{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:02Z","timestamp":1787071442159,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Ulcerative necrobiosis lipoidica (NL) in diabetic patients is a rare, painful condition. It is a difficult-to-treat condition, impairing quality of life of patients. Although various drugs have been tried, none of them is consistently effective. Biologics in the form of TNF-alpha inhibitors show promising results in the treatment. But because of their high cost we chose thalidomide, which also has TNF-alpha inhibiting properties to successfully treat a long-standing case of ulcerative NL, which was refractory to various treatment modalities.<\/jats:p>","DOI":"10.4103\/2229-5178.174328","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T06:33:53Z","timestamp":1453962833000},"page":"43-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide"],"prefix":"10.4103","volume":"7","author":[{"given":"Swapnil D.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Ashvini Rural Medical College, Solapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish V.","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Ashvini Rural Medical College, Solapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.clindermatol.2006.04.009","article-title":"Diabetes mellitus","volume":"24","author":"Ahmed","year":"2006","journal-title":"Clin Dermatol"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2230.1988.tb01966.x","article-title":"Aggressive ulcerative necrobiosis lipoidica associated with venous insufficiency, giant-cell phlebitis and arteritis","volume":"13","author":"Markey","year":"1988","journal-title":"Clin Exp Dermatol"},{"key":"R3-20260327","first-page":"581","article-title":"Cutaneous microcirculation in pretibial necrobiosis lipoidica. Comparative laser Doppler flowmetry and oxygen partial pressure determinations in patients and healthy probands","volume":"44","author":"Boateng","year":"1993","journal-title":"Hautarzt"},{"key":"R4-20260327","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/14746514050050010701","article-title":"The treatment of necrobiosis lipoidica","volume":"5","author":"Tidman","year":"2005","journal-title":"Br J Diabetes Vasc Dis"},{"key":"R5-20260327","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1034\/j.1600-0560.2001.028006287.x","article-title":"Expression of the human erythrocyte glucose transporter Glut-1 in areas of sclerotic collagen in necrobiosis lipoidica","volume":"28","author":"Holland","year":"2001","journal-title":"J Cutan Pathol"},{"key":"R6-20260327","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/120347540500900605","article-title":"Off-label dermatologic uses of anti-TNF-a therapies","volume":"9","author":"Alexis","year":"2005","journal-title":"J Cutan Med Surg"},{"key":"R7-20260327","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archderm.142.1.20","article-title":"Thalidomide for the treatment of refractory necrobiosis lipoidica","volume":"142","author":"Kukreja","year":"2006","journal-title":"Arch Dermatol"},{"key":"R8-20260327","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1517\/14740338.3.1.47","article-title":"Thalidomide: An old drug with new clinical applications","volume":"3","author":"Laffitte","year":"2004","journal-title":"Expert Opin Drug Saf"},{"key":"R9-20260327","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000314694","article-title":"Necrobiosis lipoidica therapy with biologicals: An ulcerated case responding to etanercept and a review of the literature","volume":"221","author":"Su\u00e1rez-Amor","year":"2010","journal-title":"Dermatology"},{"key":"R10-20260327","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1046\/j.1523-1747.2003.12565.x","article-title":"Thalidomide inhibits tumor necrosis factor-alpha production and antigen presentation by Langerhans cells","volume":"121","author":"Deng","year":"2003","journal-title":"J Invest Dermatol"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01630814-201607010-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:12Z","timestamp":1787067972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01630814-201607010-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/2229-5178.174328","relation":{},"ISSN":["2229-5178","2249-5673"],"issn-type":[{"value":"2229-5178","type":"print"},{"value":"2249-5673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}