Sierra Leone with Ozone Therapy.Afr J Infect Dis","author":"Rowen","year":"2016","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-28","doi-asserted-by":"crossref","unstructured":"Goodwin JS, Goodwin JM. The tomato effect. Rejection of highly efficacious therapies. JAMA. 1984;251:2387-2390.","DOI":"10.1001\/jama.1984.03340420053025"},{"key":"key-10.4103\/2045-9912.241078-29","first-page":"67","volume-title":"Ozone therapy in conjunction with oral antibiotics as a successful primary and sole treatment for chronic septic prosthetic joint: review and case report.Med Gas Res","author":"Rowen","year":"2018","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-30","first-page":"131S","volume-title":"Hyperbaric oxygen: its mechanisms and efficacy.Plast Reconstr Surg","author":"Thom","year":"2011","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-31","first-page":"432","volume-title":"Influenzal pneumonia: the intravenous injection of hydrogen peroxide.Lancet","author":"Oliver","year":"1920","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-32","first-page":"154","volume-title":"High Dose Intraveneous Vitamin C and Chikungunya Fever: A Case Report.J Orthomol Med","author":"Gonzalez","year":"2014","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-33","first-page":"20","volume-title":"Intravenous ascorbic acid and hydrogen peroxide in the management of patients with chikungunya.Bol Asoc Med P R","author":"Marcial-Vega","year":"2015","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-34","first-page":"486","volume-title":"Ultraviolet blood irradiation therapy; further studies in acute infections.Am J Surg","author":"Miley","year":"1947","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-35","first-page":"101","volume-title":"Massive doses of vitamin C and the virus diseases.South Med Surg","author":"Klenner","year":"1951","journal-title":""},{"key":"key-10.4103\/2045-9912.241078-36","first-page":"13604","volume-title":"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.Proc Natl Acad Sci U S A","author":"Chen","year":"2005","journal-title":""}],"container-title":["Medical Gas Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:38:15Z","timestamp":1786732695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2045-9912.241078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"alternative-id":["241078"],"URL":"https:\/\/doi.org\/10.4103\/2045-9912.241078","relation":{},"ISSN":["2045-9912"],"issn-type":[{"value":"2045-9912","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}