{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:06:44Z","timestamp":1792152404136,"version":"4.4.0"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>The EEC syndrome is a genetic anomaly characterized by the triad: ectodermal dysplasia (development of anomalies of the structures derived from the embryonic ectodermal layer), ectrodactyly (extremities, hands and feet malformations) and cleft lip and\/or palate; these malformations can be seen together or in isolation. The prenatal diagnosis can be made by two-dimensional ultrasonography (2DUS) that identifies the facial and\/or limb anomalies, most characteristic being the \u201clobster-claw\u201d hands. The three-dimensional ultrasonography (3DUS) provides a better analysis of the malformations than the 2DUS. A 25-year-old primigravida, had her first transvaginal ultrasonography that showed an unique fetus with crow-rump length of 47 mm with poorly defined hands and feet,. She was suspected of having sporadic form of EEC syndrome. The 2DUS performed at 19 weeks confirmed the EEC syndrome, showing a fetus with lobster-claw hands (absence of the 2<jats:sup>nd<\/jats:sup> and 3<jats:sup>rd<\/jats:sup> fingers), left foot with the absence of the 3rd toe and the right foot with syndactyly, and presence of cleft lip\/palate. The 3DUS defined the anomalies much better than 2DUS including the lobster-claw hands.<\/jats:p>","DOI":"10.4103\/2156-7514.99153","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T13:38:44Z","timestamp":1343482724000},"page":"40","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal Diagnosis of EEC Syndrome with \u201cLobster Claw\u201d Anomaly by 3D Ultrasound"],"prefix":"10.25259","volume":"2","author":[{"given":"Livia T.","family":"Rios","sequence":"first","affiliation":[{"name":"Mother-Child Unit, Universitary Hospital, Federal University of Maranh\u00e3o (UFMA), S\u00e3o Luiz, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"J\u00fanior","given":"Edward","family":"Araujo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C. R.","family":"Caetano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano M.","family":"Nardozza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio F.","family":"Moron","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia G.","family":"Martins","sequence":"additional","affiliation":[{"name":"Mother-Child Unit, Universitary Hospital, Federal University of Maranh\u00e3o (UFMA), S\u00e3o Luiz, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2012,7,28]]},"reference":[{"key":"10.4103\/2156-7514.99153\/ref-1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1001\/archpedi.1970.02100070104016","article-title":"Association of ectrodactyly, ectodermal dysplasia, and cleft lip-palate","volume":"120","author":"R\u00fcdiger","year":"1970","journal-title":"Am J Dis Child"},{"key":"10.4103\/2156-7514.99153\/ref-2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ajmg.1320370112","article-title":"EEC syndrome: Report on 20 new patients, clinical and genetic considerations","volume":"37","author":"Rodini","year":"1990","journal-title":"Am J Med Genet"},{"key":"10.4103\/2156-7514.99153\/ref-3","first-page":"433","article-title":"Prune belly anomaly on prenatal ultrasound as a presenting feature of ectrodactyly-ectodermal dysplasia-clefting syndrome 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