{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:01Z","timestamp":1787840281924,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n Objective\/Background:<\/jats:title>\n Introduction of the interferon gamma (IFN-\u03b3) release assays with their higher sensitivity and specificity over the traditional tuberculin skin test has improved testing for latent tuberculosis infection (LTBI). None of the IFN-\u03b3 release assays has ever been used to screen for LTBI in Ghana. This study set out to determine the utility of the QuantiFERON TB Gold-in-Tube (QFT-GIT) test for the diagnosis of LTBI among close household contacts of newly diagnosed sputum smear-positive tuberculosis (TB) patents in Accra, Ghana, and the associated risk factors for a positive QFT-GIT test.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Close household contacts of newly diagnosed sputum smear-positive patients receiving anti-TB therapy from three hospitals in Accra were recruited, after providing written informed consent, between April 2012 and December 2014. In addition to demographic details, 2 mL of blood was collected from all participants for the QFT-GIT test for LTBI diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Out of 112 eligible consenting participants, the QFT-GIT test was performed for 100 participants. The prevalence of LTBI (QFT-GIT positive) was 65%, with 32% being QFT-GIT negative and 3% indeterminate results. Contacts aged >15 years were more likely to be QFT-GIT positive than those aged >15 years, regardless of their\n Bacillus<\/jats:italic>\n Calmette\u2013Guerin status. There was significantly higher QFT-GIT test positivity in adult contacts who were parents, siblings, or spouses to index cases than in child contacts (\n P<\/jats:italic>\n = 0.0016,\n P<\/jats:italic>\n = 0.04, and\n P<\/jats:italic>\n = 0.0003, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The QFT-GIT test will be a useful tool for screening of TB contacts for LTBI in Ghana.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/2212-5531.201891","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T11:07:10Z","timestamp":1495105630000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Utility of QuantiFERON Tuberculosis Gold-in-Tube Test for Detecting Latent Tuberculosis Infection among Close Household Contacts of Confirmed Tuberculosis Patients in Accra, Ghana"],"prefix":"10.4103","volume":"6","author":[{"given":"Gloria Ivy","family":"Mensah","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Akoley","family":"Sowah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana Yaw Asare","family":"Yeboah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennedy Kwasi","family":"Addo","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Jackson-Sillah","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250603","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/archinte.163.9.1009","article-title":"The growing burden of tuberculosis: Global trends and interactions with the HIV epidemic","volume":"163","author":"Corbett","year":"2003","journal-title":"Arch Intern Med"},{"key":"R3-20250603","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJM198903023200901","article-title":"A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection","volume":"320","author":"Selwyn","year":"1989","journal-title":"N Engl J Med"},{"key":"R4-20250603","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1183\/09031936.00120908","article-title":"LTBI: Latent tuberculosis infection or lasting immune responses to M. tuberculosis? 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