{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:50:02Z","timestamp":1791726602287,"version":"4.3.4"},"reference-count":94,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD), the most prevalent cause of dementia, is a progressive neurodegenerative condition that commences subtly and inexorably worsens over time. Despite considerable research, a specific drug that can fully cure or effectively halt the progression of AD remains elusive. Nitric oxide (NO), a crucial signaling molecule in the nervous system, is intimately associated with hallmark pathological changes in AD, such as amyloid-beta deposition and tau phosphorylation. Several therapeutic strategies for AD operate through the nitric oxide synthase\/NO system. However, the potential neurotoxicity of NO introduces an element of controversy regarding its therapeutic utility in AD. This review focuses on research findings concerning NO\u2019s role in experimental AD and its underlying mechanisms. Furthermore, we have proposed directions for future research based on our current comprehension of this critical area.<\/jats:p>","DOI":"10.4103\/2045-9912.385939","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T06:10:16Z","timestamp":1694844616000},"page":"186-191","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["The effects of nitric oxide in Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"14","author":[{"given":"Lingling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China"},{"name":"Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China"},{"name":"Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China"},{"name":"Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-3420","authenticated-orcid":false,"given":"Zongqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China"},{"name":"Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8512-8318","authenticated-orcid":false,"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China"},{"name":"Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province, China"},{"name":"Institute of Stroke Research, Soochow University, Suzhou, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,17]]},"reference":[{"key":"R1-20250529","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/1039856218762308","article-title":"Alzheimer's disease: clinical update on epidemiology, pathophysiology and diagnosis","volume":"26","author":"Eratne","year":"2018","journal-title":"Australas Psychiatry"},{"key":"R2-20250529","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.14506.1","article-title":"Current understanding of Alzheimer\u2019s disease diagnosis and treatment","volume":"7","author":"Weller","year":"2018","journal-title":"F1000Res"},{"key":"R3-20250529","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/bc.bc_13_17","article-title":"A focus on CXCR4 in Alzheimer\u2019s disease","volume":"3","author":"Li","year":"2017","journal-title":"Brain Circ"},{"key":"R4-20250529","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s12975-020-00847-4","article-title":"Cerebral small vessel disease influences hippocampal subfield atrophy in mild cognitive impairment","volume":"12","author":"Wong","year":"2021","journal-title":"Transl Stroke Res"},{"key":"R5-20250529","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/bc.BC_2_17","article-title":"Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats","volume":"4","author":"Huang","year":"2018","journal-title":"Brain Circ"},{"key":"R6-20250529","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3390\/cells11121885","article-title":"Innate immune cell death in neuroinflammation and Alzheimer's disease","volume":"11","author":"Rajesh","year":"2022","journal-title":"Cells"},{"key":"R7-20250529","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1146\/annurev-biochem-032620-104801","article-title":"Lipoproteins in the central nervous system: from biology to pathobiology","volume":"91","author":"Raulin","year":"2022","journal-title":"Annu Rev Biochem"},{"key":"R8-20250529","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s12975-021-00921-5","article-title":"Is cerebral amyloid-\u03b2 deposition related to post-stroke cognitive impairment?","volume":"12","author":"Ouyang","year":"2021","journal-title":"Transl Stroke Res"},{"key":"R9-20250529","doi-asserted-by":"crossref","first-page":"3806157","DOI":"10.1155\/2016\/3806157","article-title":"Getting to NO Alzheimer\u2019s disease: neuroprotection versus neurotoxicity mediated by nitric oxide","volume":"2016","author":"Balez","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"R10-20250529","first-page":"23","article-title":"Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine","volume":"3","author":"Katsuki","year":"1977","journal-title":"J Cyclic Nucleotide Res"},{"key":"R11-20250529","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"R12-20250529","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1016\/S0021-9258(19)89205-0","article-title":"Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms","volume":"261","author":"Ignarro","year":"1986","journal-title":"J Biol Chem"},{"key":"R13-20250529","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1020537506008","article-title":"Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide","volume":"19","year":"1999","journal-title":"Biosci Rep"},{"key":"R14-20250529","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s12975-019-00767-y","article-title":"Short-term acute exercise preconditioning reduces neurovascular injury after stroke through induced eNOS activation","volume":"11","author":"Hafez","year":"2020","journal-title":"Transl