{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:58Z","timestamp":1787071438974,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Mantle cell lymphoma (MCL) is a form of non-Hodgkin lymphoma that rarely affects skin. Cutaneous involvement is non-specific but usually indicates widespread disease. Herein we present two cases of MCL with secondary skin involvement. One case presented as an acneiform eruption on the face and had aberrant expression of bcl-2 and bcl-6 with weak CD5 expression. The second presented with multiple tumors on the abdomen and thighs. In both cases expression of Cyclin-D1 by the tumor cells was seen. Both patients died shortly after the diagnosis was established.<\/jats:p>","DOI":"10.4103\/2229-5178.174317","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T06:33:53Z","timestamp":1453962833000},"page":"49-52","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Two cases of systemic mantle cell lymphoma involving the skin"],"prefix":"10.4103","volume":"7","author":[{"given":"Viktoryia","family":"Kazlouskaya","sequence":"first","affiliation":[{"name":"Ackerman Academy of Dermatopathology, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Spizuoco","sequence":"additional","affiliation":[{"name":"Ackerman Academy of Dermatopathology, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Junkins-Hopkins","sequence":"additional","affiliation":[{"name":"Ackerman Academy of Dermatopathology, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MOH.0b013e328302c9c5","article-title":"Mantle cell lymphoma: Advances in biology and therapy","volume":"15","author":"Smith","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2340\/00015555-0886","article-title":"Cutaneous presentation of mantle cell lymphoma","volume":"90","author":"Canpolat","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/00000478-200210000-00008","article-title":"Mantle cell lymphoma involving skin: Cutaneous lesions may be the first manifestation of disease and tumors often have blastoid cytologic features","volume":"26","author":"Sen","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"R4-20260327","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/jamadermatol.2013.5388","article-title":"Disseminated mantle-cell lymphoma presenting as a petechial maculopapular eruption","volume":"150","author":"Jawed","year":"2014","journal-title":"JAMA Dermatol"},{"key":"R5-20260327","first-page":"394596","article-title":"Primary cutaneous mantle cell lymphoma: A case report","author":"Mazzuoccolo","year":"2013","journal-title":"Case Rep Dermatol Med 2013"},{"key":"R6-20260327","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-0560.2011.01832.x","article-title":"Primary cutaneous mantle cell lymphoma with blastic features: Report of a rare case with special reference to staging and effectiveness of chemotherapy","volume":"39","author":"Lynch","year":"2012","journal-title":"J Cutan Pathol"},{"key":"R7-20260327","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2340\/00015555-1084","article-title":"Primary cutaneous mantle cell lymphoma","volume":"91","author":"Zattra","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"R8-20260327","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/DAD.0b013e31819d845a","article-title":"Primary cutaneous blastoid mantle cell lymphoma-case report","volume":"31","author":"Estrozi","year":"2009","journal-title":"Am J Dermatopathol"},{"key":"R9-20260327","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0190-9622(94)70002-8","article-title":"Mantle zone lymphoma: An immunohistologic study of skin lesions","volume":"30","author":"Bertero","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"R10-20260327","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1097\/DAD.0b013e31828bc7ac","article-title":"Primary cutaneous mantle cell lymphoma of the leg with blastoid morphology and aberrant immunophenotype: A diagnostic challenge","volume":"36","author":"Cesinaro","year":"2014","journal-title":"Am J Dermatopathol"},{"key":"R11-20260327","first-page":"2253","article-title":"Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: A clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma","volume":"95","author":"Yatabe","year":"2000","journal-title":"Blood"},{"key":"R12-20260327","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1309\/AJCP27YWLIQRAJPW","article-title":"CD23 expression in follicular lymphoma: Clinicopathologic correlations","volume":"135","author":"Olteanu","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"R13-20260327","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1182\/blood-2005-04-1753","article-title":"Lymphoma\/Leukemia Molecular Profiling Project. Cyclin D1-negative mantle cell lymphoma: A clinicopathologic study based on gene expression profiling","volume":"106","author":"Fu","year":"2005","journal-title":"Blood"},{"key":"R14-20260327","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1309\/508R-YBWW-Y0AC-82GA","article-title":"Value of interphase FISH for the diagnosis of t(11:14)(q13;q32) on skin lesions of mantle cell lymphoma","volume":"118","author":"Dubus","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"R15-20260327","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2559.2005.02323.x","article-title":"Blastoid and common variants of mantle cell lymphoma exhibit distinct immunophenotypic and interphase FISH features","volume":"48","author":"Parrens","year":"2006","journal-title":"Histopathology"},{"key":"R16-20260327","first-page":"879","article-title":"Mantle cell lymphoma: Clinicopathologic features and treatments","volume":"17","author":"Kauh","year":"2003","journal-title":"Oncology (Williston Park)"},{"key":"R17-20260327","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1046\/j.1365-2141.1996.5421085.x","article-title":"Large-cell variants of mantle cell lymphoma: Cytologic characteristics and p53 anomalies may predict poor outcome","volume":"93","author":"Zoldan","year":"1996","journal-title":"Br J Haematol"},{"key":"R18-20260327","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/DAD.0b013e3181b2ed67","article-title":"Mantle cell lymphoma with skin invasion characterized by the common variant in the subcutis and blastoid transformation in the overlying dermis","volume":"32","author":"Ishibashi","year":"2010","journal-title":"Am J Dermatopathol"},{"key":"R19-20260327","first-page":"11","article-title":"Pitfalls in diagnostic hematopathology: Part I","volume":"2","author":"Zhao","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"R20-20260327","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/cup.12109","article-title":"CD10-positive blastoid mantle cell lymphoma with secondary cutaneous involvement","volume":"40","author":"Phelps","year":"2013","journal-title":"J Cutan Pathol"},{"key":"R21-20260327","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2559.2008.03060.x","article-title":"Mantle cell lymphoma with aberrant expression of CD10","volume":"53","author":"Zanetto","year":"2008","journal-title":"Histopathology"},{"key":"R22-20260327","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1182\/blood.V94.2.765","article-title":"Anomalous high p27\/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression-p27\/KIP1-cyclin D3 colocalization in tumor cells","volume":"94","author":"S\u00e1nchez-Beato","year":"1999","journal-title":"Blood"},{"key":"R23-20260327","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1309\/42CQ0HU7XEY9QMQX","article-title":"A subset of CD5- diffuse large B-cell lymphomas expresses nuclear cyclin D1 with aberrations at the CCND1 locus","volume":"129","author":"Ehinger","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"R24-20260327","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1001\/archderm.143.9.1144","article-title":"Primary cutaneous diffuse large B-cell lymphoma, leg type: Clinicopathologic features and prognostic analysis in 60 cases","volume":"143","author":"Grange","year":"2007","journal-title":"Arch Dermatol"},{"key":"R25-20260327","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/PAS.0b013e3181e5060a","article-title":"IgM expression on paraffin sections distinguishes primary cutaneous large B-cell lymphoma, leg type from primary cutaneous follicle center lymphoma","volume":"34","author":"Koens","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R26-20260327","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1365-2559.2012.04260.x","article-title":"SOX11 is useful in differentiating cyclin D1-positive diffuse large B-cell lymphoma from mantle cell lymphoma","volume":"61","author":"Hsiao","year":"2012","journal-title":"Histopathology"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01630814-201607010-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:11Z","timestamp":1787067971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01630814-201607010-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/2229-5178.174317","relation":{},"ISSN":["2229-5178","2249-5673"],"issn-type":[{"value":"2229-5178","type":"print"},{"value":"2249-5673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}