{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:19:50Z","timestamp":1787761190995,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>We report a case of successful management of intravitreal injections of anti-vascular endothelial growth factor antibody bevacizumab in two unusual complications, preretinal neovascularization and vitreous hemorrhage, secondary to a combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). A male pediatric patient suffered from decreased vision in the right eye at 5-year-old. His ophthalmologic examination revealed a CHRRPE involving the superior area of the optic disc and macula in the right eye. The patient\u2019s family history and neurological examinations of tuberous sclerosis were absent. While no lesion growth was observed over time, preretinal vascularization and recurrent nonclearing hemorrhage occurred 2 years after the initial presentation. The patient was successfully managed with two intravitreal injections of bevacizumab. No recurrences of vitreous hemorrhage were observed at a 7-year post-treatment follow-up. Intravitreal injections of bevacizumab were safe and effective in the management of uncommon complications of preretinal neovascularization and vitreous hemorrhage of CHRRPE in a pediatric patient in long-term follow-up.<\/jats:p>","DOI":"10.4103\/2211-5056.364566","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:36:56Z","timestamp":1671583016000},"page":"556-559","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Seven-year follow-up of a pediatric patient with combined hamartoma of retina and retinal pigment epithelium complicating with preretinal neovascularization and vitreous hemorrhage treated with intravitreal injections of bevacizumab"],"prefix":"10.4103","volume":"13","author":[{"given":"Tsung-Ying","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan"},{"name":"Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Ning","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan"},{"name":"Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"R1-20240830","first-page":"171","article-title":"An unusual hamartoma of the pigment epithelium and retina simulating choroidal melanoma and retinoblastoma","volume":"71","author":"Gass","year":"1973","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ophtha.2012.07.067","article-title":"Lesions simulating retinoblastoma (pseudoretinoblastoma) in 604 cases: Results based on age at presentation","volume":"120","author":"Shields","year":"2013","journal-title":"Ophthalmology"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3928\/1542-8877-20000301-13","article-title":"Combined hamartoma of the retina and retinal pigment epithelium as the presenting sign of neurofibromatosis-1","volume":"31","author":"Tsai","year":"2000","journal-title":"Ophthalmic Surg Lasers"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archopht.1991.01080050076033","article-title":"Retinal manifestations of neurofibromatosis. 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