{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:42Z","timestamp":1791839922658,"version":"4.3.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The contact allergic reactions from\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -phenylenediamine (PPD) in hair dyes vary from mild contact dermatitis to severe life- threatening events (angioedema, bronchospasm, asthma, renal impairment).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Eighty (M:F 47:33) consecutive patients aged between 18 and 74 years suspected to have contact allergy from hair dye were studied by patch testing with Indian Standard Series including\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -phenylenediamine (PPD, 1.0% pet).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>54 Fifty-four (M:F 21:33) patients showed positive patch tests from PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix, paraben mix, or colophony. Fifty-seven (71%) patients affected were aged older than 40 years. The duration of dermatitis varied from &lt; 1 month to &gt; 1 year with exacerbation following hair coloring. Forty-nine patients had dermatitis of scalp and\/or scalp margins and 23 patients had face and neck dermatitis. Periorbital dermatitis, chronic actinic dermatitis, and erythema multiforme-like lesions were seen in 4, 2, and 1 patients, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Hair dyes and PPD constitute a significant cause of contact dermatitis. There is an urgent need for creating consumer awareness regarding hair-dyes contact sensitivity and the significance of performing sensitivity testing prior to actual use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2229-5178.160253","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T05:22:37Z","timestamp":1436332957000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Hair dye dermatitis and p-phenylenediamine contact sensitivity: A preliminary report"],"prefix":"10.4103","volume":"6","author":[{"given":"Mrinal","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram K.","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karaninder S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpinder S.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Dr. Rajendra Prasad, Government Medical College, Tanda, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2133.2005.06588.x","article-title":"Contact dermatitis to hair dyes in an adult Danish population-: An interview-based study","volume":"153","author":"S\u00f8sted","year":"2005","journal-title":"Br J Dermatol"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4103\/0974-7753.125610","article-title":"Trends in use of hair dye: A cross-sectional study","volume":"5","author":"Patel","year":"2013","journal-title":"I Int J Trichologynt J Trichol"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.0105-1873.2004.00440.x","article-title":"Ranking of hair dye substances according to predicted sensitization potency-quantitative structure-activity relationships","volume":"51","author":"Sosted","year":"2004","journal-title":"Contact Dermatitis"},{"key":"R4-20260327","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1034\/j.1600-0536.2000.042005270.x","article-title":"Experimental study on skin sensitization potencies and cross-reactivities of hair-dye-related chemicals in guinea pigs","volume":"42","author":"Xie","year":"2000","journal-title":"Contact Dermatitis"},{"key":"R5-20260327","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-0536.2003.480207.x","article-title":"Is PPD a useful screening agent?","volume":"48","author":"Koopmans","year":"2003","journal-title":"Contact Dermatitis"},{"key":"R6-20260327","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0536.2008.01427.x","article-title":"European Society of Contact Dermatitis. 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