{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T20:41:47Z","timestamp":1650055307261},"reference-count":10,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Osteopetrosis is a rare congenital disorder of bone resorption, caused by failure of osteoclasts to reabsorb immature bone. Malignant infantile osteopetrosis presents in early life with generalized osteosclerosis and decreased bone marrow spaces, resulting in anemia, splenohepatomegaly due to extramedullary hematopoiesis, cranial nerve compression, and growth failure. It is a fatal condition with death occurring within the first year of life. Bone marrow transplant remains the only curative treatment. We present a report of an infant with splenohepatomegaly, who was diagnosed with malignant infantile osteopetrosis.<\/jats:p>","DOI":"10.4103\/2156-7514.139738","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T11:11:27Z","timestamp":1409224287000},"page":"48","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Infant with Splenohepatomegaly: A Rare Cause"],"prefix":"10.25259","volume":"4","author":[{"given":"Kathiravan","family":"Kalyanasundaram","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Podhini","family":"Jegadeesan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibi Chakravarthy","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinoth N","family":"Ponnurangam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2014,8,30]]},"reference":[{"key":"10.4103\/2156-7514.139738\/ref-1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajh.21447","article-title":"A single-center experience in 20 patients with infantile malignant osteopetrosis","volume":"84","author":"Mazzolari","year":"2009","journal-title":"Am J Hematol"},{"key":"10.4103\/2156-7514.139738\/ref-2","first-page":"69","article-title":"Malignant recessive osteopetrosis","volume":"36","author":"Phadke","year":"1999","journal-title":"Indian Pediatr"},{"key":"10.4103\/2156-7514.139738\/ref-3","first-page":"508","article-title":"Novel mutations in Indian patients with autosomal recessive infantile malignant osteopetrosis","volume":"131","author":"Phadke","year":"2010","journal-title":"Indian J Med Res"},{"key":"10.4103\/2156-7514.139738\/ref-4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/0971-6866.112911","article-title":"Malignant infantile osteopetrosis","volume":"19","author":"Kumar","year":"2013","journal-title":"Indian J Hum Genet"},{"key":"10.4103\/2156-7514.139738\/ref-5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-199309000-00005","article-title":"Osteopetrosis. Current clinical considerations","author":"Shapiro","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"10.4103\/2156-7514.139738\/ref-6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1542\/peds.93.2.247","article-title":"Autosomal recessive osteopetrosis: Variability of finding sat diagnosis and during the natural course","volume":"93","author":"Gerritsen","year":"1994","journal-title":"Pediatrics"},{"key":"10.4103\/2156-7514.139738\/ref-7","first-page":"39","article-title":"Malignant infantile osteopetrosis: Dental effects in paediatric patients. Case reports","volume":"7","author":"Luzzi","year":"2006","journal-title":"Eur J Paediatr Dent"},{"key":"10.4103\/2156-7514.139738\/ref-8","first-page":"2432","article-title":"Disorders Involving Defective Bone Resorption","volume-title":"Nelson Textbook of Pediatrics","author":"Kliegman","year":"2011","edition":"19th ed"},{"key":"10.4103\/2156-7514.139738\/ref-9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1172-4-5","article-title":"Osteopetrosis","volume":"4","author":"Stark","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"10.4103\/2156-7514.139738\/ref-10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/01.mph.0000179961.72889.bf","article-title":"Successful nonmyeloablative cord blood transplantation for an infant with malignant infantile osteopetrosis","volume":"27","author":"Tsuji","year":"2005","journal-title":"J Pediatr Hematol Oncol"}],"container-title":["Journal of Clinical Imaging Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/clinicalimagingscience.org\/an-infant-with-splenohepatomegaly-a-rare-cause\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/clinicalimagingscience.org\/an-infant-with-splenohepatomegaly-a-rare-cause\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T20:00:35Z","timestamp":1650052835000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalimagingscience.org\/an-infant-with-splenohepatomegaly-a-rare-cause\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,30]]},"references-count":10,"alternative-id":["10.4103\/2156-7514.139738"],"URL":"https:\/\/doi.org\/10.4103\/2156-7514.139738","relation":{},"ISSN":["2156-7514"],"issn-type":[{"value":"2156-7514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,30]]},"article-number":"48"}}