{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:31Z","timestamp":1787758051702,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Bacterial cystitis is a common clinical problem among cats and dogs and is one of the main reasons for the administration of antimicrobials. This can cause serious damage to public and animal health, as this practice facilitates the selection of bacteria that are multidrug-resistant to antibiotics. In this context, it is urgent to understand and validate therapeutic modalities that complement antimicrobial treatment in cystitis cases. Ozone therapy has been proposed by scientists owing to the various mechanisms of action in a range of pathologies, both in human and animal medicine. This paper describes the bactericidal action of two different protocols of bladder irrigation with ozonized saline solution (59 \u03bcg\/mL) in a paraplegic canine with recurrent bacterial cystitis caused by\n                      <jats:italic toggle=\"yes\">Proteus<\/jats:italic>\n                      spp. In the first protocol, the bladder instillations were applied once a day for three consecutive days while in the second, successive lavages were performed throughout the day until a significant reduction in the presence of bacteria in the urine sediment. In this study, we were able to demonstrate that repeated bladder instillation within 24 hours was the most effective treatment for\n                      <jats:italic toggle=\"yes\">Proteus<\/jats:italic>\n                      compared to a single instillation on successive days.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2045-9912.350861","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T05:00:55Z","timestamp":1657688455000},"page":"155-158","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of ozonized saline solution in the treatment of Proteus spp. bacterial cystitis"],"prefix":"10.4103","volume":"13","author":[{"given":"Ana 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