{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:44Z","timestamp":1787758304535,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We aimed to assess whether ropivacaine (0.75%; 22.5 mg) can replace bupivacaine (0.5%; 15 mg) as a better intrathecal anesthetic in lower abdominal surgery. In this hospital-based, single-blind, randomized, prospective, comparative study, 100 patients of either sex, aged between 18 and 70 years, weighing 40-80 kg, with American Society of Anesthesiologists physical status 1 and 2, and undergoing lower abdominal surgery were randomly allocated into two groups to receive intrathecal isobaric bupivacaine 0.5% 3 mL (15 mg) or ropivacaine 0.75% 3 mL (22.5 mg). In the intraoperative period, the onset, efficacy, duration, and regression of sensory and motor blockade and the quality of anesthesia and hemodynamic effects were observed at regular intervals. The ropivacaine and bupivacaine groups were comparable for demographic parameters. The duration of onset of sensory and motor blocks was significantly shorter in the bupivacaine group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). In the ropivacaine group, a faster recovery from sensory block (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) and higher segmental height [thoracic (T)10 and T8] were achieved (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Bradycardia and hypotension were insignificant in the ropivacaine group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). Isobaric ropivacaine is a better spinal anesthetic in lower abdominal surgeries as it provides faster recovery from sensory block and a higher level of segmental sensory block with fewer side-effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2045-9912.359678","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T05:56:37Z","timestamp":1666677397000},"page":"123-127","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Isobaric forms of ropivacaine vs. bupivacaine in lower abdominal surgeries"],"prefix":"10.4103","volume":"13","author":[{"given":"Pavitra","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Vithal","family":"Dhulkhed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vithal K.","family":"Dhulkhed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240907","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1213\/01.ane.0000281908.48784.91","article-title":"Transient neurological symptoms after isobaric subarachnoid anesthesia with 2% lidocaine: the impact of needle type","volume":"105","author":"Evron","year":"2007","journal-title":"Anesth Analg"},{"key":"R2-6-20240907","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1586\/14737175.4.5.781","article-title":"Ropivacaine: a pharmacological review","volume":"4","author":"Hansen","year":"2004","journal-title":"Expert Rev Neurother"},{"key":"R3-6-20240907","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/bja\/78.5.507","article-title":"Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers","volume":"78","author":"Knudsen","year":"1997","journal-title":"Br J Anaesth"},{"key":"R5-6-20240907","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2165\/00003495-200060050-00007","article-title":"Ropivacaine: an update of its use in regional anaesthesia","volume":"60","author":"McClellan","year":"2000","journal-title":"Drugs"},{"key":"R6-6-20240907","first-page":"97","article-title":"Anesthesia for day care surgery","volume":"5","author":"Shetty","year":"2015","journal-title":"Nitte Univ J Health Sci"},{"key":"R7-6-20240907","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4103\/aer.AER_105_17","article-title":"A prospective comparative observational study of clinical efficacy of isobaric ropivacaine 0.75% with of isobaric bupivacaine 0.5% intrathecally in elective inguinal hernia repair surgeries","volume":"11","author":"Parekh","year":"2017","journal-title":"Anesth Essays Res"},{"key":"R8-6-20240907","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1213\/01.ANE.0000117147.56528.33","article-title":"The relative motor blocking potencies of intrathecal ropivacaine: effects of concentration","volume":"98","author":"Camorcia","year":"2004","journal-title":"Anesth Analg"},{"key":"R9-6-20240907","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1213\/01.ANE.0000132972.61498.F1","article-title":"A prospective, randomized, double-blind comparison of unilateral spinal anesthesia with hyperbaric bupivacaine, ropivacaine, or levobupivacaine for inguinal herniorrhaphy","volume":"99","author":"Casati","year":"2004","journal-title":"Anesth Analg"},{"key":"R10-6-20240907","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00000539-200107000-00031","article-title":"Hyperbaric spinal ropivacaine for cesarean delivery: a comparison to hyperbaric bupivacaine","volume":"93","author":"Chung","year":"2001","journal-title":"Anesth Analg"},{"key":"R11-6-20240907","first-page":"221","article-title":"Spinal ropivacaine or bupivacaine for cesarean delivery: a prospective, randomized, doubleblind comparison","volume":"29","author":"Danelli","year":"2004","journal-title":"Reg Anesth Pain Med"},{"key":"R12-6-20240907","first-page":"868","article-title":"Comparison between intrathecal isobaric bupivacaine 0.5% with isobaric ropivacaine 0.75% for lower limb orthopaedic surgeries: A double blind randomized controlled study","volume":"4","author":"Verma","year":"2017","journal-title":"Int J Contemp Med Res"},{"key":"R14-6-20240907","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4103\/0259-1162.123252","article-title":"Comparison of efficacy and safety of ropivacaine with bupivacaine for intrathecal anesthesia for lower abdominal and lower limb surgeries","volume":"7","author":"Bhat","year":"2013","journal-title":"Anesth Essays Res"},{"key":"R15-6-20240907","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/00000539-200012000-00030","article-title":"Intrathecal anesthesia: ropivacaine versus bupivacaine","volume":"91","author":"Malinovsky","year":"2000","journal-title":"Anesth Analg"},{"key":"R16-6-20240907","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jclinane.2006.03.006","article-title":"Comparison of ropivacaine and bupivacaine for intrathecal anesthesia during outpatient arthroscopic surgery","volume":"18","author":"Boztu\u011f","year":"2006","journal-title":"J Clin Anesth"},{"key":"R17-6-20240907","first-page":"65","article-title":"Spinal anesthesia: comparison of plain ropivacaine, bupivacaine and levobupivacaine for lower abdominal surgery","volume":"59","author":"Mantouvalou","year":"2008","journal-title":"Acta AnaesthesiolBelg"},{"key":"R18-6-20240907","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1213\/01.ANE.0000129976.26455.32","article-title":"A comparison of intrathecal plain solutions containing ropivacaine 20 or 15 mg versus bupivacaine 10 mg","volume":"99","author":"Kallio","year":"2004","journal-title":"Anesth Analg"},{"key":"R19-6-20240907","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4103\/aer.AER_135_18","article-title":"Comparison of the efficacy of intrathecal isobaric ropivacaine and bupivacaine in day care knee arthroscopy: a randomized controlled trial","volume":"12","author":"Kumar","year":"2018","journal-title":"Anesth Essays Res"},{"key":"R20-6-20240907","first-page":"251","article-title":"Intrathecal use of ropivacaine: a review","volume":"55","author":"Wille","year":"2004","journal-title":"Acta Anaesthesiol Belg"},{"key":"R21-6-20240907","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4103\/1658-354X.115326","article-title":"Comparative study of intrathecal hyperbaric versus isobaric ropivacaine: a randomized control trial","volume":"7","author":"Gupta","year":"2013","journal-title":"Saudi J Anaesth"}],"container-title":["Medical Gas Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/2045-9912.359678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:12:46Z","timestamp":1787757166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2045-9912.359678"}},"subtitle":["a hospital-based, prospective, comparative study"],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/2045-9912.359678","relation":{},"ISSN":["2045-9912"],"issn-type":[{"value":"2045-9912","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}