Stroke Res"},{"key":"R15-20250529","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/bc.bc_69_20","article-title":"Clinical application of nitric oxide in ischemia and reperfusion injury: A literature review","volume":"6","author":"Jiang","year":"2020","journal-title":"Brain Circ"},{"key":"R16-20250529","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/bc.bc_3_21","article-title":"The influence of renal ischemia-reperfusion injury on remote organs: The histological brain changes in male and female rats","volume":"7","author":"Azarkish","year":"2021","journal-title":"Brain Circ"},{"key":"R17-20250529","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bbadis.2018.11.007","article-title":"Functions and dysfunctions of nitric oxide in brain","volume":"1865","author":"Pic\u00f3n-Pag\u00e8s","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"R18-20250529","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1177\/0271678X20983216","article-title":"Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage","volume":"41","author":"Mader","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"R19-20250529","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12975-016-0466-6","article-title":"Role of cyclooxygenase-2 in relation to nitric oxide and endothelin-1 on pathogenesis of cerebral vasospasm after subarachnoid hemorrhage in rabbit","volume":"7","author":"Munakata","year":"2016","journal-title":"Transl Stroke Res"},{"key":"R20-20250529","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1177\/0271678X20973787","article-title":"Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice","volume":"41","author":"Lenz","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"R21-20250529","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/2394-8108.178541","article-title":"Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: Regulatory mechanisms and therapeutic implications","volume":"2","author":"Iqbal","year":"2016","journal-title":"Brain Circ"},{"key":"R22-20250529","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12975-012-0217-2","article-title":"Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury","volume":"4","author":"Zhu","year":"2013","journal-title":"Transl Stroke Res"},{"key":"R23-20250529","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10571-019-00767-4","article-title":"Inflammatory pathways following subarachnoid hemorrhage","volume":"40","author":"Khey","year":"2020","journal-title":"Cell Mol Neurobiol"},{"key":"R24-20250529","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-021-02369-8","article-title":"Microbial pathogens induce neurodegeneration in Alzheimer\u2019s disease mice: protection by microglial regulation","volume":"19","author":"Ganz","year":"2022","journal-title":"J Neuroinflammation"},{"key":"R25-20250529","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3390\/biomedicines11051411","article-title":"The roles of the amyloid beta monomers in physiological and pathological conditions","volume":"11","author":"Schreiner","year":"2023","journal-title":"Biomedicines"},{"key":"R26-20250529","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13195-020-00629-y","article-title":"A decade of Alzheimer\u2019s research & therapy: reflections on the past, present, and future","volume":"12","author":"Galasko","year":"2020","journal-title":"Alzheimers Res Ther"},{"key":"R27-20250529","doi-asserted-by":"crossref","first-page":"e2219216120","DOI":"10.1073\/pnas.2219216120","article-title":"Probing differences among A\u03b2 oligomers with two triangular trimers derived from A\u03b2","volume":"120","author":"Kreutzer","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R28-20250529","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12551-023-01052-x","article-title":"Effect of \u03b2-amyloid on blood-brain barrier properties and function","volume":"15","author":"Petrushanko","year":"2023","journal-title":"Biophys Rev"},{"key":"R29-20250529","doi-asserted-by":"crossref","first-page":"124231","DOI":"10.1016\/j.ijbiomac.2023.124231","article-title":"A\u03b2-oligomers: A potential therapeutic target for Alzheimer\u2019s disease","volume":"239","author":"Ghosh","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"R30-20250529","doi-asserted-by":"crossref","first-page":"110019","DOI":"10.1016\/j.cbi.2022.110019","article-title":"\u03b3-Glutamylcysteine attenuates amyloid-\u03b2 oligomers-induced neuroinflammation in microglia via blocking NF-\u03baB signaling pathway","volume":"363","author":"Bi","year":"2022","journal-title":"Chem Biol Interact"},{"key":"R31-20250529","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/0271678X17734100","article-title":"Astrocytes drive cortical vasodilatory signaling by activating endothelial NMDA receptors","volume":"39","author":"Lu","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"R32-20250529","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1007\/s12035-022-02777-8","article-title":"CaMKII\u03b1 signaling is required for the neuroprotective effects of Dl-3-n-butylphthalide in Alzheimer\u2019s disease","volume":"59","author":"Li","year":"2022","journal-title":"Mol Neurobiol"},{"key":"R33-20250529","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/ijms20051242","article-title":"Increased iNOS and nitrosative stress in dopaminergic neurons of MDMA-exposed rats","volume":"20","author":"Schiavone","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R34-20250529","doi-asserted-by":"crossref","first-page":"7205747","DOI":"10.1155\/2016\/7205747","article-title":"Nitric