{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:15:58Z","timestamp":1768281358102,"version":"3.49.0"},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nObjectives:<\/jats:title>\nTo determine the dimensions of normal pituitary gland using T1-weighted magnetic resonance images (MRI) and to determine their relationship with age and sex.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods:<\/jats:title>\nCranial MRI scans of 100 individuals with clinically normal pituitary function (58 males and 42 females) and in the age range 14\u201382 years were reviewed in order to obtain volumetric measurements of the pituitary gland. The height, width, and depth of the pituitary were obtained from mid-sagittal and coronal planes, while the volume was calculated from these measured parameters. The data obtained were stratified based on age and sex for analysis. Statistical tests applied included Student's t<\/jats:italic>-test and Pearson correlation. A minimum level of statistical significance was set at P<\/jats:italic> < 0.05.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nThe mean pituitary volumes were 334.1 \u00b1 145.8 mm3<\/jats:sup> and 328.1 \u00b1 129.2 mm3<\/jats:sup> while the mean pituitary heights were 6.45 \u00b1 1.7 mm and 6.46 \u00b1 1.57 mm in males and females, respectively. Although there was no statistically significant difference between pituitary height and pituitary volume in both sexes, they correlated negatively with increasing age (r<\/jats:italic> = \u2212202, P<\/jats:italic> = 0.04 and r<\/jats:italic> = \u2212410, P<\/jats:italic> = 0.000, respectively). Both parameters were highest in pubertal subjects and declined steadily with age, with a second peak occurring only for pituitary height in the sixth decade. The mean pituitary widths (9.08 \u00b1 2.59 mm and 9.21 \u00b1 1.86 mm) and depths (10.59 \u00b1 1.71 mm and 10.49 \u00b1 1.57 mm) in males and females, respectively, did not show remarkable changes with age and sex in the individuals studied.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nWith this study, we have provided reference values in Nigerian population for the dimensions of normal pituitary gland, in order to facilitate assessment and diagnosis in patients with abnormalities of the hypothalamic\u2013pituitary axis.<\/jats:p>\n<\/jats:sec>","DOI":"10.4103\/2156-7514.157853","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T07:15:25Z","timestamp":1432883725000},"page":"29","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Magnetic Resonance Imaging Determination of Normal Pituitary Gland Dimensions in Zaria, Northwest Nigerian Population"],"prefix":"10.25259","volume":"5","author":[{"given":"Philip Oluleke","family":"Ibinaiye","sequence":"first","affiliation":[{"name":"Department of Radiology and Endocrine Unit, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefia","family":"Olarinoye-Akorede","sequence":"additional","affiliation":[{"name":"Department of Radiology and Endocrine Unit, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olugbenga","family":"Kajogbola","sequence":"additional","affiliation":[{"name":"Department of Radiology and Endocrine Unit, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adamu Girei","family":"Bakari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"10.4103\/2156-7514.157853\/ref-1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11102-006-7503-5","article-title":"Weight and dimensions of the pituitary in Northwestern Indians","volume":"9","author":"Sahni","year":"2006","journal-title":"Pituitary"},{"key":"10.4103\/2156-7514.157853\/ref-2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00342982","article-title":"A parallel study of the roentgen anatomy of the sella turcica and histopathology of the pituitary gland in 205 autopsy specimens","volume":"21","author":"Muhr","year":"1981","journal-title":"Neuroradiology"},{"key":"10.4103\/2156-7514.157853\/ref-3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2265.1996.tb02055.x","article-title":"Role of magnetic resonance imaging in the diagnosis and prognosis of growth hormone deficiency","volume":"45","author":"Bozzola","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4103\/2156-7514.157853\/ref-4","first-page":"406","article-title":"Comparative morphological study of the pituitary gland by computed tomography and magnetic resonance imaging","volume":"74","author":"Loxton","year":"1988","journal-title":"S Afr Med J"},{"key":"10.4103\/2156-7514.157853\/ref-5","first-page":"9","article-title":"Imaging of the pituitary gland","volume":"18","author":"Forbes","year":"2002","journal-title":"Barrow quarterly"},{"key":"10.4103\/2156-7514.157853\/ref-6","doi-asserted-by":"crossref","first-page":"696","DOI":"10.4103\/0028-3886.86543","article-title":"3D volumetry comparison using 3T magnetic resonance imaging between normal and adenoma-containing pituitary glands","volume":"59","author":"Roldan-Valadez","year":"2011","journal-title":"Neurol India"},{"key":"10.4103\/2156-7514.157853\/ref-7","first-page":"3990","article-title":"Growth Hormone Research Society. 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