{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:27Z","timestamp":1786653687542,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Elevation of C-reactive protein (CRP) has been reported to occur in psoriasis, urticaria, acne, rosacea and many other dermatological and nondermatological conditions. Chronic systemic inflammation has been implicated in the development of neuropsychiatric\/degenerative disorders, atherosclerosis, coronary artery disease, diabetes mellitus and even carcinogenesis. The present study is designed to determine whether the level of inflammation created by acne vulgaris could be high enough to raise the serum levels of high-sensitive CRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Forty-two patients with moderate and severe acne vulgaris were enrolled, along with 44 age and sex matched healthy blood donors as controls. Hypersensitive-CRP (Hs-CRP) was measured in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Hypersensitive-C-reactive protein levels in the case group varied between 0 and 28.1 \u03bcg\/ml with an average of 2.24 \u00b1 4.87 \u03bcg\/ml (mean \u00b1 standard deviation) and a median of 0.6 \u03bcg\/ml (interquartile range [IQR] =0.3, 1.4 \u03bcg\/ml). Hs-CRP levels of the control group varied between 0 and 14 \u03bcg\/ml with an average of 3.12 \u00b1 3.67 \u03bcg\/ml and a median of 1.5 \u03bcg\/ml (IQR = 0.55, 5.0 \u03bcg\/ml). No significant difference of Hs-CRP level between the two groups was seen (\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      = \u20130.961, 95% confidence interval: Lower = \u20132.6942, upper = 0.9377;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.339). Additionally, no significant difference in the level of Hs-CRP was noted between the moderate and severe acne groups (95% confidence interval: Lower = \u20135.2495, upper = 1.6711;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.165).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acne vulgaris, even in its severe grades (excluding acne fulminans and acne conglobata), does not induce significant inflammation at the systemic level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2229-5178.160256","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T05:22:37Z","timestamp":1436332957000},"page":"253-257","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Serum levels of hypersensitive-C-reactive protein in moderate and severe acne"],"prefix":"10.4103","volume":"6","author":[{"given":"M. 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