oxide: exploring the contextual link with Alzheimer\u2019s disease","volume":"2016","author":"Asiimwe","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"R35-20250529","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/aps.2018.27","article-title":"Targeting RNS\/caveolin-1\/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery","volume":"39","author":"Chen","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"R36-20250529","doi-asserted-by":"crossref","first-page":"9029","DOI":"10.1007\/s12035-018-1027-7","article-title":"Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation","volume":"55","author":"Feng","year":"2018","journal-title":"Mol Neurobiol"},{"key":"R37-20250529","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.niox.2013.10.002","article-title":"Capacity of HSYA to inhibit nitrotyrosine formation induced by focal ischemic brain injury","volume":"35","author":"Sun","year":"2013","journal-title":"Nitric Oxide"},{"key":"R38-20250529","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/mas.21429","article-title":"Mass spectrometric analysis of protein tyrosine nitration in aging and neurodegenerative diseases","volume":"34","author":"Yeo","year":"2015","journal-title":"Mass Spectrom Rev"},{"key":"R39-20250529","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/antiox11050848","article-title":"Antioxidant and neuroprotective effects of carnosine: therapeutic implications in neurodegenerative diseases","volume":"11","author":"Solana-Manrique","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"R40-20250529","doi-asserted-by":"crossref","first-page":"E7564","DOI":"10.1073\/pnas.1608784113","article-title":"Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons","volume":"113","author":"Sunico","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R41-20250529","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/antiox9121203","article-title":"Peroxiredoxins in neurodegenerative diseases","volume":"9","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"R42-20250529","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/antiox6040077","article-title":"Procyanidin B2 protects neurons from oxidative, nitrosative, and excitotoxic stress","volume":"6","author":"Sutcliffe","year":"2017","journal-title":"Antioxidants (Basel)"},{"key":"R43-20250529","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.niox.2013.05.001","article-title":"Contribution of iNOS\/sGC\/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock","volume":"33","author":"Tunctan","year":"2013","journal-title":"Nitric Oxide"},{"key":"R44-20250529","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fncel.2015.00322","article-title":"Implications of glial nitric oxide in neurodegenerative diseases","volume":"9","author":"Yuste","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"R45-20250529","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0361-9230(03)00102-3","article-title":"Regulation of nitric oxide and soluble guanylyl cyclase","volume":"62","author":"Krumenacker","year":"2004","journal-title":"Brain Res Bull"},{"key":"R46-20250529","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1177\/0271678X19870583","article-title":"cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice","volume":"39","author":"Shvedova","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"R47-20250529","doi-asserted-by":"crossref","first-page":"17590914211035020","DOI":"10.1177\/17590914211035020","article-title":"Glycogen phosphorylase isoform regulation of ventromedial hypothalamic nucleus gluco-regulatory neuron 5'-AMP-activated protein kinase and transmitter marker protein expression","volume":"13","author":"Uddin","year":"2021","journal-title":"ASN Neuro"},{"key":"R48-20250529","doi-asserted-by":"crossref","first-page":"13853","DOI":"10.1021\/acs.jmedchem.1c01240","article-title":"Blood-brain barrier permeable and NO-releasing multifunctional nanoparticles for Alzheimer's disease treatment: targeting NO\/cGMP\/CREB signaling pathways","volume":"64","author":"Liu","year":"2021","journal-title":"J Med Chem"},{"key":"R49-20250529","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12640-015-9564-6","article-title":"Double-edged roles of nitric oxide signaling on APP processing and amyloid-\u03b2 production in vitro: preliminary evidence from sodium nitroprusside","volume":"29","author":"Cai","year":"2016","journal-title":"Neurotox Res"},{"key":"R50-20250529","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4155\/fmc.13.111","article-title":"Modulating nitric oxide signaling in the CNS for Alzheimer\u2019s disease therapy","volume":"5","year":"2013","journal-title":"Future Med Chem"},{"key":"R51-20250529","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1101\/lm.69204","article-title":"The cholinergic lesion of Alzheimer\u2019s disease: pivotal factor or side show?","volume":"11","year":"2004","journal-title":"Learn Mem"},{"issue":"Suppl 1","key":"R52-20250529","first-page":"3","article-title":"Strategies that support declining cholinergic neurotransmission in Alzheimer\u2019s disease patients","volume":"45","year":"1999","journal-title":"Gerontology"},{"key":"R53-20250529","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2174\/1567205053585945","article-title":"Nitric oxide mimetic molecules as therapeutic agents in Alzheimer\u2019s disease","volume":"2","author":"Thatcher","year":"2005","journal-title":"Curr Alzheimer Res"},{"key":"R54-20250529","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0022-3565(25)12295-7","article-title":"The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice","volume":"276","author":"Yamada","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"R55-20250529","doi-asserted-by":"crossref","first-page":"1125932","DOI":"10.3389\/fnmol.2023.1125932","article-title":"The role of ADAM17 in cerebrovascular and cognitive function in the APP\/PS1 mouse model of Alzheimer's disease","volume":"16","author":"Tian","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"R56-20250529","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1073\/pnas.89.1.444","article-title":"S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds","volume":"89","author":"Stamler","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R57-20250529","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1126\/science.1281928","article-title":"Biochemistry of nitric oxide and its redox-activated forms","volume":"258","author":"Stamler","year":"1992","journal-title":"Science"},{"key":"R58-20250529","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0092-8674(94)90269-0","article-title":"Redox signaling: nitrosylation and related target interactions of nitric oxide","volume":"78","year":"1994","journal-title":"Cell"},{"key":"R59-20250529","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/bs.mie.2019.08.004","article-title":"The roles of S-nitrosylation and S-glutathionylation in Alzheimer\u2019s disease","volume":"626","author":"Dyer","year":"2019","journal-title":"Methods Enzymol"},{"key":"R60-20250529","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1089\/ars.2010.3570","article-title":"S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases","volume":"14","author":"Nakamura","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"R61-20250529","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/jnc.14870","article-title":"Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer\u2019s disease","volume":"152","author":"Wijasa","year":"2020","journal-title":"J Neurochem"},{"key":"R62-20250529","first-page":"pe29","article-title":"Nitric oxide links mitochondrial fission to Alzheimer\u2019s disease","volume":"2","year":"2009","journal-title":"Sci Signal"},{"key":"R63-20250529","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1089\/ars.2021.0081","article-title":"Protein transnitrosylation signaling networks contribute to inflammaging and neurodegenerative disorders","volume":"35","author":"Nakamura","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"R64-20250529","doi-asserted-by":"crossref","first-page":"130032","DOI":"10.1016\/j.bbagen.2021.130032","article-title":"Products of S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase: relation between S-nitrosylation and oxidation","volume":"1866","author":"Schmalhausen","year":"2022","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"R65-20250529","doi-asserted-by":"crossref","first-page":"eaao6765","DOI":"10.1126\/scisignal.aao6765","article-title":"Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-\u03b2","volume":"11","author":"Sen","year":"2018","journal-title":"Sci Signal"},{"key":"R66-20250529","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.cell.2021.03.032","article-title":"Reducing acetylated tau is neuroprotective in brain injury","volume":"184","author":"Shin","year":"2021","journal-title":"Cell"},{"key":"R67-20250529","doi-asserted-by":"crossref","first-page":"129998","DOI":"10.1016\/j.bbagen.2021.129998","article-title":"Glucose-induced oxidative stress leads to in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells","volume":"1865","author":"Ogura","year":"2021","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"R68-20250529","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1007\/s11064-018-2589-5","article-title":"Neohesperidin prevents A\u03b2(25-35)-induced apoptosis in primary cultured hippocampal neurons by blocking the S-nitrosylation of protein-disulphide isomerase","volume":"43","author":"Wang","year":"2018","journal-title":"Neurochem Res"},{"key":"R69-20250529","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"R70-20250529","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mito.2010.04.007","article-title":"S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration","volume":"10","author":"Nakamura","year":"2010","journal-title":"Mitochondrion"},{"key":"R71-20250529","doi-asserted-by":"crossref","first-page":"14330","DOI":"10.1073\/pnas.1105172108","article-title":"S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide","volume":"108","author":"Qu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R72-20250529","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuint.2006.04.010","article-title":"Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms","volume":"49","author":"Pannu","year":"2006","journal-title":"Neurochem Int"},{"key":"R73-20250529","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/med.21636","article-title":"Inducible nitric oxide synthase inhibitors: A comprehensive update","volume":"40","author":"Minhas","year":"2020","journal-title":"Med Res Rev"},{"key":"R74-20250529","first-page":"212","article-title":"Antioxidants in Alzheimer\u2019s disease: current therapeutic significance and future prospects","volume":"11","author":"Pritam","year":"2022","journal-title":"Biology (Basel)"},{"key":"R75-20250529","article-title":"The four pillars of Alzheimer\u2019s prevention","author":"Khalsa","year":"2017","journal-title":"Cerebrum"},{"key":"R76-20250529","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1515\/revneuro-2021-0146","article-title":"Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases","volume":"33","author":"Gates","year":"2022","journal-title":"Rev Neurosci"},{"key":"R77-20250529","doi-asserted-by":"crossref","first-page":"113750","DOI":"10.1016\/j.bbr.2022.113750","article-title":"Nitric oxide impairs spatial learning and memory in a rat model of Alzheimer\u2019s disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning","volume":"422","author":"Ren","year":"2022","journal-title":"Behav Brain Res"},{"key":"R78-20250529","first-page":"211","article-title":"L-arginine and Alzheimer\u2019s disease","volume":"2","author":"Yi","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"R79-20250529","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.niox.2018.10.006","article-title":"Pharmacological manipulation of cGMP and NO\/cGMP in CNS drug discovery","volume":"82","author":"Hollas","year":"2019","journal-title":"Nitric Oxide"},{"key":"R80-20250529","doi-asserted-by":"crossref","first-page":"6784","DOI":"10.1021\/jm300353r","article-title":"Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy","volume":"55","author":"Qin","year":"2012","journal-title":"J Med Chem"},{"key":"R81-20250529","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1749-6632.1998.tb09911.x","article-title":"Age-associated memory impairment. Assessing the role of nitric oxide","volume":"854","author":"Meyer","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"R82-20250529","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0306-4522(98)00383-2","article-title":"Nitric oxide synthase neurons in different areas of normal aged and Alzheimer's brains","volume":"89","author":"Yew","year":"1999","journal-title":"Neuroscience"},{"key":"R83-20250529","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/jnc.12334","article-title":"Endothelial nitric oxide deficiency promotes Alzheimer\u2019s disease pathology","volume":"127","author":"Austin","year":"2013","journal-title":"J Neurochem"},{"key":"R84-20250529","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/0271678X18822474","article-title":"Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid","volume":"40","author":"Austin","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"R85-20250529","first-page":"179","article-title":"A reversal by L-arginine and sodium nitroprusside of ageing-induced memory impairment in rats by increasing nitric oxide concentration in the hippocampus","volume":"49","author":"Paul","year":"2005","journal-title":"Indian J Physiol Pharmacol"},{"key":"R86-20250529","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuro.2018.03.001","article-title":"Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer\u2019s disease in rats","volume":"66","author":"Dubey","year":"2018","journal-title":"Neurotoxicology"},{"key":"R87-20250529","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/156720506777632925","article-title":"NO chimeras as therapeutic agents in Alzheimer\u2019s disease","volume":"3","author":"Thatcher","year":"2006","journal-title":"Curr Alzheimer Res"},{"key":"R88-20250529","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1021\/acs.jmedchem.8b00389","article-title":"Furoxans (oxadiazole-4 n-oxides) with attenuated reactivity are neuroprotective, cross the blood brain barrier, and improve passive avoidance memory","volume":"61","author":"Horton","year":"2018","journal-title":"J Med Chem"},{"key":"R89-20250529","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neuron.2013.05.005","article-title":"Aberrant protein s-nitrosylation in neurodegenerative diseases","volume":"78","author":"Nakamura","year":"2013","journal-title":"Neuron"},{"key":"R90-20250529","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1742-2094-9-237","article-title":"SOD1 aggregation in astrocytes following ischemia\/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI)","volume":"9","author":"Chen","year":"2012","journal-title":"J Neuroinflammation"},{"key":"R91-20250529","doi-asserted-by":"crossref","first-page":"E3388","DOI":"10.1073\/pnas.1722452115","article-title":"S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy","volume":"115","author":"Rizza","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R92-20250529","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/15548627.2018.1475818","article-title":"Denitrosylate and live longer: how ADH5\/GSNOR links mitophagy to aging","volume":"14","author":"Rizza","year":"2018","journal-title":"Autophagy"},{"key":"R93-20250529","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3233\/JAD-121786","article-title":"Protective role of S-nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion","volume":"34","author":"Won","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"R94-20250529","doi-asserted-by":"crossref","first-page":"e12754","DOI":"10.1111\/acel.12754","article-title":"nNOS-CAPON interaction mediates amyloid-\u03b2-induced neurotoxicity, especially in the early stages","volume":"17","author":"Zhang","year":"2018","journal-title":"Aging Cell"}],"container-title":["Medical Gas Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/2045-9912.385939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:07:55Z","timestamp":1787774875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2045-9912.385939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,17]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/2045-9912.385939","relation":{},"ISSN":["2045-9912"],"issn-type":[{"value":"2045-9912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,17]]},"assertion":[{"value":"2022-03-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}